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December 20, 2004
CHEMISTRY HIGHLIGHTS
2004
Key advances were made this year in areas ranging from biochemistry, drug research,
and analysis to nanotech and inorganic chemistry.
2004 INDUSTRY
REVIEW
The upturn is no longer elusive, and although challenges remain, prosperity is
finally returning to the chemical industry.
December 13, 2004
ACS Takes
Legal Action Against Google
Google search service is said to infringe SciFinder
Scholar
National Chemistry
Week
This year's activities centered around the theme of "Health and Wellness."
December 6, 2004
PHARMA
REVIEW
Competition from generics, pricing pressures, cost containment, and regulatory
issues are among the problems the pharmaceutical industry is facing.
CONTRACT RESEARCH ORGANIZATIONS
CROs provide essential services and adapt to fit changing needs of pharmaceutical firms.
November 29, 2004
HUBBLE TELESCOPE
After 15
years, the aging instrument needs a serious tune-up, but the shuttle fleet that would do it is
grounded.
DISPUTED
HISTORY
Elias J. Corey's claim to have originated the idea behind the Woodward-Hoffmann
rules is unfair, Roald Hoffmann says.
November 22, 2004
METABOLIC
SYNDROME
Complex set of disorders offers drug development opportunities; a new NMR
technique measures low-density lipoproteins.
November 15, 2004
ACADEMIC
R&D
Latest NSF data from 2002 show marked growth in funding for chemical
research.
November 8, 2004
RENEWABLE
RESOURCES
Increases in the price of oil may drive specialty chemicals into a
postpetroleum era.
November 1, 2004
EMPLOYMENT
OUTLOOK
Amid record-high unemployment for chemists, C&EN offers advice on a new job
hunt, midcareer transitions, and temporary jobs, as well as a salary review and information on job
resources.
October 25, 2004
DIABETES
DRUGS
Treatment paradigm involving peptide hormone receptor promises new hope for
therapy.
October 18, 2004
PAINTS &
COATINGS
Markets shift, regulations tighten, and the industry looks toward new
technologies.
CHLORINE
C. T. Howlett
Jr. and Terrence Collins debate chlorine's positive and negative contributions.
DREAM JOBS
C&EN examines
what makes some companies leaders in employee relations.
October 11, 2004
PROCESS
CHEMICALS
Specialty chemical strategies for the 21st century are clearly emerging in the
concrete, dyes, paper, and leather
industries.
October 4, 2004
OCEAN
ENERGY
Entrepreneurs hope to market clean, affordable electricity from the power of
tides, waves, or any water in motion.
COMBICHEM
Modeled after natural
products, diversity-oriented synthesis gives hope to a field in need of a boost.
MEDICAL DEVICES
Chemical
engineers, like chemists, are in demand in this industry, which is thriving in New England.
September 27, 2004
HIGH-PERFORMANCE
COMPUTING
Demand for computers of all sizes and designs is continually increasing for all
kinds of problems in chemistry.
ACADEMIC SCORECARD
Women
continue to be underrepresented in the faculty of top 50 chemistry departments.
September 20, 2004
STRUCTURAL
PROTEOMICS
Biotechnology companies try to meet demand for contract research in this
dynamic market.
POSTDOCTORAL EXPERIENCE
Four-part supplement discusses the challenges and opportunities facing today's postdocs, as well
as a new education standardization in Europe.
September 13, 2004
NUCLEAR
ENERGY
Next generations of reactors will have evolutionary and revolutionary designs.
September 6, 2004
FINE
CHEMICALS
Suzuki coupling and related chemistries gain ground in commercial practice,
from small-scale synthesis to industrial-scale production.
August 30, 2004
ADVANCED COMPOSITES
By
blending distinct components, researchers make materials for auto, aerospace, defense, and other
industries.
August 23, 2004
AGING
Scientists attempt to
understand the triggers, timing, and molecular basis of this inevitable condition.
August 16, 2004
EMPLOYMENT &
SALARY SURVEY
The job market for chemists continues to be difficult, but salaries have
improved.
August 9, 2004
CARBOHYDRATE
VACCINES
Novel techniques for constructing and synthesizing antigenic carbohydrates are
making possible a new generation of vaccines.
