—Faster Route To Prostaglandins “Organic Synthesis: Shortened synthetic sequence could lead to less expensive drugs, novel analogs” A seven-step synthesis of prostaglandin PGF2α, the most complex structure in the prostaglandin family, has been reported by chemists at the University of Bristol, in England (Nature, DOI: 10.1038/nature11411). The abbreviated synthetic sequence could cut the cost of making prostaglandin-based drugs and give chemists a new approach for preparing potentially therapeutic prostaglandin analogs. Prostaglandins play a role in numerous biological processes, including sleep, pain, fever, inflammation, menstruation, birth, constriction of blood vessels, and blood clotting.
by Bethany Halford |
August 16, 2012