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January 31, 2011 - Volume 89, Number 5
- p. 45
Science & Technology Concentrates
More Science & Technology Concentrates
- Cows Aid Quest For Biofuels
- By sequencing the DNA of cow gut microbes, researchers uncover a treasure trove of cellulose-degrading enzymes
- Chemical Lures For Cockroaches
- Researchers ID the compounds in stale beer and peanut butter that make roaches come running
- Extreme Hydrogen ‘Isotopes’ Illuminate Reaction Kinetics
- Using muons to create light and heavy hydrogen mimics, chemists upgrade the kinetic isotope effect
- Probing Chemical Timekeeping
- Scientists find a new role for posttranslational modification in circadian rhythms
- A Little Tug Speeds Up Collagen Cleavage
- Mechanical stress increases the rate at which structural collagen is degraded by an enzyme
- Nickel Complex’s Magnetic Switch
- Light-driven isomerization changes molecule’s coordination and thus its magnetic properties
- Biohybrid Catalyst Rapidly Produces H2
- Photosystem I’s photosynthetic properties are exploited by coupling it to platinum nanoparticles
- Target Of Traditional Chinese Medicine Triptolide Found
- Uncovering natural product’s cellular target will facilitate the design of new anticancer and other drug leads
Topics Covered
More Science Stories
October 24, 2011
Bryostatins Retain Promise
(October 24, 2011 | Vol. 89 Issue 43 | pp. 10-17)New results in total synthesis reinvigorate a 40-year-old field of research.
For Cave's Art, An Uncertain Future
(October 24, 2011 | Vol. 89 Issue 43 | pp. 38-40)Disagreement on conservation course of action complicates a potential reopening.
Cancer Stem Cells
(October 24, 2011 | Vol. 89 Issue 43 | pp. 41-43)Researchers zero in on the pathways that allow cancer to bounce back after treatment.
What's That Stuff? Blue Jeans
(October 24, 2011 | Vol. 89 Issue 43 | p. 44)Making the iconic pants requires both color-addition and color-removal chemistry.
Shedding Nanoparticles
(October 24, 2011 | Vol. 89 Issue 43 | p. 5)Materials Science: Chemists observe metal objects sloughing off ions to form nanoparticles.
Modifying Messenger RNA
(October 24, 2011 | Vol. 89 Issue 43 | p. 7)Chemical Biology: Methylated bases in mRNA may have roles in gene regulation and obesity.
Lab-On-A-Chip For Planets, Moons
(October 24, 2011 | Vol. 89 Issue 43 | p. 8)Microfluidics: Automated chip is designed to detect extraterrestrial amino acids.
New Editor For Analytical Chemistry
(October 24, 2011 | Vol. 89 Issue 43 | p. 9)Publishing: Jonathan Sweedler to take the helm.
Science & Technology Concentrates
(October 24, 2011 | Vol. 89 Issue 43 | p. 37)
October 17, 2011
Improving Shop Safety
(October 17, 2011 | Vol. 89 Issue 42 | pp. 56-57)Yale updates policies on machine shop use after student death.
Cleaning Acrylics
(October 17, 2011 | Vol. 89 Issue 42 | pp. 58-59)Conservation scientists seek new ways to keep modern paintings looking their best.
Detecting H2S In Vivo (Member Content)
(October 17, 2011 | Vol. 89 Issue 42 | p. 60)Studies could lead to sensitive and selective analyses for tiny signaling agent.
Rules For Design
(October 17, 2011 | Vol. 89 Issue 42 | p. 9)Materials Science: Guidelines predict structures formed by nanoparticles and DNA linkers.
Identifying Modified Cells
(October 17, 2011 | Vol. 89 Issue 42 | p. 11)Molecular Biology: Technique tags and enriches cells genetically altered by nucleases.
Linker-Free Molecular Wires
(October 17, 2011 | Vol. 89 Issue 42 | p. 12)Electronics: Metal-carbon bonds increase electrical conductance.
Asymmetry From A Guest
(October 17, 2011 | Vol. 89 Issue 42 | p. 13)Stereochemistry: Enzymelike pocket that hosts chiral species controls catalyst's enantioselectivity.
Science & Technology Concentrates
(October 17, 2011 | Vol. 89 Issue 42 | pp. 54-56)
Mechanical stress increases the rate at which structural collagen is degraded by the enzyme matrix metalloproteinase-1 (MMP-1), according to a study by Stanford University chemical engineers (J. Am. Chem. Soc., DOI: 10.1021/ja109972p). Mechanical stress is known to affect the composition and structure of the collagen-containing extracellular matrix (ECM) in embryonic development and some diseases. But how this force exerts its influence is poorly understood. Alexander R. Dunn, Arjun S. Adhikari, and Jack Chai used a magnetic bead assay to measure the effect of force on the rate at which MMP-1 snips collagen. The researchers attached one end of each collagen trimer to a surface and the other end to a magnetic bead. Bead detachment from the surface signaled that MMP-1 had cleaved the collagen. They found that a mechanical load of 13 piconewtons increased the rate of collagen cleavage 81-fold. The team proposes a model in which the mechanical force stretches and unwinds the collagen, allowing MMP-1 to rapidly cleave the collagen triple helix. The findings suggest “a possible role for mechanical force in the regulation of ECM remodeling,” the researchers write.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © 2011 American Chemical Society
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