Special Reports

October 24, 2011

Coverstory: Bryostatins Retain Promise

New results in total synthesis reinvigorate a 40-year-old field of research. (pp. 10-17)

October 17, 2011

Coverstory: Emerging Strategies

Faced with change, pharmaceutical firms shift business mix to generics and emerging markets. (pp. 15-20)

Coverstory: Shifting Generics To The Super Side

Some generic drug makers aim to innovate and create differentiated products in a competitive market. (pp. 22-26)

October 10, 2011

Coverstory: Lipids Take Charge

Mass spectrometry propels the field of lipidomics. (pp. 15-20)

October 3, 2011

Coverstory: Bridging The Gap

As big pharma exits early-stage drug development, contract research firms are serving the nonprofit and government institutions that are taking it on. (pp. 14-19)

September 26, 2011

Coverstory: Getting The Steel Out

Automakers push ahead on energy-saving carbon fiber composites despite questions of economic viability. (pp. 10-14)

September 19, 2011

Coverstory: Breaking In The New

Developers of new polymers are trying to avoid the hazards that have made success difficult for many of their predecessors. (p. 14)

September 12, 2011

Coverstory: High School Science

C&EN examines the impact of dedicated teachers and volunteers, as well as revisions to AP chemistry. (p. 47)

Coverstory: Inspiring Students To Achieve

High school chemistry teachers show that the best way to teach is often by example. (pp. 48-50)

Coverstory: Science Coaches

Under the ACS pilot program, members partner with teachers to fortify their curriculum, inspire students. (pp. 51-53)

Coverstory: Renewing Advanced Placement

The College Board is overhauling the AP chemistry curriculum and exam to focus on conceptual understanding. (pp. 54-55)

September 5, 2011

Coverstory: Covalent Drugs Form Long-Lived Ties

Irreversible inhibitors may provide unique benefits in drug development. (pp. 19-26)

August 29, 2011

Coverstory: Retardant Debate

Sparks fly over the environmental effects of fire retardants used by the U.S. Forest Service. (pp. 11-15)

August 22, 2011

Coverstory: Anesthesia's Awakening

Chemistry informs the quest to understand anesthetics and make them better. (pp. 13-20)

August 15, 2011

Coverstory: Examining Biofuels Policy

Government mandates have shaped the market but not always for the best. (pp. 10-15)

August 8, 2011

Coverstory: Instrumental Efforts

Entrepreneurs take big risks to bring the latest scientific tools to market. (pp. 14-19)

August 1, 2011

Coverstory: Taking It Back

Material makers will have to adapt to help consumer goods firms fulfill product stewardship goals. (pp. 12-15)

Coverstory: Don't Toss It!: Resources abound to help consumers and manufacturers enable responsible reuse and recycling

July 25, 2011

Coverstory: Global Top 50

Chemical producers show surprisingly good profits soon after the recession. (pp. 12-15)

July 18, 2011

Coverstory: Testing Gulf Seafood

After the oil spill, analytical protocols to assess contaminants in seafood found few problems, but the public and some scientists are not reassured. (p. 9)

Coverstory: Instrumentation: Firms Help Meet Demand For Equipment

(pp. 14-15)

July 11, 2011

Coverstory: Electronic Chemicals

Behind the scenes, materials suppliers help make electronics faster, brighter, smaller, cheaper. (p. 9)

Coverstory: Materials Enable Memory Advances

Development of emerging memory architectures relies on material innovations. (pp. 10-13)

Coverstory: A Tiny Problem

Lithography industry extends old technique in face of setbacks with new one. (pp. 14-16)

Coverstory: Bright Outlook For LED Precursor

Large new applications are behind boom in the trimethylgallium business. (pp. 17-18)

July 4, 2011

Coverstory: Facts & Figures Of The Chemical Industry

A leaner chemical industry made the most of a shallow recovery. (p. 33)

Coverstory: A Long Year of Demand Recovery

Cost cutting boosted finances, but it took four quarters for sales volumes to return. (pp. 34-49)

Coverstory: Chemical Sector's Jobless Recovery

A wobbly rebound, high productivity, and pharma mergers prevented employment growth. (pp. 50-51)

Coverstory: Output Ramps Up In All Regions

Chemical production increased markedly over that in 2009, thanks to demand from developing economies. (pp. 55-63)

Coverstory: Growing Economies Pump Up Commerce

Jump in trade was a measure of recovery for the chemical industry. (pp. 64-67)

June 27, 2011

Coverstory: International Year of Chemistry

Chemistry's contributions to the well-being of humanity are being celebrated in 2011. (p. 39)

Coverstory: Chemistry Boosts Global Sustainable Development

Food, environmental, green, and industrial chemistry sectors promote development and education in Africa, worldwide. (pp. 41-45)

Coverstory: Maximizing The Benefits Of Food

With the help of chemistry, we are eating safer, healthier, and more sustainable food than ever before. (pp. 46-51)

Coverstory: Plant Medicines Key to Global Health

Paradigm shifts could improve quality, availability, and sustainability of traditional and nontraditional medicines. (pp. 52-56)

