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  Focus: Pharmaceuticals January 2004
  The Chemistry of ADMET   The Chemistry of ADMET (262 KB PDF)
How a compound behaves in the body is a result of its unique chemistry. Modeling the relationship between structure and function is critical to drug development.
Mark S. Lesney
  The Chemistry of ADMET  

Crystallography on Drugs (233 KB PDF)
High-throughput methods for obtaining protein crystal structures are providing chemists with “blueprints” for drug design.
David Filmore


Update (99 KB PDF)
Research News and Science Bits

Systems & Data Handling
Seek and Ye May (Not) Find
(62 KB PDF)
Finding information online can require specialized searches and subtle tricks.
Mark S. Lesney

Instruments & Applications
Monitoring Metabolism
(75 KB PDF)
Advances in NMR technology have made metabonomic research possible.
Werner Maas


Technology & Tools
The MAOS That Roared
(68 KB PDF)
Microwave-assisted organic synthesis is making inroads from combichem to peptide synthesis.
Randall C. Willis


Business Matters (52 KB PDF)
Marketplace, Deals, and People


Industry Facts & Figures
Biotechnology Separations
(44 KB PDF)
Separation technology is engineering for the life sciences.
Kimberly S. Cleaves

General Interest  

For Openers
New and Improved
(36 KB PDF)
James F. Ryan

Chemistry Chronicles
An Aging Question
(61 KB PDF)
The discovery of radioactive decay was pivotal to scientifically determining the age of the Earth.
David Filmore

Chemist's Bookshelf (64 KB PDF)
 • Protecting America’s Health
   Reviewed by Randall C. Willis

 • Introduction to Macromolecular Crystallography
   Reviewed by Timothy C. Umland


Health Perspectives
September Salves
(60 KB PDF)
As bodies grow older, reactions to common diseases and drugs alter dramatically.
Mark S. Lesney

LabAutomation 2004
(50 KB PDF)
The annual automation show heads north to a new California home.

Crossword Puzzle
(23 KB PDF) || Solution (html)
Marge Deibel

Lighter Elements (72 KB PDF)
Humorous tales from readers and other sources . . . plus a cartoon.


Product Review
Liquid Handling: Dispensing Reliability
(64 KB PDF)
Systems for pipetting small volumes to and from multiwell plates are improving.
Michael J. Felton


Product Profile
Membrane Filtration
(68 KB PDF)
From pharma to materials science, membranes facilitate sample prep.
Felicia M. Willis

Product Information (html)
New products, literature, and websites.

ISSN 1532-4494