—Amphotericin B improves cystic fibrosis symptoms in cultured cells and pigs “Antifungal drug forms ion channels in cells to increase secretion of bicarbonate” An antifungal small molecule drug could restore some of the function lost in cystic fibrosis. Cystic fibrosis is a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an ion channel that transports chloride, bicarbonate, and other anions across the membranes of epithelial cells lining lung airways. When the CFTR ion channel doesn’t work, it adversely affects the pH and viscosity of the liquid lining the airway surface and reduces an individual’s defenses against microorganisms. Martin D. Burke of the University of Illinois at Urbana–Champaign and coworkers added the drug, amphotericin B, to cultured epithelial cells from people with cystic fibrosis.
by Celia Henry Arnaud |
March 13, 2019