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Modern Drug Discovery


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Table of Contents

January-February 1999
Volume 2, Number 1


  The price of a pill
Finding the correct pricing stategy is a complex, high-stakes puzzle for drug companies. Even war games have been found helpful in deciding how much a new medicine should cost.
Crispin Littlehales
  Russian jailhouse genomics: Enlisting a genome to fight MDR tuberculosis
Jim Kling
The genomic DNA sequence of Mycobacterium tuberculosis brings a new drug discovery tool to the fight against multiple drug resistant tuberculosis.
  Rational drug design: Controlling the size of the haystack
Donald B. Boyd
Combinatorial chemistry creates larger and larger haystacks in which to find the needle. Rational design attempts to focus the design process on the smallest possible set of viable compounds.
  Taming the monster haystack: The challenge of compound management
Randy Wedin
There's nothing glamorous about software that keeps track of library compounds. But whether you build it or buy it, it's essential for success with high-throughput technologies.
  E pluribus product
Robert A. Lipper
How can we optimize selection of drug development candidates from many compounds at the discovery stage?


  In Brief
  • Tomato and potato steroids inhibit anesthetics metabolism
  • Trichomoniasis opens door for HIV infection
  • A once-every-three-months drug for multiple sclerosis
  • Studying bone growth in space
  • Using bacteria to put the brakes on cancer
  • Government may fund human stem cell research
  • To your health
Getting past the politics and paperwork of pediatric drug studies
  • The PHARM Game: Drug Discovery and Development
  • Viruses, Plagues, and History
  New Products
  Ad Index