—Hard-to-get fungal natural products found “Technique produces compounds made naturally by tough-to-culture fungi or poorly expressed genes” Fungi have long been a prolific source of natural products that become FDA-approved medicines for bacterial infections, immune disorders, high blood pressure, and other conditions. Over 5 million fungal species, each with as many as 80 natural product biosynthetic pathways, are estimated to exist. But scientists can only culture a small fraction of fungi in the lab, and fungi don’t express all their biosynthetic gene clusters actively. In the past, researchers have produced several fungal natural products by engineering them into readily cultured microorganisms like yeast.
by Stu Borman |
April 16, 2018