December 23, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

OLEFIN METATHESIS

While hoping for better prospects, chemical companies struggled through an uncertain 2002 by restructuring their businesses and shifting operations.

MICROCHIPS AND THE ENVIRONMENT

Life-cycle analysis shows microchips consume a disproportionate amount of energy and water.

INSIGHTS

Art and science meet when art students nurture seedlings for an experiment designed to "reverse-engineer" crops.

December 16, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CHEMISTRY HIGHLIGHTS 2002

Important chemical advances in a range of areas--from organic synthesis to attosecond spectroscopy--were achieved this year

PAIN-RELATED ENZYME

Researchers design inhibitor drug that thwarts a hydrolase responsible for pain sensation.

WHAT'S THAT STUFF?

Erasers are simple tools yet are full of chemistry.

DIGITAL BRIEFS

December 9, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

MEETING EARTH'S CHALLENGES

National Research Council workshop focuses on environmental topics of interest to chemists.

VICTORIA BRAGIN

C&EN talks with Van Cliburn piano competition cowinner and chemistry educator.

December 2, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

COMPOUND LABELS

IUPAC has developed a system to derive unique and unambiguous chemical identifiers from graphical structural information.

November 25, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

GREEN CHEMISTRY

As pollution prevention strategy matures, the world community will expect quicker solutions to sustainability problems.

WOMEN IN CHEMISTRY

Angela Belcher's passion is to create and organize new materials using templates from the natural world.

INSIGHTS

In just a few weeks, Scripps Research Institute scientists had a remarkable string of scientific events. How do they do it?

DIGITAL BRIEFS

New Software And Websites For The Chemical Enterprise

November 18, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

THREE NOBEL WINNERS

A further look at the bioanalytical research of John Fenn, Koichi Tanaka, and Kurt W?thrich, who received the 2002 Nobel Prize in Chemistry.

NEW PRODUCTS

New And Notable In The Chemical Industry

November 11, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

COMBINATORIAL CHEMISTRY

Established drug discovery technology is refined with advances in synthesis, purification, and analysis. New government center helps industry develop high-throughput methods to measure materials properties of polymers.

PROCESS CHEMISTRY

Group formed 10 years ago to further R&D celebrates its anniversary.

WHAT'S THAT STUFF?

Chemical preservatives help foods stay fresh.

DIGITAL BRIEFS

New Software And Websites For The Chemical Enterprise

November 4, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

ANALYZING MISCONDUCT

Recent cases of research fraud bring up questions of coauthor responsibility, trust, and objectivity.

October 28, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

PAUL WENNBERG

C&EN talks with the latest chemist winner of the MacArthur Foundation Fellowship.

EDUCATION INITIATIVES

Despite the slow spread of reform, NSF funds a palette of programs for the chemistry classroom.

INSIGHTS

Germans appear to live comfortably while integrating energy and resource conservation into their daily lives.

October 21, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

ARSENIC IN BANGLADESH

Scientists from around the world team up to help understand and address a drinking-water crisis.

NEW PRODUCTS

October 14, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

GENOMICS REVOLUTION

Methods to validate targets are key to success of drug developers.

"DUDFEST 2002"

Special Harvard symposium celebrates 70th birthday of Nobel Laureate Dudley Herschbach.

October 7, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

NOBLE-GAS CHEMISTRY

Forty years after the first noble-gas compound was discovered, scientists still make surprising discoveries in the field.

CLEANING UP FOSSIL FUELS

Energy R&D programs focus on low-emissions electricity generation and ultraclean gasoline.

September 30, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

NANOELECTRONICS

Further miniaturizing today's already small electronic circuits will lead to faster, more sophisticated, and more portable devices.

CELL SIGNAL SLEUTHS

Small molecules and chemical methods help piece together signal transduction pathways.

NEW PRODUCTS

September 23, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CENTENARIAN CHEMIST

Ray Crist, 102, has had an impressive career, and he's not done yet.

DIGITAL BRIEFS

New Software And Website For The Chemical Enterprise

September 16, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

COMPUTERS IN THE CLASSROOM

Students learn the tools and techniques of computation and modeling with software and online educational systems.

BIOORGANOMETALLIC CHEMISTRY

Nascent field may yield important compounds related to medicine, catalysis, and sensing.

FINE-TUNING CATALYSTS

Improving catalysts at the nanoscale leads to large-scale benefits in efficiency and yield.

