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June 20, 2011 - Volume 89, Number 25
- p. 32
Science & Technology Concentrates
More Science & Technology Concentrates
- Marking Sugar’s Spot
- Enzyme structure reveals the secret behind the activated nitrogen that facilitates important protein modifications.
- Spinning Improves NMR Of Large Proteins
- Ultracentrifugation-NMR method reveals tough-to-determine structures
- Ursolic Acid Might Keep The Doctor Away
- Natural product found in apples is identified as a promising compound to treat age- and disease-related muscle atrophy.
- Fast, Sensitive DNA Sequencing
- Combining pyrosequencing and fluorescence measurements leads to a quick and sensitive method for analyzing DNA.
- Optical Imaging Of Ligand-Protein Binding
- Nanoscale microscopy method provides high spatial and temporal resolution.
Topics Covered
More Science Stories
October 24, 2011
Bryostatins Retain Promise
(October 24, 2011 | Vol. 89 Issue 43 | pp. 10-17)New results in total synthesis reinvigorate a 40-year-old field of research.
For Cave's Art, An Uncertain Future
(October 24, 2011 | Vol. 89 Issue 43 | pp. 38-40)Disagreement on conservation course of action complicates a potential reopening.
Cancer Stem Cells
(October 24, 2011 | Vol. 89 Issue 43 | pp. 41-43)Researchers zero in on the pathways that allow cancer to bounce back after treatment.
What's That Stuff? Blue Jeans
(October 24, 2011 | Vol. 89 Issue 43 | p. 44)Making the iconic pants requires both color-addition and color-removal chemistry.
Shedding Nanoparticles
(October 24, 2011 | Vol. 89 Issue 43 | p. 5)Materials Science: Chemists observe metal objects sloughing off ions to form nanoparticles.
Modifying Messenger RNA
(October 24, 2011 | Vol. 89 Issue 43 | p. 7)Chemical Biology: Methylated bases in mRNA may have roles in gene regulation and obesity.
Lab-On-A-Chip For Planets, Moons
(October 24, 2011 | Vol. 89 Issue 43 | p. 8)Microfluidics: Automated chip is designed to detect extraterrestrial amino acids.
New Editor For Analytical Chemistry
(October 24, 2011 | Vol. 89 Issue 43 | p. 9)Publishing: Jonathan Sweedler to take the helm.
Science & Technology Concentrates
(October 24, 2011 | Vol. 89 Issue 43 | p. 37)
October 17, 2011
Improving Shop Safety
(October 17, 2011 | Vol. 89 Issue 42 | pp. 56-57)Yale updates policies on machine shop use after student death.
Cleaning Acrylics
(October 17, 2011 | Vol. 89 Issue 42 | pp. 58-59)Conservation scientists seek new ways to keep modern paintings looking their best.
Detecting H2S In Vivo (Member Content)
(October 17, 2011 | Vol. 89 Issue 42 | p. 60)Studies could lead to sensitive and selective analyses for tiny signaling agent.
Rules For Design
(October 17, 2011 | Vol. 89 Issue 42 | p. 9)Materials Science: Guidelines predict structures formed by nanoparticles and DNA linkers.
Identifying Modified Cells
(October 17, 2011 | Vol. 89 Issue 42 | p. 11)Molecular Biology: Technique tags and enriches cells genetically altered by nucleases.
Linker-Free Molecular Wires
(October 17, 2011 | Vol. 89 Issue 42 | p. 12)Electronics: Metal-carbon bonds increase electrical conductance.
Asymmetry From A Guest
(October 17, 2011 | Vol. 89 Issue 42 | p. 13)Stereochemistry: Enzymelike pocket that hosts chiral species controls catalyst's enantioselectivity.
Science & Technology Concentrates
(October 17, 2011 | Vol. 89 Issue 42 | pp. 54-56)
Fluorogenic pyrosequencing, a new DNA sequencing method, combines the speed and one-color detection of conventional pyrosequencing with the sensitivity of fluorescence-based methods (Nat. Methods, DOI: 10.1038/nmeth.1629). In the new method, as in other sequencing-by-synthesis methods, the sequence of a target DNA molecule is determined by identifying the order in which nucleotides are incorporated when that DNA is used as a template for DNA synthesis. X. Sunney Xie and coworkers at Harvard University label all four nucleotides with an identical dye, which is nonfluorescent when it is attached to a nucleotide. Adding a nucleotide to the growing DNA strand releases the dye, which becomes fluorescent. The dye is trapped in polymeric microreactors, in which the DNA is tethered. The fluorescence is detected and the dye is washed away. Repeating the cycle many times with each of the four nucleotides reveals the sequence of the DNA template. Xie and coworkers believe the method will offer low cost, high throughput, and rapid turnaround.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © 2011 American Chemical Society
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