Cover Story  
  August 8, 2005
Volume 83, Number 32
pp. 41-50

Fusion Warren, Danishefsky, and coworkers used chemical ligation to create a bifunctional glycopeptide by combining two glycopeptides, each containing a different carbohydrate. In a preceding step, each of the two glycopeptides was made by adding an oligosaccharide to a peptide immediately before ligation. Asterisks indicate asymmetric centers that cause oligosaccharides to each adopt two different stereochemical forms.
Courtesy of J. David Warren

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