August 2, 2004
DAVID KAY
Former
head of CIA's weapons investigation group in Iraq discusses the lessons learned from the search for
weapons of mass destruction.
July 26, 2004
DRUG
DISCOVERY
Realism replaces hype as research scientists put high-throughput screening
methods in their place.
July 19, 2004
GLOBAL TOP
50
Worldwide sales show a striking increase, but profits continue to slip.
CHEMRAWN XV
Conference in Paris spotlights chemistry???s global role in attaining safe and
reliable water supplies.
COURTING
CHEMISTS
Chemists' expertise is sought by medical device industry.
July 12,
2004
GREEN
CHEMISTRY HONORS
Presidential honors recognize innovative chemical products and processes
that prevent pollution.
July 5, 2004
FACTS
& FIGURES
Chemical industry data for 2003 do not look very different from those of
2002--yet cost-cutting reorganizations of the previous few years are affecting the bottom line.
June 28, 2004
ELECTRONIC
CHEMICALS
Sparked by higher demand, such as flat-screen TVs, the semiconductor materials
business is booming once again as environmental concerns increase.
June 21, 2004
SOLAR ENERGY
With
scientific breakthroughs on the horizon and production costs dropping, advocates say solar energy is
on the cusp of a huge expansion.
WHAT'S THAT
STUFF?
No-calorie sugar substitutes have sweetening powers hundreds of times that of
sucrose.
June 14, 2004
CHIRAL
CHEMISTRY
Traditional methods thrive because numerous hurdles, including tough luck, slow
down the commercialization of catalytic processes.
WORLDWIDE SCIENCE
Growth
in scientific papers is mostly in Europe and Asia.
June 7, 2004
BHOPAL
Twenty years later,
Responsible Care has changed industry's approach to safety; third-party audits could help regain the
public's trust.
CHEMISTS OF THE
CARIBBEAN
Chemistry in the West Indies flourishes despite infrastructure and funding
issues.
FLAVORS &
FRAGRANCES
Chemists' work combines biology, chemistry, and psychology to create tempting
products.
May 31, 2004
CONTROLLING MAD COW
DISEASE
Malady presents a difficult regulatory challenge, in part because of gaps in the
science of prion diseases.
THREE
RINGS
Mix-and-heat strategy yields Borromean rings.
May 24, 2004
ANTIVIRAL
DRUGS
Despite biological and economic challenges, a number of strategies are in the
pipeline to fight viral respiratory infections.
MASS SPEC ASSAY
Strategy for
rapid screening of chemical libraries yields inhibitor of anthrax toxin.
May 17, 2004
TOP 50 U.S. CHEMICAL
PRODUCERS
C&EN's annual survey finds economic recovery lifting sales and profits, but
a lack of deal making leaves the ranking little changed.
Killing Fat
Antiangiogenesis
strategy targets fat cells and returns overfed mice to normal weight.
May 10, 2004
PROTEIN
DRUGS
Rapid transformation in business and research has turned large drug firms into
biotech players, while contract service firms move into life-cycle management.
May 3,
2004
PERSONAL
CARE
Cosmetic makers seek new ingredients and formulations to mitigate effects of aging;
FDA scrutinizes claims of therapeutic benefits.
COMBINATORIAL
CHEMISTRY
Techniques are incorporated into the routine work of drug discovery.
April 26, 2004
CARBOHYDRATE
CALCULATIONS
Despite their complexity, carbohydrates are finally yielding to the power of
computational chemistry.
ETHICS
EDUCATION
Colleges make an effort to fit research ethics into the curriculum.
WHAT'S THAT STUFF?
Kitty
litter choices range from simple clays to silica gels to plant-derived alternatives.
April 19, 2004
SPECIALTY CHEMICALS
Key
players explain how they have adapted to succeed in changing markets.
2003 STARTING SALARY SURVEY
Job market is still soft, median salaries have dropped, and number of unemployed
has held steady.
April 12, 2004
NANOTECH IP
Broad
potential of this "next big thing" has early developers looking to protect their intellectual
property.
NANOTECHNOLOGY
Four
Scientists offer advice on how to be a megastar employee in a nanoworld.
