—One-step method determines reaction products’ yield, enantiomeric excess, and configuration “Technique accelerates evaluation of amine-containing chiral compounds” A new technique makes it much easier and cheaper to determine key characteristics of amine-containing chiral compounds synthesized individually or in parallel. The technique, which measures product yield, enantiomeric excess (ee), and absolute configuration in one step, could find widespread use in organic chemistry laboratories, including in drug discovery. Chemists typically determine product yield by isolating synthesized compounds and weighing them. They generally measure ee by analyzing reaction products with chiral high-performance liquid chromatography and absolute configuration by using nuclear magnetic resonance spectroscopy or X-ray crystallography.
by Stu Borman |
October 19, 2016