||Combinatorial biosynthesis: Panning for
John K. Borchardt
Genetic engineering may keep one of the richest drug gold
mines from being played out.
||The mysterious placebo effect
Understanding it can help avoid flawed study designs.
||The liposome maker's art: Wrapping toxic drugs in lipid disguises
Researchers turn amphoterrible into Amphotec and
doxorubicin into Doxil.
||Through the looking glass in chiral drug development
Focusing on one stereoisomer may increase efficacy, reduce
side effects, or even extend patent protection.
||Content and discontent: A combinatorial chemistry status report
Richard K. Brown
The new technology has put drug candidates into clinical
trials, but it still hasn't won full acceptance by
||High-throughput characterization of combinatorial libraries
James N. Kyranos and Joseph C. Hogan, Jr.
Generating and interpreting a large amount of analytical
data are necessary to take advantage of combichem's