SCIENTIFIC PUBLISHING
Treasury office
concedes that regulations on sanctioned countries do not involve U.S. publishing.
April 5, 2004
PHARMA OUTSOURCING
Four case studies of outsourcing relationships show that good service is rewarded with repeat
business.
NANOKIDS
Project uses
"character" molecules to draw students into science.
WHAT'S THAT STUFF?
Special
adhesive developed by 3M has led to ubiquitous and indispensable sticky notes.
March 29, 2004
2004
PRIESTLEY MEDALIST
Nobel Prize winner E. J. Corey is honored for his profound
contributions to organic chemistry and biomedical sciences.
DOWN THE YANGTZE
C&EN's
Asia-Pacific correspondent reports on today's China as he continues down the Yangtze River.
AHA! MOMENTS: ROBERT R.
BREAKER
Why doesn't nature use RNA molecules to sense specific metabolites and thus
regulate gene expression? Nature does, Breaker thought, but no one realized it.
March 22, 2004
DATA MANAGEMENT
Amid
a deluge of collected facts and figures, the chemical and pharmaceutical industries seek new
information technology solutions.
CRITTER CHEMISTRY
A powerful
neurotoxin from puffer fish provides pain relief for some cancer patients.
BIRTH OF A
DRUG
Chemists in a variety of subdisciplines team with other scientists in the making of
a new drug.
DOWN THE
YANGTZE
Join C&EN's Asia-Pacific correspondent on his monthlong river journey to
experience today's China.
March 15, 2004
PETROCHEMICALS
North American producers adjust to a changed industry, European producers consolidate, and Japanese
producers receive a respite.
March 8, 2004
NITRIC OXIDE'S NEW
PLAYER?
Researchers explore the chemistry of NO's biological alter ego, HNO.
March 1, 2004
DRUG
DELIVERY
Companies emphasize products over platforms and are positioning their
technologies earlier in the drug development timeline.
FORENSIC SCIENCE
It
may not be as dramatic as popular TV shows portray, but painstaking chemical analysis is still an
exciting career.
February 23, 2004
CLEAN
COAL
New technologies promise to deliver more electricity with zero emissions. So why
aren't they catching on?
MIDWEST BIOTECH
With
links to agriculture and medical devices, biotechnology holds tremendous promise for the
Midwest.
February 16, 2004
PHARMA INDUSTRY
Major
drug firms battle slump in new drug introductions by reorganizing and absorbing new tools for
discovery and development; companies also face external pressures on the public, political, and
regulatory fronts.
TRADING PLACES
In 2002,
more Ph.D. graduates studied chemistry-related fields rather than "classic" chemistry, more were
women, and more were minorities.
February 9, 2004
DEPRESSION
Although
depression is not completely understood, great strides have been made with various pharmaceuticals
to treat this multifaceted disorder.
TWO NEW ELEMENTS
In Russia,
an international research team has synthesized elements 113 and 115.
February 2, 2004
DIAMOND
SYNTHESIS
Man-made gem is more than just another pretty face; its remarkable properties
offer much for materials applications.
PACIFIC PARADISE
Good
living conditions and a rise in hiring attract people to schools in the Northwest.
January 26, 2004
SOAPS
AND DETERGENTS
Suppliers rethink strategies for active ingredient development, surfactant
producers scramble to restructure, and more firms turn to the Internet for collaboration.
January 19, 2004
CUSTOM
CHEMICALS
Companies grapple with how best to supply the pharma industry, as technology no
longer provides an easy differentiator and Asian competition grows.
WHAT'S THAT
STUFF?
Techniques for making or faking snow provide year-round fun.
January 12,
2004
WORLD CHEMICAL
OUTLOOK
Global chemical industry looks forward to a year of growth in most regions,
following increases in production and demand.
CRITTER CHEMISTRY
The homely
naked mole-rat may prove attractive for pain research.
MATERIALS SCIENCE EXHIBITION
Traveling science museum and website provide interactive experiences with
modern materials.
January 5, 2004
PRESIDENT'S MESSAGE
ACS
President Charles P. Casey addresses the many challenges facing chemists and how to convert these
challenges into opportunities.
CHEMICAL
TECHNICIANS
Technicians have become an integral part of both process and research
labs.