IMMUNOSUPPRESSANTS

Crystal structure of complicated drug-protein-enzyme complex is deciphered.

September 9, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

RADICAL POLYMERIZATION

Recent advances in the field are leading to controlled, versatile growth of polymers.

GLUCOSE MONITORING

Analytical chemists and engineers are developing ways to monitor glucose that would cut down on finger pricking.

September 2, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

COMBINATORIAL CHEMISTRY

In libraries that are mixtures of organic compounds, template molecules bind tightly to and stabilize fittest hosts.

DESTROYING PESTICIDES

ACS symposium spotlights methods for safe disposal of toxic chemicals.

August 26, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

DRUG DELIVERY

Scientists are refining old materials and exploring a wide variety of new ones to address next-generation drug delivery needs.

DUKE'S FIRST-YEAR STRUGGLE

Experimental freshman chemistry course is put on hold after a frustrating launch.

WOMEN IN CHEMISTRY

Valerie Sheares at Iowa State University balances teaching, service, and research.

INSIGHTS

New Mexico State University, Las Cruces, is developing a forward-looking chemistry program in its high desert environs.

August 19, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

J. CRAIG VENTER

One of the most visible scientific personalities of our time discusses the past and future of genome mapping.

A NOBEL MEETING

In Lindau, Germany, 600 young researchers mingle with Nobel Laureates.

PEPTIDE STRUCTURES

For the first time, researchers use solid-state NMR to determine 3-D configuration of a peptide.

PRION DISEASES

Tetracyclines might be a relatively nontoxic means of treating prion-related diseases.

August 12, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CHEMISTRY TRICENTENNIAL

Cambridge University's chemistry department celebrates 300 years of rich history featuring famous names and important discoveries in the field.

AMYLOID DISEASE

Precursors of insoluble amyloid fibrils may kill neurons in patients with age-related diseases.

VINLAND MAP

Recent report on authenticity of historical document adds another chapter to this controversy.

WHAT'S THAT STUFF?

Licorice's unusual chemistry and medicinal properties make it more than just a sweet treat.

August 5, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

ATOMIC-SCALE EXPLORATIONS

Researchers increasingly use transmission electron microscopy for garnering information from chemical systems.

WHAT'S THAT STUFF?

Bug off! Sprays use a variety of synthetic and natural ingredients to get rid of insects.

July 29, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

DANFORTH PLANT SCIENCE CENTER

Interdisciplinary research guides this midwestern facility in addressing agricultural problems in industrialized and developing countries.

PHOTO EXHIBITION

Scientific images are shown alongside famous European artwork at Oxford.

ADVANCED REACTOR DESIGN

Refined rotor-stator system could boost chemistry process intensification efforts.

INSIGHTS

DNA , even when used to synthesize infectious poliovirus, is no more alive than other molecules.

July 22, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

FINE CHEMICALS

Although still suffering from overcapacity and low demand, this industry will fare a little better than it did in 2001.

MIMICKING HYDROGENASE

Enzyme's complex method of oxidizing hydrogen may give industry some ideas for cheaper catalysts.

NEW PRODUCTS

July 15, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

ASTROCHEMISTRY

Exciting chemistry takes place in interstellar clouds, where chemical reactions occur in the gas phase, on the surfaces of particles, and in the ice layers.

ALL WRAPPED UP

Researchers dissolve nanotubes in water by encasing them in carbohydrates such as starch and gum arabic.

July 8, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CRYSTAL CAPTOR

Calixarene traps gases and holds them, even at high temperatures.

CAMPUS SECURITY

Chemistry departments are increasing the guard on their facilities and materials in light of Sept. 11.

ALCHEMICAL ART

Entrepreneur Roy Eddleman contributes his collection--nearly 50 paintings and engravings--to the Chemical Heritage Foundation.

MOLECULAR ROTATORS

UCLA group creates a class of molecules that rotate like gyroscopes.

July 1, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

GREEN CHEMISTRY AWARDS

Chemists and chemical engineers receive presidential recognition for innovations that promote pollution prevention.

June 24, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

HIGHER LEARNING

Spiro Alexandratos faces challenge of building the City University of New York's research program.

QUADRUPLEX DNA

Two research groups propose structures to define the configuration of human telomeres.

WOMEN IN CHEMISTRY

Louisiana State's Julia Chan orchestrates a life rich in chemistry and music.

WHAT'S THAT STUFF?

