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September 5, 2011 - Volume 89, Number 36
- p. 55
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New results in total synthesis reinvigorate a 40-year-old field of research.
Disagreement on conservation course of action complicates a potential reopening.
Researchers zero in on the pathways that allow cancer to bounce back after treatment.
Making the iconic pants requires both color-addition and color-removal chemistry.
Materials Science: Chemists observe metal objects sloughing off ions to form nanoparticles.
Chemical Biology: Methylated bases in mRNA may have roles in gene regulation and obesity.
Microfluidics: Automated chip is designed to detect extraterrestrial amino acids.
Publishing: Jonathan Sweedler to take the helm.
Yale updates policies on machine shop use after student death.
Conservation scientists seek new ways to keep modern paintings looking their best.
Studies could lead to sensitive and selective analyses for tiny signaling agent.
Materials Science: Guidelines predict structures formed by nanoparticles and DNA linkers.
Molecular Biology: Technique tags and enriches cells genetically altered by nucleases.
Electronics: Metal-carbon bonds increase electrical conductance.
Stereochemistry: Enzymelike pocket that hosts chiral species controls catalyst's enantioselectivity.
A new type of nanoparticle works as a label for five types of microscopy. Different microscopy methods usually require different types of probes, making the resulting images difficult to correlate. Chemistry professor Jie Zheng and graduate student Chen Zhou of the University of Texas, Dallas, reported that metal nanoparticles can be used as universal probes for five types of microscopy—bright field, dark field, fluorescence, Raman, and two-photon excitation. Zheng attributed the particles’ versatility to a structural phenomenon that he called the grain-size effect. “Each individual nanoparticle is composed of many tiny grains,” Zheng said. Those grains have two distinct size distributions within the particles. That structure gives each highly polycrystalline silver nanoparticle its strong and robust single-particle luminescence, Zheng said. His team decorated the nanoparticle’s surface with peptides that bind to integrin receptors on cell surfaces. With the probe, the researchers imaged brain cancer cells at the single-particle level using multiple types of microscopy.
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