So began Zasloff’s 2-decade obsession with squalamine. The molecule’s polyamine tail gives it a positive charge. Over the years, he and his colleagues determined that when squalamine enters cells, it binds to negatively charged phospholipid membranes, displacing almost any positively charged protein that is electrostatically bound there.
by Michael McCoy | July 01, 2022
It will also continue to own the non-CGRP drugs in its development pipeline, including troriluzole, which is in Phase 3 trials for obsessive-compulsive disorder, and verdiperstat, in Phase 3 trials as a treatment for amyotrophic lateral sclerosis. /pharmaceuticals/Pfizer-buy-Biohaven-11-6-billion/100/i17 20220512 Deal centers on a potential blockbuster drug for migraine Concentrates 100 17 /magazine/100/10017.html Pfizer to buy Biohaven for $11.6 billion Pharmaceuticals, mergers & aquisitions, migraine, Pfizer, small molecule con bus Rick Mullin pharmaceuticals business mergers-&-acquisitions The structure of riimegepant.
by Rick Mullin | May 12, 2022
Dagostino attributes the shift—from disinfection obsession to balanced cleaning—to increased consumer education. To fight SARS-CoV-2, the virus that causes COVID-19, most surfaces don’t need constant disinfection as much as they need regular cleaning, he says. And even the need for surface cleaning isn’t as strong as it was once thought to be.
by Craig Bettenhausen | January 24, 2022
Yet more than once, I rushed through a critical decision only to find myself stuck obsessing over the options for something unimportant. How do we navigate decisions? I’ve found that white-water rafting offers a helpful analogy. When rafting, you’re confronted with rapids and other obstacles, and you must choose a path through them.
by Jen Heemstra, special to C&EN | December 05, 2021
Roche’s Poehling says that an “obsession” with fixing point mutations “might hold people back from really seeing the true potential of the technology.” Roche and Shape want to use RNA editing to selectively disrupt the interactions between two proteins, something that is difficult for conventional small molecules to do.
by Ryan Cross | October 23, 2021
These two views create a disconnect, and it’s one that is exacerbated by our body image–obsessed culture, says Sarah Nutter, a weight stigma and body image researcher at the University of Victoria. She agrees that weight is not a good proxy for health and is frustrated by the number of researchers and doctors who tell their patients that losing weight will alleviate other metabolic diseases.
by Megha Satyanarayana | October 17, 2021
Alexis: At the turn of the century Swedish natural historians were obsessed with cataloging and categorizing nature. Abney: Practicality is absolutely a stereotype of the Swedish character and as a scientific community, they absolutely went very very deep over a very long period of time in, in attacking this question. Lisa: And mineralogists were also obsessed with the idea of chemically analyzing every new rock they found on the ground. So they separated out rare earth elements, and began to organize them. The first rare earth they identified would eventually be named yttrium, the second, cerium. Alexis: Then lanthanum, didymium—which, oops, turned out to be a mixture of praseodymium and neodymium.
by Kerri Jansen | July 31, 2021
So I became a little obsessed with what’s in these colognes. Some advertise having androstenol and androstenone, which is a legit wild-boar pheromone. So I suddenly came up with the idea of buying one of these pheromone colognes on the internet and testing it by seeing if it would attract a wild boar.
by Megha Satyanarayana | July 14, 2021
Three drug candidates designed with Exscientia AI are in clinical trials, including a therapy for obsessive-compulsive disorder developed with Sumitomo Dainippon Pharma. Insilico’s funding was led by Warburg Pincus with participation from 25 other investors, a majority of them based in China. Insilico says it will use the proceeds to progress its pipeline of 16 therapeutic programs and to initiate new programs.
by Rick Mullin | June 26, 2021