—Taking a wider look at tau modifications “Semisynthesis aids study of posttranslational modifications to key Alzheimer’s protein” In the body, tau protein regulates nerve cell growth, nerve signal transmission, and the function of cytoskeletal components called microtubules. But it can also misfold, ending up in aggregates called neurofibrillary tangles in the brains of Alzheimer’s disease patients, making tau a diagnostic and therapeutic target. Cells modify tau extensively by adding a range of extra chemical groups, called posttranslational modifications (PTMs), to the protein. But studies of these modifications up to now have focused primarily on one type of PTM—phosphorylation—in one part of tau—its C-terminal region. So tau’s PTM code, how the modifications affect tau’s behavior and aggregation potential, is mostly unknown.
by Stu Borman |
May 14, 2018