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Science & Technology

December 21, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 33

COVER STORY: HYDROTHERMAL VENTS: 35

Geochemists probing the ocean subfloor find dynamic chemistry and hints of microorganisms at work.

UNUSUAL CLUSTER: 40

Hydrogenase crystal structure may aid design of industrially useful catalysts.

STUDENT JOURNAL: 41

National Journal of Young Investigators, in electronic format, gets undergraduates involved.

December 14, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 36

INTERNET SITES: 37

Some science-based web sites are labors of love.

CALIXARENES: 38

Molecular baskets are being redesigned to be receptors for specific tasks.

RESEARCH FUNDING: 41

Novartis to provide UC Berkeley with $25 million over five years.

December 7, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 39

COVER STORY: SELF-REPLICATION: 40

New experiments with peptide and nucleic acid chemistry may help to decipher molecular origins.

CARBENES AND NITRENES: 45

Character of elusive conjugated biradical intermediates is in hand at long last.

November 30, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 23

COVER STORY: BELL LABS: 24

Once a part of AT&T, technology innovator is now the R&D arm of Lucent Technologies.

OUCHLESS ADHESIVE: 29

Light-switchable bandage wins innovation award for British company.

SCIENCE INSIGHTS: 30

NIH science film festival capitalizes on teachable moments.

November 23,1998

SCIENCE/TECHNOLOGY CONCENTRATES: 37

PHOTONIC CRYSTALS: 38

Materials with arrays of large holes hold promise for development of optical-based technologies.

CHEMRAWN: 44

Conferences apply chemical research to the world's needs.

CHEMICAL SHIFTS: 46

Parameter important to NMR spectroscopy of proteins measured in solution.

November 16, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 30

HARVARD'S ICCB: 31

Institute for Chemistry & Cell Biology to provide a chemical interface between genomics, biology, and medicine.

WHAT'S THAT STUFF?: 35

Ink is a pervasive material that is essential to our everyday lives.

November 9, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 69

RIBOZYMES: 87

Two research groups independently unveil new catalytic RNA structures.

November 2, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 21

HEALING WITH LIGHT: 22

Photodynamic therapy holds promise for cancer treatment and other biomedical applications.

GENE ARCHITECTURE: 27

Cloned and characterized polyketide-antibiotic cluster may be useful in combinatorial biosynthesis.

October 26, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 36

ARTIFICIAL PHOTOSYNTHESIS: 37

Harnessing chemical systems that mimic natural processes could lead to a virtually infinite renewable supply of energy.

VANCOMYCIN: 46

Aglycon of this antibiotic is synthesized by two routes.

RESTORED VAN GOGH: 47

Restoration of dark-palette painting was aided by chemical analysis.

SCIENCE INSIGHTS: 48

Requirement to give Nobel Prize to no more than three people stirs up controversy.

October 19, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 42

NOBEL AFTERMATH: 45

Fame that comes with winning a major science prize can disrupt research as well as everyday life.

PHOTOCHEMISTRY: 47

Sunlight influences interplay of radicals and trace metals in ocean water.

October 12, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 36

DERMAL EXPOSURE: 37

Model uses data from human activity recorded on videotape to determine extent of exposure to toxics.

BIMETALLIC CATALYST: 40

Chemists have encapsulated highly dispersed nanoparticles inside the pores of a silica support.

October 5, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 41

G-QUADRUPLEXES: 42

Folded DNA structures attract growing interest as targets for therapeutic agents for treatment of cancer.

POLYPROLIFERATION: 46

Polysaccharides, polycarbonates, and polyetheresters prepared by new approaches.

September 28, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 23

COVER STORY: NMR BLOSSOMS: 25

Modeling of chemical shifts increases ability to predict the structures of even complex molecules.

SCIENCE INSIGHTS: 37

Does androstenedione give Mark McGwire extra oomph?

September 21, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 56

CHEMICAL SENSITIVITY: 57

Is it stress, imagination, or a real disease? Medical proof is elusive.

NANOMANIA: 70

Materials structures with at least one dimension smaller than 100 nm capture chemists' fancy.

NEURODEGENERATION: 78

Oxidative stress, role of NO are common characteristics of disease processes.

NUCLEIC ACID POLYMERS: 80

Designed biopolymers copied and amplified like DNA, but have chemical functionality of proteins.

September 14, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 28

COMBINATORIAL CHEMISTRY: 29

Researchers harness microorganisms to carry out combinatorial syntheses.

ANALYZING THE OCEAN: 31

Requires innovative analytical and sampling techniques.

September 7, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 30

COVER STORY: CHEMISTRY AND ART: 31

Scientists bring their expertise to bear on repair and restoration of synthetic materials.

FOOD ALLERGIES: 38

Proteins are the root of the problem for most sufferers; modifying plant genes may be a future solution.

PROCESS RESEARCH: 41

Chemists face myriad challenges to develop practical, efficient, and cost-effective large-scale syntheses.

August 31, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 23

PEPTIDE TWIST: 24

New kinds of peptide derivatives adopt defined helical folding patterns in solution.

ALLOSTERIC MODIFIERS: 25

Small-molecule drugs that bolster oxygen delivery are being developed to fight ischemic diseases.

SCIENCE INSIGHTS: 27

Who would guess that chemists can find joy in cement?

August 24, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 49

PROTEIN PROGRESS: 51

Advances in protein science were discussed at a recent symposium.

August 17, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 37

PHOSPHORUS DAZZLES: 38

International conference highlights new phosphorus-containing drugs and novel P-P half bonds.

MUNCHING ON TNT: 40

Spinach enzymes degrade explosives to potentially useful chemicals.

August 10, 1998

SCIENCE/TECHNOLOGY CONCENTRATES: 51

BREAST IMPLANTS: 53

Institute of Medicine committee charged with reviewing, clarifying safety data.

PROTEIN NMR: 55

Variation on correlation technique allows spectra of molecules 100 kilodaltons and larger in size.

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