WHAT'S THAT
STUFF?
Champagne's characteristic effervescence is caused by fermentation and governed by
Henry's law.
This page updated December 20, 2004
December 20, 2004
CHEMISTRY HIGHLIGHTS 2004
Key advances were made this year in areas ranging from biochemistry, drug research, and analysis to nanotech and inorganic chemistry.
2004 INDUSTRY REVIEW
The upturn is no longer elusive, and although challenges remain, prosperity is finally returning to the chemical industry.
December 13, 2004
ACS Takes Legal Action Against Google
Google search service is said to infringe SciFinder Scholar
National Chemistry Week
This year's activities centered around the theme of "Health and Wellness."
December 6, 2004
PHARMA REVIEW
Competition from generics, pricing pressures, cost containment, and regulatory issues are among the problems the pharmaceutical industry is facing.
CONTRACT RESEARCH ORGANIZATIONS
CROs provide essential services and adapt to fit changing needs of pharmaceutical firms.
November 29, 2004
HUBBLE TELESCOPE
After 15 years, the aging instrument needs a serious tune-up, but the shuttle fleet that would do it is grounded.
DISPUTED HISTORY
Elias J. Corey's claim to have originated the idea behind the Woodward-Hoffmann rules is unfair, Roald Hoffmann says.
November 22, 2004
METABOLIC SYNDROME
Complex set of disorders offers drug development opportunities; a new NMR technique measures low-density lipoproteins.
November 15, 2004
ACADEMIC R&D
Latest NSF data from 2002 show marked growth in funding for chemical research.
November 8, 2004
RENEWABLE RESOURCES
Increases in the price of oil may drive specialty chemicals into a postpetroleum era.
November 1, 2004
EMPLOYMENT OUTLOOK
Amid record-high unemployment for chemists, C&EN offers advice on a new job hunt, midcareer transitions, and temporary jobs, as well as a salary review and information on job resources.
October 25, 2004
DIABETES DRUGS
Treatment paradigm involving peptide hormone receptor promises new hope for therapy.
October 18, 2004
PAINTS & COATINGS
Markets shift, regulations tighten, and the industry looks toward new technologies.
CHLORINE
C. T. Howlett Jr. and Terrence Collins debate chlorine's positive and negative contributions.
DREAM JOBS
C&EN examines what makes some companies leaders in employee relations.
October 11, 2004
PROCESS CHEMICALS
Specialty chemical strategies for the 21st century are clearly emerging in the concrete, dyes, paper, and leather
industries.
October 4, 2004
OCEAN ENERGY
Entrepreneurs hope to market clean, affordable electricity from the power of tides, waves, or any water in motion.
COMBICHEM
Modeled after natural products, diversity-oriented synthesis gives hope to a field in need of a boost.
MEDICAL DEVICES
Chemical engineers, like chemists, are in demand in this industry, which is thriving in New England.
September 27, 2004
HIGH-PERFORMANCE COMPUTING
Demand for computers of all sizes and designs is continually increasing for all kinds of problems in chemistry.
ACADEMIC SCORECARD
Women continue to be underrepresented in the faculty of top 50 chemistry departments.
September 20, 2004
STRUCTURAL PROTEOMICS
Biotechnology companies try to meet demand for contract research in this dynamic market.
POSTDOCTORAL EXPERIENCE
Four-part supplement discusses the challenges and opportunities facing today's postdocs, as well as a new education standardization in Europe.
September 13, 2004
NUCLEAR ENERGY
Next generations of reactors will have evolutionary and revolutionary designs.
September 6, 2004
FINE CHEMICALS
Suzuki coupling and related chemistries gain ground in commercial practice, from small-scale synthesis to industrial-scale production.
August 30, 2004
ADVANCED COMPOSITES
By blending distinct components, researchers make materials for auto, aerospace, defense, and other industries.
August 23, 2004
AGING
Scientists attempt to understand the triggers, timing, and molecular basis of this inevitable condition.
August 16, 2004
EMPLOYMENT & SALARY SURVEY
The job market for chemists continues to be difficult, but salaries have improved.
