COVER STORY
February 11, 2002
Volume 80, Number 6
CENEAR 80 6 pp. 29-34
ISSN 0009-2347
IN SITU CLICK CHEMISTRY

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COURTESY OF FLAVIO GRYNSZPAN

TEMPLATED REACTION Generic azide-acetylene reaction in its nontemplated form (inset, top left) produces equal amounts of syn- and anti-isomeric products. But when acetylcholinesterase (blue) was used as a template for the reaction of acetylene (left) and azide (right) building blocks, the syn addition product (structure at upper right and space-filling model in enzyme active site) from the two highlighted azide and acetylene building blocks was the only compound formed. The product turns out to be the strongest noncovalent inhibitor of acetylcholinesterase yet identified.

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