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Table of Contents

Volume 85, Number 9: February 26, 2007

Cover Story

Biopharma

Hsp90, a molecular chaperone protein, has come into its own as a target for cancer therapies.

COVER: Kosan's second-generation inhibitor of the protein Hsp90 is firmly anchored in the pocket created by a portion of Hsp90 and ATP. Kosan Biosciences

Cover Image

News of the Week

Halogen-Induced Cyclization

Long-sought enantioselective reaction leads to halogenated steroidal compounds.

Shire Acquires New River

Shire buys partner to have ADHD drug all to itself.

Detecting Nuclear Materials

Two agencies unite to spur academic research in breakthrough technologies.

Molecular Close-Up

Images show motions of single, confined molecule.

F. Albert Cotton Dies

Inorganic chemistry pioneer was first to show existence of metal-metal quadruple bond.

Rail Strike Hits Canadian Firms

Chemical company executives call on Canadian government to act.

Largest Chemically Made Protein

HIV protease analog assembled using kinetic ligation approach.

Columbus' Silver Mining Debunked

Chemistry rewrites history of precious-metal processing in New World.

Environmental Justice

Hazardous waste facilities are often sited in poor, minority areas, study shows.

Business

Business Concentrates

Brushing Up On Plant Riches

Phytochemicals get boost from advanced chemical analysis, synthesis.

Chemical Earnings Show Strong Rise

But year-to-year fourth-quarter performance masks slowing of growth as 2006 ended.

Pharma Takes Action

Restructuring in the face of disappointing financial results obscures improving pipelines.

Biotech Milestones

Product successes in 2006 translate into growing sales and profits for biopharmaceutical firms.

Government & Policy

Government & Policy Concentrates

Industry Adapts To New Congress

Business groups maintain ambitious agenda but face tough battles on Capitol Hill.

Power Struggle

Lawmakers probe Bush directive, fearing decrease in their influence on regulations.

Science & Technology

Science & Technology Concentrates

Quinine Revisited ... Again

Historical research helps untangle the complex mythology of quinine synthesis.

Avoiding Global Collapse

Chemists have a vital role to play in achieving sustainability.

Awards

Call for Nominations for Linus Pauling Award

2007 Midwest Award Nominations

Nominations Sought for Citation for Chemical Breakthroughs

Nominations Wanted For Paul Marks Prize

Ryoji Noyori Prize goes to Evans; 2007 Nominations Sought

Books

Science News As An Object of Study

A seasoned science writer analyzes how news is made.

Editor's Page

First Draft

The Departments

Letters

People

Newscripts

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