August 9, 2004
CARBOHYDRATE VACCINES
Novel techniques for constructing and synthesizing antigenic carbohydrates are making possible a new generation of vaccines.
August 2, 2004
DAVID KAY
Former head of CIA's weapons investigation group in Iraq discusses the lessons learned from the search for weapons of mass destruction.
July 26, 2004
DRUG DISCOVERY
Realism replaces hype as research scientists put high-throughput screening methods in their place.
July 19, 2004
GLOBAL TOP 50
Worldwide sales show a striking increase, but profits continue to slip.
CHEMRAWN XV
Conference in Paris spotlights chemistry???s global role in attaining safe and reliable water supplies.
COURTING CHEMISTS
Chemists' expertise is sought by medical device industry.
July 12, 2004
GREEN CHEMISTRY HONORS
Presidential honors recognize innovative chemical products and processes that prevent pollution.
July 5, 2004
FACTS & FIGURES
Chemical industry data for 2003 do not look very different from those of 2002--yet cost-cutting reorganizations of the previous few years are affecting the bottom line.
June 28, 2004
ELECTRONIC CHEMICALS
Sparked by higher demand, such as flat-screen TVs, the semiconductor materials business is booming once again as environmental concerns increase.
June 21, 2004
SOLAR ENERGY
With scientific breakthroughs on the horizon and production costs dropping, advocates say solar energy is on the cusp of a huge expansion.
WHAT'S THAT STUFF?
No-calorie sugar substitutes have sweetening powers hundreds of times that of sucrose.
June 14, 2004
CHIRAL CHEMISTRY
Traditional methods thrive because numerous hurdles, including tough luck, slow down the commercialization of catalytic processes.
WORLDWIDE SCIENCE
Growth in scientific papers is mostly in Europe and Asia.
June 7, 2004
BHOPAL
Twenty years later, Responsible Care has changed industry's approach to safety; third-party audits could help regain the public's trust.
CHEMISTS OF THE CARIBBEAN
Chemistry in the West Indies flourishes despite infrastructure and funding issues.
FLAVORS & FRAGRANCES
Chemists' work combines biology, chemistry, and psychology to create tempting products.
May 31, 2004
CONTROLLING MAD COW DISEASE
Malady presents a difficult regulatory challenge, in part because of gaps in the science of prion diseases.
THREE RINGS
Mix-and-heat strategy yields Borromean rings.
May 24, 2004
ANTIVIRAL DRUGS
Despite biological and economic challenges, a number of strategies are in the pipeline to fight viral respiratory infections.
MASS SPEC ASSAY
Strategy for rapid screening of chemical libraries yields inhibitor of anthrax toxin.
May 17, 2004
TOP 50 U.S. CHEMICAL PRODUCERS
C&EN's annual survey finds economic recovery lifting sales and profits, but a lack of deal making leaves the ranking little changed.
Killing Fat
Antiangiogenesis strategy targets fat cells and returns overfed mice to normal weight.
May 10, 2004
PROTEIN DRUGS
Rapid transformation in business and research has turned large drug firms into biotech players, while contract service firms move into life-cycle management.
May 3, 2004
PERSONAL CARE
Cosmetic makers seek new ingredients and formulations to mitigate effects of aging; FDA scrutinizes claims of therapeutic benefits.
COMBINATORIAL CHEMISTRY
Techniques are incorporated into the routine work of drug discovery.
April 26, 2004
CARBOHYDRATE CALCULATIONS
Despite their complexity, carbohydrates are finally yielding to the power of computational chemistry.
ETHICS EDUCATION
Colleges make an effort to fit research ethics into the curriculum.
WHAT'S THAT STUFF?
Kitty litter choices range from simple clays to silica gels to plant-derived alternatives.
April 19, 2004
SPECIALTY CHEMICALS
Key players explain how they have adapted to succeed in changing markets.
2003 STARTING SALARY SURVEY
Job market is still soft, median salaries have dropped, and number of unemployed has held steady.
April 12, 2004
NANOTECH IP
Broad potential of this "next big thing" has early developers looking to protect their intellectual property.
NANOTECHNOLOGY
Four Scientists offer advice on how to be a megastar employee in a nanoworld.
SCIENTIFIC PUBLISHING
Treasury office concedes that regulations on sanctioned countries do not involve U.S. publishing.
