—Making ring compounds for DNA-encoded libraries “Adding magnesium enables ring-closing metathesis reactions on DNA-tagged molecules” A simple tweak to a tool for making macrocyclic compounds could help increase the diversity of DNA-encoded libraries used by drug developers to rapidly screen and identify promising drug candidates (Bioconjugate Chem. 2017, DOI: 10.1021/acs.bioconjchem.7b00292). Building such libraries involves facilitating reactions between small molecules tagged with short, unique DNA sequences to create myriad products, which are then tagged with additional unique DNA sequences. The DNA serves as a sort of bar code to identify the compounds in a library that successfully bind to a particular drug target.
by XiaoZhi Lim, special to C&EN |
July 17, 2017