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July 11, 2011 - Volume 89, Number 28
- p. 31
Science & Technology Concentrates
J. Am. Chem. Soc.
The nucleus of a living cancer cell lights up because of this fluorescing iridium complex.
More Science & Technology Concentrates
- Stem Cells Have Unusual Base
- 5-Formylcytosine has been discovered as a novel genetic base in embryonic stem cell DNA
- Goldilocks Effect Could Govern Reactive Oxygen Species
- It turns out that having just the right number of radicals in cells—not too many or too few—helps inhibit cancers
- Iridium Illuminates Nuclei Of Living Cells
- A metal complex turns on and lights up nuclei by binding to histidine rather than to DNA like other imaging agents
- Hydrogen Peroxide Detected In Space
- H2O2 is spotted in interstellar space for the first time, a finding that could refine astrochemical models involving H2O and O2
- Antibody One-Two Could Knock Out Flu
- Newfound antibody complements a previous antibody's flu-deactivating activity and could enable a universal flu vaccine
- Raman Senses Sugars On Proteins
- Chemists demonstrate that Raman spectroscopy can differentiate between native and glycosylated forms of proteins
- How Giant Algae Heal Cuts And Scrapes
- A sulfated coumarin is the linchpin of a marine dweller's approach to forming gelatinous plugs at injury sites
- Scientists Go To Great Depths For Rare-Earth Elements
- Deep-sea mud in the Pacific Ocean contains enough of the metals to meet the world's growing demand
Topics Covered
Latest News
October 28, 2011
Speedy Homemade-Explosive Detector
Forensic Chemistry: A new method could increase the number of explosives detected by airport screeners.
Solar Panel Makers Cry Foul
Trade: U.S. companies complain of market dumping by China.
Novartis To Cut 2,000 Jobs
Layoffs follow similar moves by Amgen, AstraZeneca.
Nations Break Impasse On Waste
Environment: Ban to halt export of hazardous waste to developing world.
New Leader For Lawrence Livermore
Penrose (Parney) Albright will direct DOE national lab.
Hair Reveals Source Of People's Exposure To Mercury
Toxic Exposure: Mercury isotopes in human hair illuminate dietary and industrial sources.
Why The Long Fat?
Cancer Biochemistry: Mass spectrometry follows the metabolism of very long fatty acids in cancer cells.
An iridium complex turns on and lights up the nuclei of living cells by binding to histidine rather than to DNA, unlike other nuclear imaging agents, reports Fuyou Li and colleagues of China’s Fudan University (J. Am. Chem. Soc., DOI: 10.1021/ja202344c). The complex, [Ir(polypyridyl)2(dimethylsulfoxide)2]PF6, demonstrates little fluorescence as a solid or alone in solution. But when the complex binds to free histidine or histidine-containing proteins and is excited by 488-nm light, it fluoresces intensely. Although the complex can react with cytoplasmic proteins, an active transport mechanism—possibly a transport protein—spontaneously brings it into living cells and segregates it to the nucleus. The complex stains cellular nuclei within a few minutes and has low toxicity, the researchers note.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © 2011 American Chemical Society
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