—DNA-Programmed Synthesis Of Tissues “Synthetic Biology: Method directs layer-by-layer growth of three-dimensional tissues” Figuring out how tissue architecture affects tissue function is hard to do without a way to control that architecture. Zev J. Gartner of the University of California, San Francisco, and coworkers do it via a DNA hybridization method that builds organlike tissues layer-by-layer (Nat.
by Celia Henry Arnaud | September 07, 2015
—Engineered tissue goes bigger, lives longer “Crafty chemistry and bioprinting creates thicker tissue with vasculature” Engineered, living tissue could help scientists and doctors test for drug safety or even repair injured tissue. Researchers have already used cells and biocompatible polymers to build materials that look and behave like living tissue in many ways.
by Matt Davenport | March 09, 2016
—Growing liver tissue from seed “Hydrogel patterned with cells expands into functioning liver tissue in response to liver damage” The ability to grow new organs from engineered tissue could reduce the need for whole-organ transplantation. But growing new organs with the correct architecture is hard for large, complex organs such as the liver.
by Celia Henry Arnaud | July 24, 2017
—Newly Engineered Tissue Sheds Light On Fibrocartilage “Tissue Engineering: Study finds that the size, but not the number, of proteoglycan domains increases throughout development and aging” Fibrocartilage is a type of tissue, such as that in the knee meniscus, that consists of aligned fibrous microdomains with nonfibrous proteoglycan-rich microdomain inclusions.
by Celia Henry Arnaud | January 11, 2016
—Building Tissue Layer By Layer “ACS Meeting News: DNA-programmed assembly allows researchers to construct a human mammary gland in the lab” Just as there is a relationship between the structure and function of molecules, scientists suspect there is a relationship between structure and function of tissues and cells. Probing the latter relationship requires the ability to assemble tissues with specific structures. Zev J. Gartner and coworkers at the University of California, San Francisco, do this by attaching single-stranded DNA to cells and using DNA hybridization to direct tissue assembly. They pattern a surface with DNA sequences to which cells with complementary sequences adhere via DNA hybridization. They wash away excess cells and repeat the process with other DNA-labeled cells, growing tissue layer by layer. They then cleave the tissue from the surface and transfer it to a three-dimensional cell culture matrix where it continues to grow. The team is using the method to grow components of human mammary glands, sourcing cells from discarded tissue from breast reduction surgeries. Eventually, the researchers hope to grow tissues that could provide a more physiologically relevant screening platform for drug assays and studying breast cancer, Gartner said. It’s not clear, however, how well the tissue growth process will scale up. /articles/92/i12/Building-Tissue-Layer-Layer.html 20140324 ACS Meeting News: DNA-programmed assembly allows researchers to construct a human mammary gland in the lab Concentrates 92 12 /magazine/92/09212.html Building Tissue Layer By Layer cells, tissue, DNA-programmed assembly con scitech Celia Henry Arnaud materials Building Tissue Layer By Layer Chemical & Engineering News Building Tissue Layer By Layer Building Tissue Layer By Layer
by Celia Henry Arnaud | March 24, 2014
—Optical Method Maps Brain Tumor Borders “Medicine: With handheld probe, surgeons in the operating room might one day see where cancerous tissue ends and normal tissue begins” When surgeons remove brain tumors, they spend a lot of time snipping out tiny pieces of tissue at the borders between the tumors and healthy tissue.
by Michael Torrice | June 18, 2015
—Sorting neurons from preserved brain tissue “New methods allow researchers to sort cells in chemically fixed, frozen brain tissue by using flow cytometry” Neuroscientists routinely store brain tissue samples in brain banks for future analysis. Being able to use cell-sorting techniques such as flow cytometry on this preserved tissue would allow researchers to study the effects of drugs, environmental factors, and diseases on specific brain cell types.
by Wudan Yan | April 03, 2017