The one-pot method mediated by a chiral secondary amine catalyst and base cocatalyst proceeds in 65% yield and better than 98% enantiomeric excess. The team subsequently used the intermediate to prepare (+)-trans-dihydrolycoricidine in a record-low eight steps. The new strategy should provide researchers quicker access to aminocyclitols, McNulty says, which his group is actively pursuing. /articles/92/i27/Short-Synthesis-Wildflower-Alkaloid.html 20140707 Organocatalytic Michael addition-aldol reaction sequence provides a key intermediate and total synthesis of an anticancer prospect Concentrates 92 27 /magazine/92/09227.html /departments/.html /collections/con.html Short Synthesis Of A Wildflower Alkaloid amaryllidaceae, total synthesis, anticancer drug, natural product con Science & Technology Stephen K.
by Stephen K. Ritter |
July 07, 2014