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Donald E. Ingber

George M. Whitesides

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July 2, 2001
Volume 79, Number 27
CENEAR 79 27 p.5
ISSN 0009-2347
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Special Delivery For Small Molecules


A microfluidics technique allows researchers to deliver certain kinds of molecules selectively into regions of a living cell. The work is a collaboration between the groups of Donald E. Ingber, professor of pathology at Harvard Medical School, and Harvard chemistry professor George M. Whitesides [Nature, 411, 1016 (2001)]. Using a technique developed previously, the researchers produce parallel and adjacent streams of different fluids that flow laminarly and mix only slowly by diffusion. If the streams contain membrane-permeable molecules, they will flow right through a cell placed in their path, thereby delivering one type of molecule to one part of the cell and another type to another part. In the experiment shown here (left), a red dye stains mitochondria in the upper half of a bovine capillary endothelial cell, while a green dye stains mitochondria in the lower half of the same cell. The entire cell is also treated with a DNA-staining dye that makes the nucleus blue. Two-and-a-half hours later (right), the mingled colors trace how the two populations of mitochondria have been moving and intermixing inside the cell.

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