—Toward more judicious solvent selection “AstraZeneca unveils an interactive tool that expands the usefulness of solvent selection guides” Scientists at AstraZeneca have taken solvent selection guides to a new level by developing an interactive software tool. Several pharma companies have created tabular guides over the years for their internal use to aid scientists in considering safety, human health, environmental impact, and regulatory concerns when choosing a solvent for a process. The ACS Green Chemistry Institute’s Pharmaceutical Roundtable offers a solvent guide based on those efforts on its website and as a mobile app. As AstraZeneca’s Louis J. Diorazio, David R. J. Hose, and Neil K. Adlington point out, the limitation of these guides is that they are static and tend to be prescriptive, focusing on avoiding certain solvents and barely considering the main purpose of a solvent, which is to help facilitate a chemical process (Org.
by Stephen K. Ritter |
February 29, 2016