“The hope was that the original PNAs would take us all the way, but I think it’s fair to say that some more chemistry needed to be done,” Appella says. The first generation of PNAs was not soluble in water, so the molecules had an unfortunate tendency to clump up in solution and bind nonspecifically with other biopolymers in cells, leading to toxicity.
by Rachel Brazil, special to C&EN | March 28, 2023
We used a transgenic mouse host and donor model, where topaz (green) reported host collagen production, and cyan (blue) reported donor collagen production. So we have blue bone marrow–derived donor stem cells that are seeded onto these matrices with low-crystalline hydroxyapatite. And this is a slide (shown) of our micro-nanofiber-ceramic stem cell matrix.
by Cato T. Laurencin, 2023 Priestley Medalist | March 26, 2023
The campaign aims to advance chemistry innovations to address the challenges articulated in the United Nations sustainable development goals. The Early Career Postdoctoral–Faculty Bridge Grants are for new faculty members at PhD-granting institutions. Funds can be used by the new faculty member to support a postdoctoral scholar for 2 years to help develop a sustainability-focused research program.
by Christiana Briddell, ACS staff | March 25, 2023
—Pharmaceutical Roundtable research grants available “ ” The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable (GCIPR) is seeking to fund research to advance green chemistry solutions to key pharmaceutical process development and production challenges.The grant topics are addressing sustainable peptide process manufacturing, greener oligonucleotide synthesis, and overcoming practical and engineering barriers to the application of photochemistry or electrochemistry in flow. Four $80,000 grants are available.Additionally, the roundtable seeks to fund four Ignition Grants to support novel chemistry and engineering research directions that address sustainability issues in the pharmaceutical and allied industries (at any stage from drug discovery through manufacturing). Four $40,000 grants are available.Global higher education institutions are invited to submit proposals by 5 p.m.
by Christiana Briddell, ACS staff | March 25, 2023
/biological-chemistry/Scientists-sniff-structure-human-olfactory/101/i10 20230323 The research gives a first look at how chemicals trigger our sense of smell Concentrates 101 10 /magazine/101/10110.html Scientists sniff out the structure of a human olfactory receptor biological chemistry, gpcr, smell, olfactory con scitech Shi En Kim biological-chemistry analytical-chemistry structural-biology ,,,,,, Researchers have solved the 3D structure of the human odorant receptor OR51E2 (green).
by Shi En Kim | March 23, 2023
Green, who studies mechanisms of cell death at St. Jude Children’s Research Hospital, writes in an email. “Arsenite in combination with interferon as a cancer treatment promotes anti-cancer immunity, and necroptosis is known to be very good at promoting such immunity. The findings in this paper may help to understand this and point the way towards predicting the efficacy of such treatment.” /biological-chemistry/biochemistry/Arsenite-induced-necroptosis-requires-stress/101/i10 20230322 Process also depends on proteins that localize in stress granules Concentrates 101 10 /magazine/101/10110.html Arsenite-induced necroptosis requires stress granules biochemistry, cancer, neuroscience, arsenite, necroptosis, oxidative stress, pollutant, ZBP1, RIPK3, alzheimer's con scitech Celia Henry Arnaud, special to C&EN biological-chemistry biochemistry biological-chemistry cancer biological-chemistry neuroscience Fluorescence images with antibodies targeting ZBP1 (green) and RIPK3 (red) show that the proteins colocalize in stress granules.
by Celia Henry Arnaud, special to C&EN | March 22, 2023
/business/biobased-chemicals/US-aims-close-fermentation-capacity/101/i9 20230312 The country is a leader in developing biotech routes to chemicals, but it lacks facilities to make them Stories 101 9 /magazine/101/10109.html The US aims to close its fermentation capacity gap biobased chemicals, business, investment bus Matt Blois business biobased-chemicals environment green-chemistry ,,,,,, Fermworx is adding fermentation tanks at its facility in Georgia to meet the needs of biobased chemical companies clamoring for more contract fermentation capacity in the US.
by Matt Blois | March 12, 2023