April 5, 2004
PHARMA OUTSOURCING
Four case studies of outsourcing relationships show that good service is rewarded with repeat business.
NANOKIDS
Project uses "character" molecules to draw students into science.
WHAT'S THAT STUFF?
Special adhesive developed by 3M has led to ubiquitous and indispensable sticky notes.
March 29, 2004
2004 PRIESTLEY MEDALIST
Nobel Prize winner E. J. Corey is honored for his profound contributions to organic chemistry and biomedical sciences.
DOWN THE YANGTZE
C&EN's Asia-Pacific correspondent reports on today's China as he continues down the Yangtze River.
AHA! MOMENTS: ROBERT R. BREAKER
Why doesn't nature use RNA molecules to sense specific metabolites and thus regulate gene expression? Nature does, Breaker thought, but no one realized it.
March 22, 2004
DATA MANAGEMENT
Amid a deluge of collected facts and figures, the chemical and pharmaceutical industries seek new information technology solutions.
CRITTER CHEMISTRY
A powerful neurotoxin from puffer fish provides pain relief for some cancer patients.
BIRTH OF A DRUG
Chemists in a variety of subdisciplines team with other scientists in the making of a new drug.
DOWN THE YANGTZE
Join C&EN's Asia-Pacific correspondent on his monthlong river journey to experience today's China.
March 15, 2004
PETROCHEMICALS
North American producers adjust to a changed industry, European producers consolidate, and Japanese producers receive a respite.
March 8, 2004
NITRIC OXIDE'S NEW PLAYER?
Researchers explore the chemistry of NO's biological alter ego, HNO.
March 1, 2004
DRUG DELIVERY
Companies emphasize products over platforms and are positioning their technologies earlier in the drug development timeline.
FORENSIC SCIENCE
It may not be as dramatic as popular TV shows portray, but painstaking chemical analysis is still an exciting career.
February 23, 2004
CLEAN COAL
New technologies promise to deliver more electricity with zero emissions. So why aren't they catching on?
MIDWEST BIOTECH
With links to agriculture and medical devices, biotechnology holds tremendous promise for the Midwest.
February 16, 2004
PHARMA INDUSTRY
Major drug firms battle slump in new drug introductions by reorganizing and absorbing new tools for discovery and development; companies also face external pressures on the public, political, and regulatory fronts.
TRADING PLACES
In 2002, more Ph.D. graduates studied chemistry-related fields rather than "classic" chemistry, more were women, and more were minorities.
February 9, 2004
DEPRESSION
Although depression is not completely understood, great strides have been made with various pharmaceuticals to treat this multifaceted disorder.
TWO NEW ELEMENTS
In Russia, an international research team has synthesized elements 113 and 115.
February 2, 2004
DIAMOND SYNTHESIS
Man-made gem is more than just another pretty face; its remarkable properties offer much for materials applications.
PACIFIC PARADISE
Good living conditions and a rise in hiring attract people to schools in the Northwest.
January 26, 2004
SOAPS AND DETERGENTS
Suppliers rethink strategies for active ingredient development, surfactant producers scramble to restructure, and more firms turn to the Internet for collaboration.
January 19, 2004
CUSTOM CHEMICALS
Companies grapple with how best to supply the pharma industry, as technology no longer provides an easy differentiator and Asian competition grows.
WHAT'S THAT STUFF?
Techniques for making or faking snow provide year-round fun.
January 12, 2004
WORLD CHEMICAL OUTLOOK
Global chemical industry looks forward to a year of growth in most regions, following increases in production and demand.
CRITTER CHEMISTRY
The homely naked mole-rat may prove attractive for pain research.
MATERIALS SCIENCE EXHIBITION
Traveling science museum and website provide interactive experiences with modern materials.
January 5, 2004
PRESIDENT'S MESSAGE
ACS President Charles P. Casey addresses the many challenges facing chemists and how to convert these challenges into opportunities.
CHEMICAL TECHNICIANS
Technicians have become an integral part of both process and research labs.
WHAT'S THAT STUFF?
Champagne's characteristic effervescence is caused by fermentation and governed by Henry's law.
This page updated December 20, 2004
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