Coverstory: Medicine Quality Faces Challenges

Access, innovation, and globalization: opportunities and hurdles in providing high-quality drugs to the world's population. (pp. 58-61)

Coverstory: Twenty Years OF Green Chemistry

Chemists have worked hard to build awareness of and reduce hazardous chemical use over the past two decades. (pp. 62-65)

Coverstory: Marie Curie

First female chemistry Nobelist owes much of her success to fierce professional and personal determination. (pp. 66-70)

June 20, 2011

Coverstory: After The Break-Up

The end of a partnership with big pharma brings both opportunity and challenge for biotech firms. (pp. 15-20)

June 13, 2011

Coverstory: Building Small

Nanotechnology makes inroads in the construction industry. (pp. 12-17)

June 6, 2011

Coverstory: Bisphenol A

A rift persists between safety assessments of the man-made estrogen mimic. (p. 13)

Coverstory: Debating BPA's Toxicity

The precautionary principle serves as a dividing line in arguments over the safety of bisphenol A. (pp. 14-19)

Coverstory: Exposure Routes Confound BPA Debate

Beyond bisphenol A in food and drink containers, people face many sources of endocrine disrupters in everyday life. (pp. 20-22)

Coverstory: BPA Is Indispensible For Making Plastics

Chemists struggle to find endocrine-disrupter-free alternatives that match bisphenol A's cost and performance. (Web Exclusive)

Coverstory: BPA Chronology

Dozens of &EN articles published since 2007 have covered the BPA story. (Web Exclusive)

May 30, 2011

Coverstory: Improving Peptides

Small firms develop better peptide drug candidates to expand this pharmaceutical class and attract big pharma partners. (pp. 13-20)

Coverstory: Making Peptides At Large Scale

Efficient synthesis is helping to renew interest in the peptide drug market. (pp. 21-25)

May 23, 2011

Coverstory: Japan Rebuilds

Two months after a devastating earthquake and tsunami, Japan's chemical enterprise is on a determined path to recovery. (p. 13)

Recovering Research

Japanese universities, scientific facilities damaged in quake face up to a year to rebuild. (pp. 14-16)

Japan's Chemical Industry Rebounds

Companies are rapidly rehabilitating their facilities but will face power shortages in coming months. (pp. 17-18)

U.S. Boosts Scrutiny Of Nuclear Reactors

Officials say lessons learned from Japan will make nuclear power safer in future. (pp. 19-20)

May 16, 2011

Coverstory: Shock To The System

Big questions about drug safety arise in the wake of rampant supply-chain globalization. (pp. 11-15)

Battle For Europe: API Producers Make Headway In Brussels On Drug Safety Regulations

(p. 13)

May 9, 2011

Coverstory: The Next Generation In Genome Sequencing

Advances in technology create new challenges in data analysis. (pp. 17-21)

Research At The Heretical Edge

Johnson & Johnson shares a cloud-hosted data management system with its brethren in big pharma. (pp. 22-23)

May 2, 2011

Coverstory: Storm Over Silicones

Some cosmetic ingredient makers defend cyclic methylsiloxanes as competitors tout substitutes. (pp. 10-13)

April 25, 2011

Coverstory: Top Instrument Firms

Mergers and acquisitions alter the landscape in C&EN's ranking of leading analytical and life sciences instrumentation companies. (pp. 13-19)

April 18, 2011

Coverstory: Germinating Pesticides

Chemical firms change course in the search for new products for agriculture. (pp. 13-17)

Life After Roundup

Weed Science: The emergence of glyphosate-resistant weeds has put agriculture in a quandary. (Web Exclusive)

Going Mainstream: Biopesticide Producers Look Beyond Organic Growers

(p. 16)

April 11, 2011

Coverstory: PI3K At The Clinical Crossroads

After a frenzy to develop better and more selective PI3K inhibitors, companies now must figure out how to use them in cancer patients. (pp. 15-19)

April 4, 2011

Coverstory: Pittcon 2011

Year of recovery brings increases in conference attendance, mergers and acquisitions, and instrumentation sales. (pp. 37-40)

Coverstory: Analyze This: Mass Spec And Spot Analysis Highlighted At C&EN Pittcon Luncheon

(p. 40)

Coverstory: Carbon-Based Microdevices

Materials from the semiconductor industry allow scientists to 'machine' carbon. (pp. 41-42)

New And Notable At Pittcon

Scientific Instrumentation And More. (pp. 43-46)

New And Notable At Pittcon: Pittcon Editors' Award Winners

(pp. 43-44)

New And Notable At Pittcon: Analytical Instrumentation

(p. 44)

New And Notable At Pittcon: Lab Optimization

(pp. 44-45)

New And Notable At Pittcon: Chromatography & Separations

(p. 46)

New And Notable At Pittcon: Pittcon Potpourri

Thermo Fisher Displays Multiple New Instruments And Bruker Showcases Product Line. (pp. 45-46)

