Biologic Drugs

Quote of the Week
"Women were not running things when the economy collapsed. Women are now being asked to help put it back together again."
BETTY SPENCE, PRESIDENT, NATIONAL ASSOCIATION FOR FEMALE EXECUTIVES – p. 26
July 20, 2009
In This Issue:
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Highlights

Cover Story
Analyzing Protein Drugs
Scientists devise new, streamlined methods to understand the complexity of biopharmaceuticals. (pp. 20-23)

Business
Women In Industry (Member Content)
Women made some strides at the very top but have little to show elsewhere. (pp. 26-27)

Government & Policy
Extending Plant Security Standards (Member Content)
Chemical industry is fighting efforts to require 'safer' technologies, allow lawsuits. (pp. 33-35)
Table of Contents
News Of The Week
Academic Chemists Cement Global Ties p. 14
Leaders of U.S., Chinese chemistry departments meet in Beijing to share experiences.
Exxon Invests In Algal Biofuels p. 15
Project represents a new direction for oil giant.
RNA Distraction Is Therapeutic p. 15
Antisense nucleotides could one day combat a form of muscular dystrophy.
Preparing For Swine Flu p. 16
Vaccine procurement ramps up as virus gains ground.
A New Molecular Dynamic Frontier p. 16
New experiments show bond excitation can lead to counterintuitive products.
Pesticide Controversy p. 17
Activists express concern over field-test request for sulfuryl fluoride because of its global-warming potential.
LyondellBasell Under Fire p. 17
Bankrupt firm's plan to close facilities in Texas has neighbors in an uproar.
DNA Sorts Carbon Nanotubes p. 18
Specific sequences separate nanotubes according to chirality.
Judging Doctoral Programs p. 18
With methodology in place, long-awaited graduate program rankings may soon be released.
Business

Women In Industry pp. 26-27 (Member Content)
Women made some strides at the very top but have little to show elsewhere.
Can Conundrum pp. 28-29 (Member Content)
Chemists come up short in attempts to remove bisphenol A from food can liners.
The End Of An Era p. 30 (Member Content)
Glyphosate, the herbicide behind Monsanto’s success, takes a back seat at the firm.
Business Concentrates pp. 24-25 (Member Content)
- Drug Firms Unveil Infectious-Disease Projects
- Big pharma firms are upping their commitment to medicines for infectious diseases that disproportionately impact developing countries...
- Sipchem, Hanwha Team Up For Saudi Project
- Saudi International Petrochemical (Sipchem) and South Korea's Hanwha Chemical have formed a joint venture that will invest about $1.1 billion in projects in Al-Jubail, Saudi Arabia...
- BASF Puts A Spring In Athletes' Step
- For the Aug. 15 start of the International Association of Athletics Federations' World Championships, Berlin's Olympic stadium is sporting a blue track made with BASF's polyurethanes...
- Altana Will Buy U.S. Ink Maker
- German specialty chemical company Altana has agreed to acquire Water Ink Technologies for an undisclosed sum...
- Explosions Take Lives In China And France
- Five people died last week in an explosion at Luoran, a dyestuff chemicals producer located in Luoyang City in China's Henan province, according to Xinhua, the Chinese state-run news agency...
- U Of Georgia Licenses Curing Technology
- The University of Georgia Research Foundation is licensing a visible-light-based curing technology to adhesives and sealants maker Three Bond International...
- China Approves Saudi Chemical Investment
- China's National Development & Reform Commission has approved Saudi Basic Industries Corp.'s 50% participation in a petrochemical complex that Sinopec is building in Tianjin...
- Chevron Phillips Completes PPS Plant
- Chevron Phillips Chemical has completed a 10,000-metric-ton-per-year polyphenylene sulfide plant at its Borger, Texas, site...
- Praxair Invests In Solar Sector
- Praxair's electronics division has made $15 million in investments to expand its capacity for tubular sputtering targets used by the solar industry for physical vapor deposition of coatings...
- Vertex Will Sell Milestones On Drug
- In an unusual strategy to raise cash, Vertex Pharmaceuticals wants to sell off potential milestone payments associated with the development and commercialization of its lead drug candidate...
- Merck And Portola In Heart Drug Alliance
- Merck & Co. and Portola Pharmaceuticals are working together to develop betrixaban, an oral anticoagulant now in Phase II clinical trials for the prevention of stroke in patients with atrial fibrillation...
- Abbott And GSK Join For Cancer Diagnostic
- Abbott Laboratories and GlaxoSmithKline will develop an automated molecular diagnostic test that uses polymerase chain reaction (PCR) technology to screen non-small-cell lung cancer tumors...
- Japanese Drugmaker to Acquire U.S. Firm
- Japan's Hisamitsu Pharmaceutical has offered to acquire Miami-based Noven Pharmaceuticals for $430 million...
- Business Roundup
- Occidental Chemical is the buyer of Dow Chemical's calcium chloride business, BASF and ReVolt Technology, Huntsman Corp. founder Jon M. Huntsman, Dow Chemical, NatureWorks, LabVantage Solutions, Lonza, Baxter International...
ACS Comment
Elections And The Petition On Election Timelines & Procedures 2009 p. 51 (Member Content)
ACS News
I&EC's Century Of Progress p. 52 (Member Content)
ACS's second journal responded to the changing needs of the chemical enterprise.
Employment
Organic Chemistry Far From The Bench pp. 57-59
Training in the versatile discipline prepares chemists for jobs beyond the lab.
Government & Policy