Chemical protectants in sunscreen allow us to have fun in the sun, sans the burn.

June 17, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

ENDOHEDRAL FULLERENES

They aren't easy to prepare or study, but researchers are getting closer to understanding and exploiting the unique properties of these fascinating molecules.

CHIRAL CATALYSIS

Nonlinear effects in asymmetric reactions create surprises in both reaction yields and rates.

PROTEIN ELECTROSTATICS

Researchers develop novel amino acid for probing polarity and solvation properties.

NEW PRODUCTS

June 10, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CHIRAL CHEMISTRY

Pharmaceutical suppliers hope to profit from growing demand for single-enantiomer products; scientists seek new methods for improving the yields of chiral reactions.

ANTIMICROBIAL SURFACES

Chemists incorporate bactericidal treatments into clothing, paper, glass, and plastics.

HINDSIGHTS

Biennial NSF report, "Science & Engineering Indicators," documents the changing U.S. scientific workforce.

DIGITAL BRIEFS

June 3, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CATALYSIS IN THE NETHERLANDS

Leadership role is result of company density, cooperation, diverse programs, and strong industry-academic relationships.

PNAS

National Academy of Sciences seeks to broaden the fields covered in its biweekly journal.

CHIRAL COMPOUNDS

Two independent research groups discover the same -amination of unmodified aldehydes.

May 27, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

ALTERNATIVE FUELS

Vegetable-oil-derived biodiesel, a cheap and plentiful alternative to petroleum products, is rising in popularity.

OBSERVING CATALYSIS

Chemists use enzymes to monitor reaction rates in real time.

INSIGHTS

The future of scientific literacy depends on simple actions taken today.

May 20, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

GREEN CHEMISTRY GETS GREENER

Catalysis, agriculture are part of myriad efforts to expand environmentally benign practices

PUTTING SAFETY FIRST

Accidents spark some researchers to switch to safer method of purifying organic solvents WHAT'S THAT STUFF?

NEW CAR SMELL

VOCs account for the characteristic 'newness'

NEW PRODUCTS

May 13, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

DRUGS WITH PROMISE

Companies reveal the structures and actions of drugs in clinical-trial pipelines.

ENZYME INSIGHTS

Researchers begin to decipher how phosphoryl-transfer enzymes combine catalysis with regulation and control.

REACTION WELLS

In at least one instance, intermediates avoid the energy minimum predicted by statistical mechanics.

May 6, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

POLYELECTROLYTE MULTILAYERS

Thin-film properties can be finely tuned through layer-by-layer assembly

MILLENNIAL ANALYSIS

Analytical chemists look into their crystal balls to glimpse future instrumentation needs

HELPING THE PUBLIC TO UNDERSTAND SCIENCE

Vega Science Trust provides a TV and Internet broadcast platform for scientists and engineers

WOMEN IN CHEMISTRY

Strong and healthy, the bioinorganic field provides supportive environment

HOW TO GET SOMEONE TO READ YOUR PAPER

JACS authors seek to attract readers' notice with eye-catching graphics in the table of contents

April 29, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

ENSURING THAT TESTS MEASURE UP

Regulators may need to reexamine the validity of environmental assays

PRION DIAGNOSTICS CONTINUE TO ADVANCE

Researchers report progress in techniques for diagnosing deadly prion diseases

CHEMISTRY GOES TO THE DOGS

Developing analytical methods for forensic science goes hand-in-hand with detector dogs

ELUSIVE CARBOCATION ISOLATED AS A SOLID

Pentamethylcyclopentadienyl cation is found to be a stable singlet with a distorted structure

MEETING BRIEFS

ANOTHER DIGITAL DIVIDE

Web access to the scientific literature is changing librarians' role as archivists

PICKING THE WINNERS

ADME/Tox computational screening early in the process could make drug discovery more effective and much less costly

April 22, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

GREEN PHARMA

Symposium attendees learn how chemistry that's good for the environment is also good for the bottom line.

CELEBRATING DIVERSITY

National Organization for the Professional Advancement of Black Chemists & Chemical Engineers turns 30 and honors its origins.

WOMEN IN CHEMISTRY

Yale professor Alanna Schepartz enjoys mentoring as much as researching chemical biology.

April 15, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

MERCURY PRECIPITATION

Depletions of tropospheric mercury may not be confined to the poles.

