—Better Route To Hard-To-Get Isomers “Peptidic catalyst yields access to chiral biaryl compounds” A new synthetic path to atropisomers—a class of chiral compounds that includes drugs, natural products, and ligands for asymmetric catalysis—could open the door to creating a wider range of such compounds, which until now have been difficult to synthesize. Atropisomers are stereoisomers that can be enantiomeric, owing to a steric barrier to rotation about a single bond. Examples include biaryl compounds with bulky substituents, natural products such as the antibiotic vancomycin, and BINAP, a ligand widely used as a catalyst in asymmetric synthesis. Previous techniques for creating atropisomers relied on capturing them with selective reactions of rapidly equilibrating compounds or forging new bonds between biaryl fragments.
by Stu Borman |
June 21, 2010