Neglected Diseases
Quote of the Week
"If the U.S. abandons its role of leadership in science and technology, there are others who will gladly step into that role."
RALPH L. MCNUTT JR., SPACE SCIENTIST, JOHN HOPKINS APPLIED PHYSICS LAB – p. 47
November 9, 2009
In This Issue:
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Highlights
Cover Story
Partnering For Global Health
Drug companies and nonprofits are taking novel approaches to refill the pipeline of new drugs and vaccines for neglected diseases. (pp. 16-22)
Government & Policy
Politics, Money, And Climate (Member Content)
News Analysis: Copenhagen meeting is unlikely to produce a new climate-change treaty. (pp. 37-39)
Science & Technology
Chemistry Behind The Wall
Twenty years after the fall of the Berlin Wall, chemists who lived in former East Germany reflect on science then and now. (pp. 42-46)
Table of Contents
News Of The Week
Old Drugs, New Tricks p. 11
Polypharmacology: Ligand-based approach finds new targets of known drugs.
Clorox To Stop Using Chlorine p. 12
Plant Security: Bleach maker will end shipment of hazardous chemical.
OSHA Hits BP With Record Fine p. 12
Safety: $87 million penalty for violations, failure to comply with 2005 settlement.
Climate-Change Maneuvers p. 13
Legislation: Democrats push ahead as Republicans boycott markup meetings.
Pharma Strategy p. 13
Novartis makes major R&D and vaccines investments in China.
Light Commands Ion Channel p. 14
Chemical Biology: Photosensitive reaction opens or shuts potassium's flow.
Ironing Out Mercury's Makeup p. 14
Planetary Science: New results from spacecraft flyby show iron-rich surface.
Japanese Earnings Surprise p. 15
Fiscal First Half: Firms performed better than feared.
Environmental Scrutiny p. 15
EPA will assess impacts of black carbon and drilling chemicals for hydraulic fracturing.
Business
Solar On Sale pp. 28-30 (Member Content)
Photovoltaic prices will continue to drop, thanks to an oversupply of polysilicon.
Executive Upgrade pp. 32-33 (Member Content)
Technology management program receives high marks, but not all are pleased.
C&EN Talks With Peter Pollak p. 34 (Member Content)
A visionary in the fine chemicals industry claims a victory in a still-risky business.
Business Concentrates pp. 24-25 (Member Content)
- J&J Revamps, Cuts Jobs
- Johnson & Johnson is restructuring to improve its operating efficiency through more simplified processes and fewer layers of management...
- DuPont Forecasts Strong Growth
- As the global economic recovery gets under way, DuPont CEO Ellen J. Kullman predicts that her firm will deliver 20% compound annual earnings growth...
- Dow Corning Gets Silicon Metal Plants
- Dow Corning has bought one silicon metal plant and acquired an interest in a second one from Globe Specialty Metals in a $175 million deal...
- Germany’s Merck Leads OLED Group
- Merck KGaA is leading a new German consortium that aims to develop soluble materials to be used in large organic light-emitting diodes...
- ExxonMobil, Toray In Battery film Venture
- ExxonMobil Chemical’s Japanese affiliate and Japan’s Toray Industries are forming a 50-50 joint venture to develop and make separator films...
- SGL And BMW Form Carbon Fiber Pact
- The German carbon fiber maker SGL is forming joint ventures with automaker BMW and chemical maker Mitsubishi Rayon to make carbon fiber, the fiber’s precursor, and downstream fabric...
- Mitsui And Sinopec Firm Up China Plans
- Mitsui Chemicals and Sinopec plan to spend about $660 million in China to build new plants and acquire an existing one...
- Lilly Opens Labs In California
- In a move to advance its biotech drug pipeline, Eli Lilly & Co. opened a new biotechnology center in San Diego last week...
- DSM Shelves China Vitamins Project
- DSM has halted talks with North China Pharmaceutical Group about forming a vitamins and anti-infectives joint venture...
