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December 18, 2000
Science/Technology Concentrates
COVER STORY: Chemistry Highlights 2000
Year-end recap highlights some key developments in chemical research.
Supercritical CO2
Dense fluid's talents as a solvent for materials R&D go beyond environmental correctness.
December 11, 2000
Science/Technology Concentrates
New Lab at Oxford
Chemistry department strikes innovative deal with venture capitalist to finance construction of $100 million lab.
R&D Paradigm Shift
Industrial R&D emphasizes alliances, moves from improvement of existing products to creation of new ones.
Most Proficient Enzyme
Orotidine 5'-monophosphate decarboxylase owes its effect to transition-state stabilization.
"Molecular Break Lights"
Fragments of hairpin-shaped DNAs break off and light up in the presence of DNA-cleaving agents.
Taxol Biosynthesis
Four research groups reveal remarkable single-step mechanism.
December 4, 2000
Science/Technology Concentrates
Electrochemists on Stage
Electrochemical Society meeting serves up discussions on physical and biological applications.
Quest for Diels-Alderases
Two groups home in on natural enzymes that may catalyze Diels-Alder reactions.
Nobel Centennial Symposium
Laureates discuss what it takes to win the Nobel Prize in Chemistry.
Cell Signaling
X-ray structure of FHA domains reveals clues about mechanisms of cellular communication.
What's That Stuff?
The manufacture of chocolate relies heavily on science and technology.
November 27, 2000
Science/Technology Concentrates
MS of Proteins
Mass spectrometry is carving out a complementary role to determine secondary and tertiary protein structure.
Novel Ketone Synthesis
Palladium-catalyzed coupling of thiol esters with boronic acids gives ketones under mild conditions.
What's That Stuff?
There's nothing silly about the chemistry behind the putty that has amused children for 50 years.
Science Insights
Recent publications that compile examples of good science writing lack chemistry contributions.
November 20, 2000
Science/Technology Concentrates
Iron-Sulfur Proteins
Electron transfer isn't the only role of inorganic clusters in these biological molecules.
Silicon Surface Chemistry
Seesaw motion of silicon dimers provides key to energetic puzzle of hydrogen bonding.
November 13, 2000
Science/Technology Concentrates
Plant Biochemistry
Discovery of guiding proteins reshapes thinking in the field of lignin and lignan biosynthesis.
Tom and Jerry
Collaboration between a chemist and a naturalist provides insight into the chemical language of nature.
Fluorescent Protein
Assay based on protein splicing allows detection of protein interactions.
November 6, 2000
Science/Technology Concentrates
COVER STORY: Quantum Computers
Researchers call on chemists to help them tame the slippery quantum world.
Natural Products
High quality of Brazil's research is highlighted at a conference there.
October 30, 2000
Science/Technology Concentrates
Natural Products
Novel synthetic strategy yields combinatorial libraries.
Science Insights
Controversy surrounds approval of RU-486, while contraceptive R&D remains stagnant.
October 23, 2000
Science/Technology Concentrates
COVER STORY: Chiral Drugs
New intermediates, catalysts, and reactions fuel continued industry growth.
New Lasers
Nanocrystal quantum dots show lasing capabilities.
Macromolecules' New Editor
Timothy Lodge to take the helm in January 2001.
October 16, 2000
Science/Technology Concentrates
Cellular Signaling
Scientists aim to employ big science approach to solve intractable problems of intracellular communication.
October 9, 2000
Science/Technology Concentrates
Multivalency
Multiple interactions between ligands and receptors greatly improve binding affinity.
Ethics of Gene Therapy
Report calls for independent oversight committee to monitor research on modifying inheritable genes.
Type 2 Diabetes
Gene has been found that affects susceptibility in some populations.
October 2, 2000
Science/Technology Concentrates
Extremely Cold Chemistry
Exotic and unusual behavior of atoms and molecules is being explored by ultralow-temperature spectroscopy.
Targeting RNA
Search grows for small molecules that interact with RNA.
September 25, 2000
Science/Technology Concentrates
COVER STORY: Computational Chemistry
Helping scientists make sense of genomics protein avalanche.
Heparin Sequence
Polysaccharide sequencing yields accurate data on heparin fragment.
Sweet Achievement
Efficient, high-yield synthesis of sucrose has been developed.
