—Foghorn Therapeutics takes aim at chromatin hijackers to stop cancer “The start-up, cofounded by Cigall Kadoch, is drugging a molecular machine called BAF, part of the chromatin regulatory system” A decade ago, when Cigall Kadoch joined Gerald Crabtree’s lab at Stanford University, she was an odd fit: the incoming graduate student was determined to do cancer research, but at the time, Crabtree’s group was squarely focused on the brain. Crabtree’s lab was probing the role that intricate molecular machines called chromatin-remodeling complexes played in the developing brain. DNA is tightly coiled inside cells until chromatin-remodeling complexes unpack a stretch of code to make it available for reading. More specifically, DNA is wrapped around balls of proteins called histones, and chromatin-remodeling complexes can add, remove, or exchange these histone cores and even slide them along the DNA strand to help turn genes on at the right time.
by Ryan Cross |
May 12, 2019