March 28, 2011

Coverstory: Scientist-Diplomat Extraordinaire

Straddling the U.S. and Middle East, Priestley Medalist Ahmed H. Zewail thrives at the interface of science, culture, and international affairs. (pp. 12-16)

Coverstory: Dreaming The Future

(pp. 17-21)

March 21, 2011

Coverstory: Pharma Outsourcing

Successful chemistry outsourcing service providers bring an intellectual contribution to the projects they carry out for their drug company partners. (p. 15)

Coverstory: Giving New Life To An Old Molecule

Case Study #1: Novasep helps Provepharm quickly scale up to make a better pharmaceutical ingredient. (pp. 16-17)

Coverstory: Betting On Boron

Case Study #2: Naeja helps Anacor realize its goal of boron-containing pharmaceuticals. (pp. 18-19)

Coverstory: Rethinking A Renin Inhibitor

Case Study #3: Vitae turns to Solvias for a new synthetic route as well as Phase II clinical production. (pp. 20-21)

March 14, 2011

Coverstory: From Picture To Pill

Debut of G-protein-coupled receptors will bolster drugmakers' tool kits. (pp. 13-18)

Spin-offs: Meet The Structure Specialists

(pp. 18-19)

March 7, 2011

Coverstory: Battling The Bedbug Epidemic

Chemical controls, government action, and personal vigilance are all required to tame the outbreak. (pp. 13-18)

February 28, 2011

Coverstory: More Support For Science

President's 2012 budget proposal provides continued growth for science. (pp. 13-25)

NSF: President Keeps Agency On Doubling Track

NIH: Agency Growth Matches Biomedical Inflation Rate

Defense: Science And Technology Funding Is Down

DHS: Additional Funds For National Security R&D

Energy: Support Up For Renewable Energy

Commerce: Request Provides Gains For Laboratory Services

NASA: Funding Is Flat, But Earth Science Programs Grow

Agriculture: Research Funds Are Down

EPA: Budget Cut, But Gains In Select Areas

Interagency Initiatives: Education, Climate Science, And Nanotech All Grow

February 21, 2011

Coverstory: Big Pharma's Last Shot

Firms hope they can overcome decadelong drop in productivity through efficient innovation. (pp. 12-16)

February 14, 2011

Coverstory: Race To The Pump

Biofuel technologies vie to provide a sustainable supply of transportation fuels. (pp. 11-17)

C&EN Talks With Bruce Dale

Michigan State chemical engineer takes a critical look at the pluses and minuses of biofuels. (WEB EXCLUSIVE)

February 7, 2011

Coverstory: Monitoring The Skies

Field campaigns target the chemistry behind air quality and climate. (pp. 11-15)

Destined For Orbit: Satellite Will Eye Earth's Aerosols

Instrumentation: Aerodyne Spectrometers Ease Particle Research

January 31, 2011

Coverstory: Custom Chemicals

Slowly recovering in 2010, contract manufacturers envision a path toward growth by responding to marketplace shifts. (pp. 13-19)

Coverstory: Fulfilling Capacity

Despite industry-wide consolidation, pharmaceutical companies continue to offer contract manufacturing. (pp. 21-26)

January 24, 2011

Coverstory: Goodbye, Phosphates

Struggling automatic dishwasher detergent manufacturers turn to chemical industry for help with phosphate-free formulas. (pp. 12-17)

January 17, 2011

Coverstory: Technology Renews A Basic Approach

Dried blood spots offer advantages, but also challenges, for pharmaceutical analysis. (pp. 13-17)

January 10, 2011

Coverstory: World Chemical Outlook

The chemical industry predicts better times in 2010. (pp. 9-17)

Markets

Cleantech: Venture Capitalists Seek To Lower Risk

Electronic Materials: Growth Will Decelerate After Bumper Year

Finance: Chemical Firms Have Cash To Spend But Are Wary Of Large Investments

Fine Chemicals: Executives See An 'Okay' Year Ahead

Inorganics: After A Rough Spell, Steadier Times Lie Ahead

Instrumentation: Year Ahead Will Test Robustness Of The Recovery

Paints And Coatings: Recovery Will Come Slowly In Developed Economies

Petrochemicals: North American Firms Are Pleasantly Surprised By A Robust Market

Pharmaceuticals: Small, Targeted Deals Will Continue In 2011

Specialties: World Demand Will Grow, Fueled By Asia And South America

Regions

Asia: Growth Is Strong, But Clouds Loom

Canada: Chemical Firms Look South And Seek Government Incentives For Growth

Europe: Slower Growth To Follow Strong But Varied Rebound In 2011

Latin America: Buoyant Chemical Companies Keep A Cautious Eye On The Rest Of The World

Middle East: The Region Wants To Beat Its Cracker Addiction

U.S. Weak Domestic Demand Will Be Offset By Strong Exports, Low Natural Gas Prices

January 3, 2011

Coverstory: President's Message

ACS President Nancy Jackson lays out her plan for 2011, the International Year of Chemistry. (pp. 2-4)