Science Insights
Despite a good drug-testing system, athletes can still escape sanctions.
September 18, 2000
Science/Technology Concentrates
COVER STORY: Drug Delivery
New technologies for administering medicines improve convenience, performance, and patient compliance.
Controlling CO2 Emissions
Researchers discuss the feasibility of large-scale CO2 sequestration.
September 11, 2000
Science/Technology Concentrates
Controlling Pests
Tailor-made controlled-release formulations can time pesticide releases ranging from hours to decades.
Explosives Detection
Analytical chemists seek better methods to trace explosives before and after their use.
September 4, 2000
Science/Technology Concentrates
Lab Scale to Production
Process chemists often have to adjust syntheses--but sometimes they must craft entirely new ones.
BINOL and BINAP
Researchers continue to tweak these ligands to fine-tune the properties they impart to catalysts.
Transmembrane Barrels
Nanostructures have enough room to host double-stranded DNA.
World's Smallest Single Crystal
One-dimensional KI crystals are grown inside carbon nanotubes.
Hydrophosphorylation
Technique's revelation is a synthetic sensation.
August 28, 2000
Science/Technology Concentrates
COVER STORY: Safeguarding Venice
Scientific efforts are key in saving the city and its lagoon from pollution and rising waters.
Cyclohexatriene
Experimentally determined heat of hydrogenation of embedded ring is consistent with theory.
Bacteriorhodopsin
Light-activated proton pump helps explain more complex molecular machines.
Inhibiting Cell Signaling
Researchers have designed, synthesized, and characterized a potential osteoporosis drug.
August 21, 2000
Science/Technology Concentrates
Molecular Costraints
Researchers are investigating how confined spaces influence reaction pathways.
August 14, 2000
Science/Technology Concentrates
Electronic Journals
Young German and U.S. chemists gather at a monastery in Germany to discuss cutting-edge research.
Carotenoids
Three research groups developed genetic engineering techniques to obtain these colorful antioxidants.
Protein Interactions
Atomic force microscopy yields dramatic movies of protein molecules.
Explosive Cation Tamed
Stable salt of N5+ has been prepared and crystallographically characterized.
What's That Stuff?
From ancient Egypt to dollar bills, people have relied on paper.
August 7, 2000
Science/Technology Concentrates
Talking Chemistry
Young German and U.S. chemists gather at a monastery in Germany to discuss cutting-edge research.
Remembering Linus Pauling
Nobel Laureate's meticulous record keeping has yielded a powerful legacy.
July 31, 2000
Science/Technology Concentrates
COVER STORY: Proteomics
Study of the protein universe of cells is poised to pick up where genomics--and the completed DNA sequence--leaves off.
Science Insights
Connectedness of knowledge is profoundly relevant to the teaching and learning of science.
July 24, 2000
Science/Technology Concentrates
Visualizing Genetic Variation
Carbon-nanotip atomic force microscopy is used to image markers on DNA in promising diagnostics method.
Magically Encoding
"Lucky charms" combinatorial technique is based on solid-phase material in breakfast-cereal shapes.
Molecular Ink
Localized reactions imprint structures of molecules on underlying substrates.
Making Nanotools
Symposium explores how NIH can commit to nanofabrication development.
July 17, 2000
Science/Technology Concentrates
Enzyme Dynamics
Insights on effect of motion on enzyme activity result from meeting of theorists and experimentalists.
July 10, 2000
Science/Technology Concentrates
Green Chemistry
Presidential awards recognize environmentally friendly technologies.
Alzheimer Enzyme
Scientists are homing in on the elusive enzyme involved in generating Alzheimer peptide.
July 3, 2000
Science/Technology Concentrates
COVER STORY: Thomas R. Cech
President of Howard Hughes Medical Institute has developed a new vision for top biomedical funding foundation.
Combinatorial Synthesis
Spot method is an approach for synthesizing and screening libraries on paper or other solid supports.
Harnessing Robots
High-throughput style of doing research proves ideal for protein crystallization.
June 26, 2000
Science/Technology Concentrates
Biomaterials
Researchers are following diverse paths to safe materials to repair and replace parts of the human body.
Temporomandibular Joint Disorders
Poorly understood problem receives multidisciplinary attention.
