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January 17, 2011 - Volume 89, Number 3
- p. 31
Science & Technology Concentrates
More Science & Technology Concentrates
- 3-D Nanoscale Chemical Maps Of Teeth
- Tomography analysis reveals compositional differences in microscopic tooth structures
- Interfacial Properties Boost Lasing by Quantum Dots
- Two-monolayer-thin alloy layer in core-shell nanocrystals aids optics applications
- Amoebas Found In Treated Drinking Water Worldwide
- Water Treatment: Free-living amoebas that evade common disinfection treatments can host Legionella and other hazardous microorganisms
- Natural Product Sidesteps Drug Resistance In Yeast
- Enzyme inhibitor could lead to new pharmaceuticals
- Red Blood Cell Mimics Circulate Longer When Flexible
- Cross-linking chemistry imparts bio-like property to hydrogel microparticles
- Arsenate-Phosphate Debate Continues
- Review suggests controversy should stimulate interest in studies of enzyme promiscuity
- Gaseous Carbonic Acid Trapped And Analyzed
- Elusive molecule shown to exist in monomeric and dimeric forms
- One-Pot Method Produces Pyrroles
- Reaction converts aromatic alkynes to heterocycles in presence of palladium catalyst
Topics Covered
More Science Stories
October 24, 2011
Bryostatins Retain Promise
(October 24, 2011 | Vol. 89 Issue 43 | pp. 10-17)New results in total synthesis reinvigorate a 40-year-old field of research.
For Cave's Art, An Uncertain Future
(October 24, 2011 | Vol. 89 Issue 43 | pp. 38-40)Disagreement on conservation course of action complicates a potential reopening.
Cancer Stem Cells
(October 24, 2011 | Vol. 89 Issue 43 | pp. 41-43)Researchers zero in on the pathways that allow cancer to bounce back after treatment.
What's That Stuff? Blue Jeans
(October 24, 2011 | Vol. 89 Issue 43 | p. 44)Making the iconic pants requires both color-addition and color-removal chemistry.
Shedding Nanoparticles
(October 24, 2011 | Vol. 89 Issue 43 | p. 5)Materials Science: Chemists observe metal objects sloughing off ions to form nanoparticles.
Modifying Messenger RNA
(October 24, 2011 | Vol. 89 Issue 43 | p. 7)Chemical Biology: Methylated bases in mRNA may have roles in gene regulation and obesity.
Lab-On-A-Chip For Planets, Moons
(October 24, 2011 | Vol. 89 Issue 43 | p. 8)Microfluidics: Automated chip is designed to detect extraterrestrial amino acids.
New Editor For Analytical Chemistry
(October 24, 2011 | Vol. 89 Issue 43 | p. 9)Publishing: Jonathan Sweedler to take the helm.
Science & Technology Concentrates
(October 24, 2011 | Vol. 89 Issue 43 | p. 37)
October 17, 2011
Improving Shop Safety
(October 17, 2011 | Vol. 89 Issue 42 | pp. 56-57)Yale updates policies on machine shop use after student death.
Cleaning Acrylics
(October 17, 2011 | Vol. 89 Issue 42 | pp. 58-59)Conservation scientists seek new ways to keep modern paintings looking their best.
Detecting H2S In Vivo (Member Content)
(October 17, 2011 | Vol. 89 Issue 42 | p. 60)Studies could lead to sensitive and selective analyses for tiny signaling agent.
Rules For Design
(October 17, 2011 | Vol. 89 Issue 42 | p. 9)Materials Science: Guidelines predict structures formed by nanoparticles and DNA linkers.
Identifying Modified Cells
(October 17, 2011 | Vol. 89 Issue 42 | p. 11)Molecular Biology: Technique tags and enriches cells genetically altered by nucleases.
Linker-Free Molecular Wires
(October 17, 2011 | Vol. 89 Issue 42 | p. 12)Electronics: Metal-carbon bonds increase electrical conductance.
Asymmetry From A Guest
(October 17, 2011 | Vol. 89 Issue 42 | p. 13)Stereochemistry: Enzymelike pocket that hosts chiral species controls catalyst's enantioselectivity.
Science & Technology Concentrates
(October 17, 2011 | Vol. 89 Issue 42 | pp. 54-56)
A new synthetic method simplifies the production of 2,4-disubstituted pyrrole heterocycles—an important class of structures common in the chemistry of natural products and pharmaceuticals. Barry M. Trost and colleagues at Stanford University have been developing one-pot reactions of substituted alkynes to create important organic building blocks—an efficient strategy that maximizes atom economy. In this most recent case, Trost’s group, which includes Jean-Philip Lumb and Joseph M. Azzarelli, describes the synthesis of a number of 2,4-disubstituted pyrroles (shown), which were prepared from various substituted aromatic alkynes in the presence of a palladium catalyst (J. Am. Chem. Soc., DOI: 10.1021/ja110117g). The process is tolerant to moisture and air and can be carried out at room temperature. The authors also report that intermediates produced during the reaction can be captured and further functionalized to species such as 2,3,4-trisubstituted pyrroles and 3-substituted pyrrolidin-2-ones.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © 2011 American Chemical Society
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