—Vast variability found in Alzheimer’s gene “Researchers find thousands of variants in amyloid precursor in diseased brains” Neuroscientists have long wondered how a supposedly static genome could give rise to the brain’s incredible diversity in health and disease. Now researchers have found that a key gene implicated in the pathology of Alzheimer’s disease is highly variable. The findings could help explain outcomes as diverse as how we store memory, and in the case of Alzheimer’s disease, how we lose it (Nature 2018, DOI: 10.1038/s41586-018-0718-6). Jerold Chun, a neuroscientist at Sanford Burnham Prebys Medical Discovery Institute and the University of California, San Diego, looked for variations in APP, the gene coding for the amyloid precursor protein.
by Megha Satyanarayana |
November 28, 2018