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Nov/Dec 2000
Vol. 3, No. 9, pp. 83, 85.

new product notes
...Disposable filters. These items have been enlarged with a hydrophilic membrane and feature very low adsorption. They are used for the filtration of highly viscous solutions or solutions with high loads of particulate matter.
Macherey-Nagel 150

Safety cabinet. This biological unit is used to transfer animals. It has an ergonomic design and provides protection for personnel, animals, and the environment. This Class II, Type A/B3 cabinet provides safety and project flexibility.
Baker Company 151

Online shopping. This site offers a wide selection of liquid chromatography supplies, including HPLC columns, guards, and accessories in various phases, lengths, and inside diameters. The online store is located at Keystone’s home site, www.keystonescientific.com.
Keystone Scientific 152

Compact benchtop unit. The IC20 operates as a dry bath, water bath, incubator, refrigerator, or freezer at your workstation. The unit can freeze, chill, or heat samples from –10 to 100 °C in assay plates, centrifuge tubes of all sizes, vials, and test tubes. It has a digital display and control of temperature to 1 °C. The unit also has a countdown timer in days, hours, minutes, and seconds to 30 days.
Torrey Pines Scientific 153

Toxicology screening. This system can be used to analyze biological fluids such as blood, urine, and bile, as well as tissue extracts and stomach contents. It can detect more than 600 drugs and their associated metabolites. By using drug markers to produce an almost linear retention index scale, the system employs a chromatographic technique for toxicological drug screening.
Dionex 154...

Specimen observation. These differential interference contrast (DIC) systems are designed to be used with BX2 series microscopes. They allow optimum imaging of all specimens, including thick and thin cells at high and low magnification. DIC systems are used with polarizing filters and prisms.
Olympus Optical 155

Personal synthesizer. This versatile tabletop organic instrument is ideal for process ...development, lead generation, and lead optimization. It provides operating simplicity for parallel solid- and solution-phase synthesis, with multiple heat zones from –78 to 150 C and gentle, variable-speed vortex mixing. Chemists can work in scales of 1–60 mL, with up to 24 simultaneous reactors under inert conditions. A wide variety of Teflon reactors and standard laboratory glassware can be used. Also available are a digitally controlled, single heat-and-cool module; a direct-cleavage module; and an evaporation module.
Advanced ChemTech 156

...Chemical process pump. The Vogel ICB close-coupled series are an extension to the IC series ISO 5199 frame-mounted chemical pumps. These pumps are compact, economical, and ideal for OEM applications and confined spaces in industrial processes. The ICB range includes 25 pump sizes, with flows up to 450 m3/h (1980 gpm) and heads up to 150 m (492 ft). The pumps are suitable for service temperatures ranging from –40 to 140 C (–40 to 284 F) and operating pressures up to 16 bar (230 psi). ICB pumps can be mounted to any standard IEC motor. No spacer coupling or alignment is required, reducing capital equipment costs and simplifying installation and maintenance.
ITT-Goulds Pumps 157

...Software. ActiveRobot provides customers with full PC-based control of CRS robot systems used in life sciences laboratory automation, quality assurance, and advanced manufacturing applications. ActiveRobot is designed to work with many third-party software development environments and can run up to 10 CRS robots from one PC. Its advantages in biotechnology and pharmaceutical research applications include reduction of development costs, integration with other critical applications, easier debugging, better debugging aids, and increased data management capabilities. ActiveRobot is particularly useful in adding a CRS robot to laboratory workstations to enhance efficiency and speed up sample processing.
CRS Robotics Corporation 158

Biotechnology glossary. The site www.biotechterms.org is a fully searchable version of Technomic’s Glossary of Biotechnology Terms, 2nd ed., by Kimball R. Nill. The glossary is designed for anyone with an interest in biotechnology, including executives who deal with the biotechnology industry—particularly those who may not be formally trained in biotechnology. Clear, concise definitions are provided for quick reference. A unique feature of the online glossary is a reference chain that allows visitors, after finding a term’s definition, to immediately identify and find other definitions of related terms.
Technomic Publishing Company 159

...Analysis system. The AlphaImager 3300 is designed to quickly analyze, document, and archive gels, films, membranes, and plates. The system delivers real-time display, 12-bit (0–3.0 o.d. dynamic range) and Megapixel resolution technology. Using a scientific grade 12-bit Megapixel CCD camera, the AlphaImager 3300 generates more vibrant details and image quality than 8-bit, standard-resolution gel documentation systems.
Alpha Innotech 160

DNA polymerase. Bio-X-Act handles various problems encountered when trying to amplify DNA for which standard polymerase is not sufficient. The system provides primer extension over long regions by reducing premature strand termination and template degradation. It also provides high yield and specificity, even with “dirty” DNA or difficult templates. In addition to 5¢–3¢ DNA polymerase activity, Bio-X-Act possesses 3¢–5¢ proofreading activity, which prevents misincorporations during primer extension. This combination of properties allows Bio-X-Act to give sevenfold higher fidelity than standard polymerase.
Midwest Scientific 161

...Software. Pipeline Pilot is a software package for drug discovery informatics that enables pharmaceutical and biotechnology scientists to derive maximum value from research data. It uses the new approach of data pipelining to process data collections through linked computational steps at extremely high throughput. With Pipeline Pilot, researchers can analyze and mine entire data sets without the limitations of their existing informatics infrastructure. By guiding the flow of data through a protocol of computational components, disparate data sets can be merged, analyzed, or manipulated with complete flexibility.
SciTegic 162

Mass plate storage. This tool stores large numbers of microplates for targeted and ultrahigh-throughput screening. The automated plate storage and retrieval system—Mega-Stor—presents compound daughter plates to a robotic platform, stacker system, or cherry picker and can dramatically improve laboratory work flow. The unit is a freestanding vertical cylinder with dual carousels. Mega-Stor operates as a storage unit at temperatures from 25 C (ambient) to –20 C. The dual carousels consist of 25 columns of microplate holding shelves, which can be configured to hold deep-well plates, half-height plates, or standard microplates. The user can change the configuration to hold up to 1675 standard microplates, 1080 half-height plates, or 850 deep-well plates.
Tomtec 163

Glovebox. The 870 Closed Loop Containment Isolator is completely automated and has negative pressure. If the internal negative pressure rises above –0.55 in. H2O, the programmable logic controller opens the atmosphere supply valve. Incoming gas is automatically filtered through dual HEPA filters. When the internal atmosphere reaches the point set by the user, the automatic valve closes. The unit also features a manual ball valve for connection to an exhaust/filter system.
Plas-Labs 164

Antibodies and antigens. These compounds are useful in various neuroscience applications, such as immunohistochemistry, immunoassays, immunofluorescence, immunocytochemistry, and Western blot. Monoclonal antibodies have been developed specifically for astrocytes, dopamine, G0 protein, MAP-2, phodopsin, S-100, synaptophysin, syntaxin, and tau.
Biodesign 165

Assay. This protein conjugate screening column allows drug protein conjugate isolation in about 20 s for fast combinatorial library screening. It requires less than 10 nmole of protein for detection and is recommended whenever sample protein is limited. With an exclusion limit of 600 Da, small solutes can be quickly separated by size from the s conjugate without affecting even weak binding constants. Columns can be coupled directly to reverse-phase columns for LC/MS detection to fully automate the technique.
The Nest Group 166

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