—Cancer: A Protein Aggregation Disease “Misfolded and aggregated proteins–longtime hallmarks of brain disorders–also appear to play a role in cancer” Aggregated proteins, the longtime hallmarks of neurodegenerative disorders such as Alzheimer’s disease, also play a role in cancer, new research suggests. Preventing aggregation of proteins, such as the tumor suppressor protein p53, could thus become a strategy for anticancer drug development. A team led by Joost Schymkowitz and Frederic Rousseau at Catholic University, in Leuven, Belgium, took a look at p53, which binds DNA to help regulate cell cycles.
by Sarah Everts |
March 28, 2011