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Modern Drug Discovery


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Table of Contents

March/April 1999
Volume 2, Number 2


  Forged in St. Anthony's Fire: Drugs for migraine
Ergot, a potent neurotoxin and vasoconstrictor found in a fungus that grows on rye, was one of the first effective migraine medications and has been a springboard for further migraine drug development.
Carol Hart
  Restoring magic to the bullets
Jim Kling
Humanized monoclonal antibodies (MAbs) are succeeding as drugs where mouse MAbs failed. Fully humanized MAbs are in the development pipeline, and therapeutic bispecific MAbs are extending the versatility of nature's magic bullets.
  A conversation with Stelios Papadopoulos
Tom Hollon
A master biotech dealmaker talks about the difference between science and Wall Street, pharma mergers, the risks of biotechnology, job security, and what a scientist needs to raise venture capital.
  Listeria-based vaccines
Brian Wojcik
Listeria monocytogenes causes food poisoning that can be fatal. Nevertheless, the unveiling of its life inside infected cells has inspired scientists to develop Listeria as a vehicle for vaccination against infectious disease and cancer.


  In Brief
  • Whole-cell HTS for antibiotics
  • Drug delivery via killer bedsheets
  • Synthesizing the bug buster of last resort
  • Combining two cancer drugs into one
  • A blood-brain barrier transporter?
  • Reducing pediatric AIDS
  • NIH tosses its hat into the pharmacogenetics ring
How Lipitor stole Zocor's lunch
  • Acres of Skin: Human Experiments at Holmesberg Prison
  • The BioCareer Center
  New Products
  Pittcon Review
Instrument makers are dedicated to drug discovery
  Ad Index
Et Cetera