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January 24, 2011 - Volume 89, Number 4
- p. 31
Science & Technology Concentrates
More Science & Technology Concentrates
- Knockout Pictures
- X-ray structures of general anesthetics binding to an ion channel could aid search for new anesthetics.
- Death By Reduction
- Chemical Biology: A cysteine-rich defensin peptide turns antimicrobial when reduced.
- Glutamine Probe Images Tumors
- Scientists could use the 18F-glutamine derivatives to track tumors that use glutamine as an alternative energy source.
- Bringing Disorder To Titanium Dioxide
- Change allows the photocatalyst to absorb beyond the ultraviolet range, into visible and infrared spectrum.
- Relativity Powers Batteries
- Lead-acid car batteries’ power stems from relativistic effects.
Topics Covered
More Science Stories
October 24, 2011
Bryostatins Retain Promise
(October 24, 2011 | Vol. 89 Issue 43 | pp. 10-17)New results in total synthesis reinvigorate a 40-year-old field of research.
For Cave's Art, An Uncertain Future
(October 24, 2011 | Vol. 89 Issue 43 | pp. 38-40)Disagreement on conservation course of action complicates a potential reopening.
Cancer Stem Cells
(October 24, 2011 | Vol. 89 Issue 43 | pp. 41-43)Researchers zero in on the pathways that allow cancer to bounce back after treatment.
What's That Stuff? Blue Jeans
(October 24, 2011 | Vol. 89 Issue 43 | p. 44)Making the iconic pants requires both color-addition and color-removal chemistry.
Shedding Nanoparticles
(October 24, 2011 | Vol. 89 Issue 43 | p. 5)Materials Science: Chemists observe metal objects sloughing off ions to form nanoparticles.
Modifying Messenger RNA
(October 24, 2011 | Vol. 89 Issue 43 | p. 7)Chemical Biology: Methylated bases in mRNA may have roles in gene regulation and obesity.
Lab-On-A-Chip For Planets, Moons
(October 24, 2011 | Vol. 89 Issue 43 | p. 8)Microfluidics: Automated chip is designed to detect extraterrestrial amino acids.
New Editor For Analytical Chemistry
(October 24, 2011 | Vol. 89 Issue 43 | p. 9)Publishing: Jonathan Sweedler to take the helm.
Science & Technology Concentrates
(October 24, 2011 | Vol. 89 Issue 43 | p. 37)
October 17, 2011
Improving Shop Safety
(October 17, 2011 | Vol. 89 Issue 42 | pp. 56-57)Yale updates policies on machine shop use after student death.
Cleaning Acrylics
(October 17, 2011 | Vol. 89 Issue 42 | pp. 58-59)Conservation scientists seek new ways to keep modern paintings looking their best.
Detecting H2S In Vivo (Member Content)
(October 17, 2011 | Vol. 89 Issue 42 | p. 60)Studies could lead to sensitive and selective analyses for tiny signaling agent.
Rules For Design
(October 17, 2011 | Vol. 89 Issue 42 | p. 9)Materials Science: Guidelines predict structures formed by nanoparticles and DNA linkers.
Identifying Modified Cells
(October 17, 2011 | Vol. 89 Issue 42 | p. 11)Molecular Biology: Technique tags and enriches cells genetically altered by nucleases.
Linker-Free Molecular Wires
(October 17, 2011 | Vol. 89 Issue 42 | p. 12)Electronics: Metal-carbon bonds increase electrical conductance.
Asymmetry From A Guest
(October 17, 2011 | Vol. 89 Issue 42 | p. 13)Stereochemistry: Enzymelike pocket that hosts chiral species controls catalyst's enantioselectivity.
Science & Technology Concentrates
(October 17, 2011 | Vol. 89 Issue 42 | pp. 54-56)
Doctors may soon have a new tool for spying on growing tumors, thanks to chemists at the University of Pennsylvania. Researchers led by Wenchao Qu and Hank F. Kung, have developed a simple synthesis for 18F-glutamine derivatives, which could serve as positron emission tomography probes for following tumors that use glutamine as an alternative source of energy (J. Am. Chem. Soc., DOI: 10.1021/ja109203d). Because of 18F’s 110-minute half-life, the researchers needed a synthesis that incorporated the halide in the final stages. They also wanted a stereospecific route. To that end, they first used a Passerini three-component reaction to assemble the amino acid’s basic skeleton and then incorporated the radioactive fluorine using nucleophilic fluoride under neutralizing conditions. In vitro studies with certain tumor cells suggest uptake is highly specific for both fluorinated isomers of the natural amino acid. The (2S,4R) isomer (shown) is being further evaluated as a biological probe.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © 2011 American Chemical Society
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