Protein-Protein Interactions
Scientists find small-molecule "switches" that may help regulate physiological processes.
Science Insights
Giving birth to a science article can be arduous, but the labor yields rich rewards.
June 19, 2000
Science/Technology Concentrates
COVER STORY: Starting Out
Seven assistant professors share the successes and pitfalls of beginning an academic career.
ACHEMA 2000
Germany's huge triennial exhibition and congress highlights the future of chemical technology.
June 12, 2000
Science/Technology Concentrates
COVER STORY: Data Storage
Chemists are working at the forefront of making computers faster, smaller, and able to store more data.
What's That Stuff?
Self-tanning products: Why your perfect tan is made in the shade.
June 5, 2000
Science/Technology Concentrates
COVER STORY: Drug Discovery
Identifying dead-end lead compounds early would cut costs and shorten time of drug development.
Art Conservation
Spectroscopy provides a means to identify the pigments in a work of art.
May 29, 2000
Science/Technology Concentrates
ESR for Peptides
Electron spin resonance with unnatural amino acid as a spin label provides a new twist for structural analysis.
Science Insights
Strong actions are needed to eliminate tuberculosis in the U.S. by 2035.
May 22, 2000
Science/Technology Concentrates
COVER STORY: AHMED ZEWAIL
1999 Chemistry Nobel Laureate is constantly pushing the boundaries of femtochemistry.
"FROG FUGUE"
Science-inspired artwork is inspiring science at a University of Wisconsin lab.
May 15, 2000
Science/Technology Concentrates
IONIC LIQUIDS
NATO workshop examines the industrial potential of green chemistry using room-temperature "designer solvents."
ASYMMETRIC C-C BONDS
50 Four components added to one pot generate compound with two chiral centers.
May 8, 2000
Science/Technology Concentrates
COVER STORY: CHIRAL CHEMISTRY
Industry continues to adapt new methodologies as fast as academic researchers can dream them up.
CHEMISTRY/BIOLOGY
Symposium celebrates chemists' deep involvement with modern biology.
BLACK CHEMIST'S MEETING
Annual NOBCChE conference highlights tools for success in the new millennium.
May 1, 2000
Science/Technology Concentrates
ALL IN GOOD TASTE
Flavor is a complex sensation affected by many stimuli.
PROCESS CHEMISTRY
Symposium exposes chemists to the anatomy of product development.
April 24, 2000
Science/Technology Concentrates
COVER STORY: COMPUTERS OF THE FUTURE
Computers hold great promise for solving huge chemical problems.
SYNTHETIC BIOLOGY
Researchers are using organic chemistry to design nonnatural molecules that function in biological systems.
SCIENCE INSIGHTS
Why news about the latest genome milestones does not appear in C&EN.
April 17, 2000
Science/Technology Concentrates
COVER STORY: ORGANICS ON SEMICONDUCTORS
Adding molecular function to semiconductor surfaces could lead to an array of new electronic devices.
POLYMER SCIENCE
Symposium showcases hot new areas of research, identifies best opportunities for progress.
April 10, 2000
Science/Technology Concentrates
DRUGS IN THE ENVIRONMENT
Little is known about the impact that traces of post-use pharmaceuticals and personal care products may have.
GRISEOVIRIDIN SYNTHESIS
Using L-amino acid to make natural product incorporating d form doesn't work.
HAROLD JOHNSTON HONORED
Division of Physical Chemistry symposium celebrates atmospheric chemist's 80th birthday.
April 3, 2000
Science/Technology Concentrates
PLAYING IT COOL
Cutting-edge materials science, new uses for familiar substances advance chemistry-related cooling technologies.
March 27, 2000
Science/Technology Concentrates
GOOD NICOTINE
Alkaloid offers route to treating Tourette's syndrome, new hope for other brain disorders.
CELL-SURFACE CHEMISTRY
Method to install azides offers new way to attach moieties to cell surfaces.
SCIENCE INSIGHTS
It's a daunting task to select the chemistry news each week for C&EN.
March 20, 2000
Science/Technology Concentrates
PROTEASOME'S PROGRESS: 43
Scientists devise new mechanistic model, find selective inhibitor, and test drugs targeted to key protein-degrading complex.
