The gates open when they encounter precise combinations of environmental cues designed to activate them, such as a particular enzyme or reducing agent present selectively in a tumor. The system is modular, so different stimuli-sensitive gates could be installed in the hydrogel to target drugs to different sites in the body. The researchers showed that a hydrogel with a Boolean AND gate delivered the drug doxorubicin to cancer cells in culture only in the presence of both a matrix metalloprotease and a reducing agent. DeForest and coworkers believe that Boolean targeting could be useful in diagnostics and regenerative medicine as well as in drug delivery. /articles/96/i4/Boolean-logic-used-trigger-drug.html 20180122 Chemical gates open to release drugs from hydrogel site-selectively Concentrates 96 4 /magazine/96/09604.html /departments/.html /collections/con.html Boolean logic used to trigger drug delivery Drug delivery, cancer, targeted drug delivery con Science & Technology Stu Borman pharmaceuticals AND gates in hydrogel open only in the presence of both a matrix metalloprotease and a reducing agent, releasing a bound drug such as doxorubicin.
by Stu Borman |
January 22, 2018