—A Mechanism For Protein Entry Into A Cell Nucleus “” Proteins move into the nucleus of a cell to regulate various biochemical pathways, with different types of proteins using different means to penetrate the nucleus. Researchers at Weizmann Institute of Science, in Rehovot, Israel, have now figured out the mechanism underlying one of these entry methods (Mol. Cell 2008, 31, 850). Most proteins destined for the nucleus possess a domain known as the nuclear localization signal. "Importin" proteins bind to this domain and help move the bound protein into the nucleus through a pore in the nuclear membrane. But some incoming proteins lack the nuclear localization signal domain.
by Sophie L. Rovner |
October 06, 2008