IMAGING NANOWIRES

Combination of near-field microscopy and nonlinear spectroscopy gives a clearer view of nanowires.

WHAT'S THAT STUFF?

Shampoo products all have one thing in common: They contain a fusion of chemical ingredients to clean hair.

April 8, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

PITTCON 2002

Despite decline in conference attendance, technical program remains as strong as ever, covering advances in biological and chemical weapons sensors, proteomics, miniaturized mass spectrometry, NMR, and more.

2002 PRIESTLEY MEDALIST

Prolific electrochemist, respected teacher, and long-time JACS editor Allen J. Bard is honored for 40 years of discovery and service to the scientific community.

April 1, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

NORMAN HACKERMAN

Prolific chemist and university administrator is still going strong at age 90.

THE SIMPLEST REACTION

New experiment matches quantum theory predictions for hydrogen-exchange reactions.

LOKER INSTITUTE CELEBRATION

University of Southern California commemorates 25th anniversary of an innovative center for hydrocarbon research.

March 25, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CATALYTIC CLEANUP

Paper mill pollution is turned into money-making products.

INSIGHTS

Business strategy of tuberculosis alliance could serve as a model for meeting neglected public needs.

March 18, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

MARK WRIGHTON

Top-notch chemist is excelling at his job as chancellor of Washington University.

PROTEOMICS

Deciphering the human proteome may prove a far messier proposition than decoding the human genome.

LAB SAFETY

Professor's termination over safety issues raises controversy about university standards, tenure.

CARBORANES FOR NUCLEAR MEDICINE

Synthesis of technetium and rhenium compounds broadens scope of radiopharmaceuticals.

March 11, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

PERKIN MEDALIST

Medicinal chemist Paul Anderson is honored for his leadership in drug discovery.

March 4, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

PROCESS INTENSIFICATION

Fine chemicals manufacturers adopt strategies to concentrate and accelerate operations and procedures.

ALKENE METATHESIS

Environmentally benign ionic liquids allow ring-closing reaction and recycling of ruthenium catalyst.

February 25, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CATALYSIS

Proline catalyst may lead to environmentally benign version of asymmetric Mannich reaction.

SCIENCE INSIGHTS

Better understanding of the technology underlying our lives should be a priority for education.

February 18, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

DRAPER PRIZE

Robert Langer's work on biomaterials, controlled drug release, and tissue engineering garners him "engineering's Nobel Prize."

February 11, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CATALYSIS

Scientists begin to decipher how living systems process silicon.

February 4, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

REFINING C–H BOND ACTIVATION

Iridium catalyst systems hold promise for improved C???C coupling reactions.

January 28, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

NOBEL JUBILEE

Scientists gather in Sweden to celebrate 100 years of the Nobel Prize by looking to the future of molecular science.

PERSPECTIVE

Process for choosing Nobel Prize winners follows strict guidelines.

SPECTROSCOPIST BROOKS PATE

SciDev.Net and ACS's International Activities Committee seek to facilitate the developing world's access to scientific knowledge.

INSIGHTS

MacArthur Foundation fellowship winner has a plan to expand spectroscopy research.

January 21, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

HIDING IN PLAIN SIGHT

"Atomic XAFS" yields new chemical information from previously neglected region of X-ray absorption spectrum.

SUGAR CONNECTION

Carbohydrate ligands play a role in antibody production and bacterial migration.

WOMEN IN CHEMISTRY

UC Berkeley's Carolyn Bertozzi uses her organic chemistry training to unravel biological problems.

CARBOHYDRATE VACCINES

Researchers accelerate process for automated synthesis of oligosaccharides for medical applications.

January 14, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

CHEMISTRY IN MEDICINE

Samuel Danishefsky's bioorganic lab at Memorial Sloan-Kettering Cancer Center is a model for chemical research.

SUGAR CONNECTION

Carbohydrate ligands play a role in antibody production and bacterial migration.

WOMEN IN CHEMISTRY

UC Berkeley's Carolyn Bertozzi uses her organic chemistry training to unravel biological problems.

CARBOHYDRATE VACCINES

Researchers accelerate process for automated synthesis of oligosaccharides for medical applications.

January 7, 2002

SCIENCE/TECHNOLOGY CONCENTRATES

MONELL CHEMICAL SENSES CENTER

Institute is devoted to multidisciplinary chemosensory research.

NET-WORK

Filtering tools may make ever-increasing number of online science information resources more manageable.

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