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RNA Interference
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Quote of the Week

"It's time for macrocycles to become more visible in drug discovery. More people should know about the power of this structural class."
MARK L. PETERSON, VICE PRESIDENT OF INTELLECTUAL AND OPERATION, TRANSZYMEp. 54

September 7, 2009

In This Issue:

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October 24, 2011 Issue
October 17, 2011 Issue
October 10, 2011 Issue
October 3, 2011 Issue

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Highlights

Cover Story

RNA Interference

Drug delivery has become a key factor in the competition to make drugs based on nature's gene-silencing pathway. (pp. 18-27)

ACS News

Election Statements

Candidates for ACS president-elect and directors share their views and goals. (pp. 75-88)

Education

Nontraditional Pathways

Back-to-school supplement explores alternatives to the traditional college education experience. (pp. 91-99)

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Table of Contents

News Of The Week

New Approach To A Classic Structure DNA Nanostructures Huntsman To Buy Most Of Tronox Danaher Invests In Mass Spec

New Approach To A Classic Structure p. 12

Organic Chemistry: Oxidative ring-closing reaction boosts yield of key erythromycin precursor.

Khosla Grows Investment Funds p. 13

Cleantech: Venture capitalist has $1 billion to back new technology.

New Bond In Biology p. 13

Biochemistry: Sulfilimine connection toughens tissue.

Crystalline Wiggle Room p. 14

Host-Guest Mystery: Trapped molecules hint that crystals may not be as rigid as presumed.

DNA Nanostructures p. 14

DNA Scaffolds: Scientists attain long-sought goal of 3-D DNA crystals.

Huntsman To Buy Most Of Tronox p. 15

Acquisition: Deal will make Huntsman the world’s second largest maker of titanium dioxide.

Delay In Climate-Change Bill p. 15

Senate bill postponed for later in September.

Dainippon Takes Over Sepracor p. 16

Acquisition: The purchase gives Japanese firm key U.S. presence.

Danaher Invests In Mass Spec p. 16

Instrumentation: $1.1 billion deal brings AB Sciex and more.

Business

Powerful Stuff pp. 32-34 (Member Content)

Materials get attention and funding in effort to create U.S. lithium battery industry .

Up From The Ashes pp. 36-37 (Member Content)

U.S. soda ash industry fights its way out of the recession.

Toray Taps China p. 38 (Member Content)

Japanese firm's plant in Beijing will produce high-technology water purification membranes.

Business Concentrates pp. 29-30 (Member Content)

  • Merck Sets New Structure

  • Merck & Co. has announced a reorganization plan, naming top managers for the five divisions that will be formed following the company’s acquisition of Schering-Plough...
  • Clariant Sells Its Silicones Business
  • Clariant has sold its specialty silicones business to GenNx360 Capital Partners, a private equity firm focused on industrial businesses. GenNx360 has renamed the business SiVance...
  • Bayer Wins Agchem Patent Suit In China
  • Bayer CropScience has won a lawsuit against two Chinese firms that it claims were infringing its patent on mefenpyr, a chemical that improves herbicide selectivity...
  • Invista Boosts Stake In Protective Wear
  • Invista will increase its investment in Ashburn Hill, a South Carolina-based manufacturer of fire-resistant apparel for firefighters and industrial workers...
  • Wyatt Technology Wins On Appeal
  • Instrument maker Wyatt Technology has won its appeal of a lawsuit against Viscotek relating to the theft of Proterion Corp. dynamic light-scattering technology that Wyatt acquired in late 2004...
  • EU Funds study of Nanoparticles
  • The European Union has awarded the University of Ulster’s Biomedical Sciences Institute a grant to investigate the link between nanoparticles and disease...
  • Archimica And Chemic Partner On APIs
  • Archimica and Chemic Laboratories have formed a partnership for the development and commercialization of active pharmaceutical ingredients (APIs)...
  • Roche Takes Option To Buy Lonza Plant
  • Roche has exercised an option to buy Lonza’s cell culture biologic facility in Singapore. The price is $290 million plus milestone payments of $70 million...
  • TC Will Work With Roche And Celgene
  • PTC Therapeutics has signed a research and licensing agreement with Roche for the development of small molecules with PTC’s Gene Expression Modulation by Small-Molecules, or GEMS, technology...
  • Shantha Gets Vaccines Contracts
  • Shantha Biotechnics, part of Sanofi Pasteur, has been awarded $340 million in contracts from the United Nations to supply vaccines between 2010 and 2012...
  • Catalyst Gets Drug From Northwestern
  • Catalyst Pharmaceutical has paid Northwestern University an undisclosed sum for the rights to develop a novel class of GABA aminotransferase inhibitors and derivatives of vigabatrin...
  • Novartis Unveils New Lab Concept
  • Novartis has launched its Lab of the Future initiative to create laboratories with flexible work spaces, modular furniture, and integrated technologies...
  • Trubion, Facet Link For Leukemia Drug
  • Trubion Pharmaceuticals has partnered with Facet Biotech to commercialize TRU-016, a Trubion product in Phase I clinical trials for the treatment of chronic lymphocytic leukemia...
  • Business Roundup
  • Asahi Kasei, Mitsubishi Corp. and Belchim Management, Air Products & Chemicals, BPT, LyondellBasell Industries, TCG Lifesciences, Sanofi-Aventis, Bayer Schering Pharma...

ACS News

Election Statements pp. 75-88

Candidates for ACS president-elect and directors share their views and goals.

Government & Policy

An Inconclusive Record pp. 42-45 (Member Content)

How Sotomayor will act on Supreme Court cases affecting the chemical industry can't be gleaned from her prior rulings.

Risk And Opportunity pp. 46-48 (Member Content)

ACS Meeting News: Department of Homeland Security seeks innovation in antiterrorism technology.

Toxic Reduction p. 50 (Member Content)

Bayer plans to cut methyl isocyanate use, storage after deadly accident and investigations.

Government & Policy Concentrates p. 40 (Member Content)

Education

Nontraditional Pathways p. 91

Back-to-school supplement explores alternatives to the traditional college education experience.

An Enriching Respite pp. 92-94

Gap-year experiences help students recharge, refocus.

Community Colleges pp. 95-96

In a down economy, these educational workhorses are a smart choice.

Learning Chemistry Online pp. 97-99

Despite a slow start, distance-learning of chemistry is gaining ground.

Continuing Education pp. 98-99

ACS online courses offer convenience for the working chemist.

Books

The Age Of Wonder

Never-Ending Controversy pp. 72-74

Finding truth on both sides of the water fluoridation debate.

Science & Technology

Big Hopes Ride On Big Rings pp. 54-57 (Member Content)

ACS Meeting News: Constraining molecules in macrocyclic rings could help address challenges in drug discovery.

Nuclear Medicine's Conundrum pp. 58-64 (Member Content)

Another sudden shortage of technetium-99m calls for long-term solutions.

RNA's Outfits pp. 65-68 (Member Content)

The nucleic acid has dozens of chemical costumes.

Superresolution Imaging Goes 3-D pp. 69-71

ACS Meeting News: New microscopy techniques break the diffraction limit in three dimensions.

Science & Technology Concentrates pp. 52-53 (Member Content)

Editor's Page

Multitaskers—Give It A Rest p. 3

The Departments

Letters pp. 4-11 (Member Content)

Newscripts p. 112

Beetle Chemistry, Walking In Circles

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