GREEN CATALYST: 48
Palladium complex works with air to oxidize alcohols in water.
March 13, 2000
Science/Technology Concentrates
SUPERSTAR ENZYME: 42
Highly proficient orotidine 5'-monophosphate decarboxylase fascinates enzymologists and chemists.
ENEDIYNES: 47
Research on these bacterial natural products shows promise.
AN ENZYME MOVIE: 50
Snapshots of the structures of unstable intermediate complexes help explain how a cytochrome P450 works.
WHAT'S THAT STUFF?: 52
Hair coloring involves some serious chemistry on your head.
March 6, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 39
COVER STORY: ANTIBIOTIC RESISTANCE: 41
Specter of ineffective drugs prompts drug and biotech firms to seek new weapons to battle infections.
NAACP BOYCOTT: 58
ACS polymer workshop relocates in response to South Carolina Confederate flag issue.
PERKIN MEDALIST: 60
Norman Li honored for his invention of liquid membranes and innovations in facilitated-transport separations.
February 28, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 33
COVER STORY: NASA GOES NANO: 36
Space agency hitches its star to nanotechnology for designing future missions to explore the solar system and beyond.
EDITOR FOR NEW JOURNAL: 43
Robin Rogers is chosen to head ACS's Crystal Growth & Design, which will debut in January 2001.
SCIENCE INSIGHTS: 44
National implant registry could help decrease the number of patients harmed by faulty devices.
219TH ACS NATIONAL MEETING
Listing of technical presentations and description of exhibitors in San Francisco.
February 21, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 26
NANOSCIENCE SCALES UP: 27
Research center in Germany aims to promote interdisciplinary research in nanotechnology.
PROTEIN-LIGAND BINDING: 30
New NMR-based technique shortens time to determine structures of protein-ligand complexes.
GENES ON, GENES OFF: 34
Designed proteins act like transcription factors to control genes in living cells.
ENZYME ACTIVITY TO GO: 35
British researchers modify a natural enzyme to order, giving it a new catalytic function.
February 14, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 79
PROTEOMICS CONFERENCE: 81
International experts address how genome sequences might best be analyzed, archived, and used.
PITZER TRIBUTE: 84
Late scientist's colleagues convene a conference on theoretical chemistry.
ENZYME COOPERATION: 86
X-ray crystal structure of DNA repair enzyme APE1 provides insight into enzyme pathways.
February 7, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 40
IR AND RAMAN DIMENSIONS: 41
New multidimensional techniques complement NMR for elucidating structures of large molecules.
WHAT'S THAT STUFF?: 51
Process cheeses have become ubiquitous foodstuffs; just what are they?
January 31, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 24
MACARTHUR FELLOWS: 25
A close look at the lives of three women chemists singled out for exceptional creativity and promise.
BOND SURGERY: 36
Finely tuned X-rays can cleave specific bonds in nitrogen molecules affixed to metal surfaces.
RICHARD A. LERNER: 37
C&EN talks with the president of Scripps Research Institute about proposed University of California-based research institutes.
SCIENCE INSIGHTS: 38
Putting in perspective recent failures in NASA's missions to Mars.
January 24, 2000
MESOPOROUS HYBRIDS: 33
New materials feature organic functionality within a solid-state inorganic framework.
FRAGILE FRESCOES: 35
Restorers use subtleties of chemistry to develop methods for preserving Florentine art treasures.
January 17, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 48
University of Georgia chemists focus on quantum mechanics and drug design, find synergy in new facility.
January 10, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 26
COMPUTER CLUSTERS: 27
Systems made by hooking together several PCs can crunch data like supercomputers at a fraction of the cost.
IMPRINT CATALYSTS: 31
Technique combines organometallic catalysis, molecular imprinting of polymers.
WOMEN IN SCIENCE: 33
New mechanisms could help improve status in academia.
January 3, 2000
SCIENCE/TECHNOLOGY CONCENTRATES: 21
'MOLETRONICS': 22
Organic molecules, metallic nano- wires are being considered for nanoscale electronics technology.
NEAR-CRITICAL WATER: 26
Unique properties allow water to serve as solvent, reactant, and catalyst in organic reactions.
SCIENCE FOR THE PEOPLE: 27
U.K. chemist is honored for helping the public appreciate science.
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