—Chiral Counterion Enables Asymmetric C–C Coupling “Reaction joins alcohols and butadiene to form chiral compounds in high yield” A ruthenium catalyst equipped with a chiral phosphate counterion promotes stereoselective C–C coupling of alcohols and aldehydes to butadiene, providing a direct route for converting basic feedstocks to chiral building blocks, report chemists from the University of Texas, Austin (Science, DOI: 10.1126/science.1219274).
by Jyllian Kemsley | March 26, 2012
—An Alkene Carboamination “Organic Synthesis: Rhodium-catalyzed reaction stereospecifically forms a C–C bond and a C–N bond across a C=C bond” Looking to turn simple alkenes into more complex molecules, chemists at Colorado State University report a stereospecific carboamination of C=C bonds. The reaction provides a new way to synthesize functionalized amines, which are often components of biologically important molecules. The rhodium-catalyzed reaction (example shown), developed by Tomislav Rovis and Tiffany Piou, adds a C–C bond and a C–N bond across an alkene’s double bond (Nature 2015, DOI: 10.1038/nature15691). Enoxyphthalimides serve as both the carbon and the nitrogen source in the intermolecular transformation.
by Bethany Halford | October 26, 2015
BUSINESS BUSINESS July 17, 2000 Volume 78, Number 29 CENEAR 78 29 p. 21 ISSN 0009-2347 Wide range of chemicals can be purchased online Site name http://www.website Chemical offerings E-commerce approachesa BulkDrugs.com bulkdrugs.com Drug intermediates A CeerChem ceerchem.com Various E ChemACX (includes ChemSell, ChemQuote) chemacx.com Fine, intermediate, laboratory C CheMatch chematch.com Commodities AE ChemB2B chemb2b.com Fine, custom AC ChemBid chembid.com Various A ChemChain chemchain.com Fertilizers, pest control E ChemConnect chemconnect.com Commodities, specialty AE ChemCross chemcross.com Petrochemicals E Chemdex chemdex.com Lab and research C Chem-eTrade chem-etrade.com Specialty, research, drug intermediates AC ChemFinet chemfinet.com Custom EC Chemical.net chemical.net Lab, environmental C ChemicalBid chemicalbid.com Industrial, agricultural A ChemicalDesk chemicaldesk.com Paper, water treatment E ChemNavigator chemnavigator.com Combinatorial C ChemNet chemnet.com Fine, intermediates C Chempoint chempoint.com Fine, specialty C Chem-Trade chem-trade.com Various E ChemUnity chemunity.com Commodities E Cheop cheop.com Commodities EC Covalex covalex.com Basic AEC Site name http://www.website Chemical offerings E-commerce approachesa e-Chem e-chem.com Various E e-Chemicals e-chemicals.com Various C Efodia efodia.com Specialty C Ethical Auctions ethicalauctions.com Fine A 1st Chemical Market 1st-chemical-market.com Commodities, specialty C fobchemicals fobchemicals.com Research to commodities C Freemarkets freemarkets.com Specialties, commodities A GE Polymerland gepolymerland.com Plastics C getPlastic getplastic.com Plastics C Internet Apex intapex.com Petrochemicals C i2ichemicals i2ichemicals.com Industrial AE PlasticsNet plasticsnet.com Plastics AC Plastics Platform plasticsplatform.com Plastics A PolymerSite polymersite.com Plastics E Powerfarm powerfarm.com Agrochemicals C SciQuest sciquest.com Laboratory, research C Sequencia sequencia.com Custom E Sesami.net/ChemX sesami.net; chemx.com Various AC VerticalNet verticalnet.com Research, industrial, adhesives and sealants C Webalog webalog.com Laboratory C XSAg xsag.com Agricultural C Note: Sites may have limited content. a A = auction, E = exchange/marketplace,C = catalog/procurement.
July 17, 2000
—Multi C–H Functionalizations “Organic Chemistry: Four C–H functionalization reactions in a row promote total synthesis of the natural product (–)-incarviatone A” Developing C–H functionalization reactions is a major focus of organic chemistry research. But using different C–H functionalizations sequentially to streamline complex syntheses remains challenging.
by Stu Borman | September 28, 2015
—Surprise Methyl C–H Activation In DMF “Caltech researchers find that a methyl C–H bond in dimethylformamide can be preferentially activated over the labile aldehyde C–H bond” In a synthetic first, California Institute of Technology's Valerie J. Scott, John E. Bercaw, Jay A. Labinger, and coworkers have found that one of the methyl C–H bonds in dimethylformamide (DMF) can be preferentially activated by iridium over the labile aldehyde C–H bond (Organometallics, DOI: 10.1021/om9002413).
by Stephen K. Ritter | June 15, 2009
—Vitamin C As A Cancer Fighter “When combined with chemotherapy drugs, the essential nutrient improves the outcome for advanced ovarian cancer patients” In the late 1970s and again in the mid-1980s, the Mayo Clinic reported that high oral doses of vitamin C provided no benefit to patients with various types of advanced cancer.
by Lauren K. Wolf | February 10, 2014
—The Lighter Side Of C&EN “” C &EN is, by any measure, a serious magazine devoted to covering a serious topic. C&EN Online, the electronic extension of C&EN, is a complement to and reflection of the print edition of the magazine. C&EN's 55 full-time staff members are deeply committed to providing our readers each week with a package of information essential to them as chemical professionals.
by Rudy M. Baum | August 09, 2004
—C–H bond breakers seek smarter tools “Chemists want to selectively take apart any C–H bond in an organic molecule and install something new. How can they expand their C–H activation toolboxes?” In graduate school, John F. Hartwig decided to study something that many at the time thought was a solved problem.
by Leigh Krietsch Boerner | February 23, 2021
—Onward to simpler C–H functionalizations “Chemists develop a new class of copper catalyst for aromatic imidations and a simple selectivity rule to predict product outcome” Selective C–H activation and functionalization has emerged as an integral strategy for organic synthesis. Chemists have already developed an abundant set of methods, and many researchers are now turning to finding ways of simplifying those strategies.
by Stephen K. Ritter | November 07, 2016
—C&EN Archives “” Three years ago, I decided to write an editorial on a controversy that was swirling around plans to celebrate the centennial of Rachel Carson’s birth (C&EN, June 4, 2007, page 5). I knew from C&EN lore that the magazine had published a highly critical review of Carson’s seminal book “Silent Spring” entitled “Silence, Miss Carson.”
by Rudy Baum | November 08, 2010