Extending Plant Security Standards pp. 33-35 (Member Content)
Chemical industry is fighting efforts to require 'safer' technologies, allow lawsuits.
Government & Policy Concentrates p. 32 (Member Content)
- Mercury Reduction At Coal-Fired Plants
- The Government Accountability Office reports that tests run by the Department of Energy and industry show that...
- Senate Moves On Generic Biologics
- The Senate Health, Education, Labor & Pensions (HELP) Committee approved an amendment on July 13...
- Combating Fake Drugs
- FDA has issued draft guidance for industry on the use of physical-chemical identifiers (PCIDs), such as inks, pigments, and flavors...
- U.S., EU To Beef Up Talks On REACH
- The European Union's law on Registration, Evaluation, Authorization & Restriction of Chemical substances...
- Laureates Urge More Climate R&D
- A group of 34 U.S. Nobel Laureates last week called on President Barack Obama and Congress to substantially increase spending...
» more government & policy news...
Books
Tracing Earth History pp. 49-50
An exploration of how fossil molecules can provide valuable clues to geological and biological history.
Awards
Stephen Benkovic Is Franklin Medalist p. 54 (Member Content)
Russell Rouseff Honored For Flavor Chemistry Work p. 54 (Member Content)
Founders’ Award To Stephen Hecht p. 54 (Member Content)
Graduate Students Win Environmental Chemistry Awards p. 54 (Member Content)
Tolman Medal To Joan Valentine p. 54 (Member Content)
Andrew W. Maverick Earns Coates Award p. 54 (Member Content)
Christopher Walsh Receives Scott Medal p. 54 (Member Content)
Science & Technology

Green Chemistry In The Mainstream pp. 39-42 (Member Content)
Cleaner, cheaper, smarter chemistry is no longer a pie-in-the-sky idea.
Extended Family pp. 43-46 (Member Content)
Getting to know the trillions of microbes cohabitating with humanity.
Inside Instrumentation p. 48 (Member Content)
Technology and Business news for the laboratory world.
Science & Technology Concentrates pp. 37-38 (Member Content)
- Finally, Haplophytine
- More than 50 years after its discovery, the complex indole alkaloid with insecticidal properties has yielded to total synthesis.
- Lysine Acetylation Gets A Big Boost
- An in-depth look at lysine-acetylated proteins reveals that the modification regulates more cellular functions than previously thought.
- Microfluidic Device Mimics Golgi Organelle
- Chip with multiple reservoirs for different enzymes functions just like the little-understood cellular component in carrying out glycosylations.
- Fertilizer's Perchlorate Legacy
- Groundwater contaminated with perchlorate (ClO4-) from fertilizer appears to be a consequence of the U.S.'s agricultural history.
- Graphene Lends Microscopy Support
- Berkeley researchers demonstrate the carbon sheet's utility in a novel application: as a specimen support in transmission electron microscopy.
- Unprecedented Iridium(VIII) Seen
- Despite theoretical predictions to the contrary, IrO4 featuring an 8+ iridium center can exist, at least in a low-temperature solid matrix.
- Novel Iridium-Doped Superconductor
- Replacing some iron with iridium in a rare-earth iron arsenide, forming SmFe0.85Ir0.15AsO, yields a new strategy for making superconductors.
- Protein Structure Helps Decipher Route To Selenocysteine
- X-ray structure of selenocysteine's transfer RNA coupled to the SepSecS enzyme provides a better view of selenocysteine biosynthesis.
» more science & technology news...
Editor's Page
Chemistry Challenges p. 5
Stories that focus on issues before the chemistry enterprise and developments in diverse scientific areas...
The Departments
Letters pp. 6-12 (Member Content)
Obituaries pp. 55-56 (Member Content)
Newscripts p. 64
Taking On The Locoweed, Bee Medicine
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