- Carbogen Revamps Swiss Operations
- The pharmaceutical chemicals firm Carbogen Amcis plans to restructure its three Swiss facilities in response to a decline in customer products in the early phases of drug development...
- Archimica Makes Changes In Italy
- Pharmaceutical chemical maker Archimica has sold its active pharmaceutical ingredient (API) plant in Isso, Italy, to the Italian firm Erredue...
- Takeda Licenses Amylin Obesity Drugs
- Takeda Pharmaceutical is licensing two obesity drugs in development at Amylin Pharmaceuticals...
- Merck Closes On Schering-Plough
- Merck & Co. completed its $41 billion acquisition of Schering-Plough last week...
- Business Roundup
- Cambrios, Equinox Chemicals, Lubrizol, Nalco, Celanese, China's Ministry of Commerce, GlaxoSmithKline and Pfizer, Biovitrum, Lonza...
Government & Policy
Politics, Money, And Climate pp. 37-39 (Member Content)
News Analysis: Copenhagen meeting is unlikely to produce a new climate-change treaty.
Government & Policy Concentrates p. 36 (Member Content)
- EPA Proceeds With Carbofuran Ban
- EPA is preparing to implement a final rule that will ban carbofuran residues on all foods sold...
- Industry Gets Federal Energy Grants
- Last week, the Department of Energy announced $155 million in industrial grants for 41 industrial energy-efficiency projects...
- Benefits Of Tech Transfer Reported
- The biotechnology industry says a new study provides evidence of the importance of university and industry...
- Early Drywall Tests Not Conclusive
- Studies done by federal agencies trying to pin down the causes and health impacts of reported sulfur emissions from drywall made in China...
- Initiative Spreads Science Around World
- A program announced on Nov. 3 by Secretary of State Hillary Rodham Clinton will deploy prominent scientists to bolster science...
» more government & policy news...
People
Obituaries p. 49 (Member Content)
Science & Technology
Chemistry Behind The Wall pp. 42-46
Twenty years after the fall of the Berlin Wall, chemists who lived in former East Germany reflect on science then and now.
The Last of NASA's Fuel p. 47 (Member Content)
Reluctance to restart production of plutonium-238 could mean the end of deep-space exploration.
Digital Briefs p. 48 (Member Content)
New software and Websites for the Chemical Enterprise.
Science & Technology Concentrates pp. 40-41 (Member Content)
- Enzyme Doubles Up Its Binding
- A German research team reports the first enzyme that can simultaneously bind both enantiomers of a ligand in its active site.
- Electronic Structure Helps Define Palladium Cluster Reactivity
- A link between metal cluster size, electronic properties of the cluster, and catalytic activity could help in designing better, less expensive catalysts.
- Sunscreen Additive’s Allergenic Effects
- A toxicology study sorts out how dibenzoylmethanes used to filter out UV-A light photodegrade into compounds that irritate the skin.
- Metallofullerene Matryoshka
- Cluster atoms in a carbon-scandium-fullerene complex, C2@Sc4@C80-Ih, fit inside one another like the famous Russian nesting dolls.
- Mercury In Fillings Turns To Sulfide
- Fresh dental amalgam is mostly metal, but over time most of the filling surface converts into mercuric sulfide, with possible toxicity effects.
- A Pinch Of Salt Softens Hydrogel
- A “saloplastic” polymer electrolyte complex can be reversibly softened up and processed as a biomaterial by simply adding table salt.
- Molecular Switches Turn On Proenzymes
- Researchers at UCSF find nonnatural small molecules that directly activate enzyme precursors––no protein middleman required.
- Solvent-Free Peptide Synthesis
- French chemists employ a ball-mill grinder to string together amino acids in the first reported solvent-free method for making a peptide bond.
» more science & technology news...
Editor's Page
Medicine And Climate p. 3
The Departments
Letters p. 4-9
Newscripts p. 56
Cardboard Scents, Splatter Science, Bear Break-Ins
This Week Online
C&EN Webinar
C&EN Webinar on R-Group Screening
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Register Free at http://pubs.acs.org/cen/webinar/
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