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FEATURES |
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Multiple modes of drug delivery
Mona Mort
New drug delivery technologies, because of their convenience, efficiency, and decreased side effects, will take their place among today's usual modes of drug delivery, such as taking several pills several times a day or, even more unappealing to some people, visiting an office to get an injection. The popularity of new drug delivery modes will not only be a matter of convenience and reduced anxiety, but in some cases, these technologies will be a more effective way-perhaps the only effective way-to deliver therapeutics.
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Nanoscalpels: Immunotherapy for cancer
Patrick A. Baeuerle and Evelyn Wolf
A primary tumor can usually be completely removed by surgery, but single tumor cells, called micrometastatic or seminal tumor cells, may have already spread throughout the body. These cells are being characterized so that antibody-based drugs can be developed. Such drugs function as "nanoscalpels", completing the surgeon's work by taking out the disseminated tumor cells invisible to the naked eye and to conventional diagnostics.
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Are lipid emulsions the drug delivery solution?
Lynn Collins-Gold, Norbert Feichtinger, and Torbjörn Wärnheim
To maximize the drug potential of all molecules, there has been a renewed effort to find formulation strategies for compounds inadequately soluble in water. Fat emulsions for clinical nutrition became the starting point for using emulsions as a delivery matrix for lipid-soluble drugs.
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Targeting gene regulators for cancer therapy
Jeffrey M. Besterman and A. Robert MacLeod
Changes in gene expression are fundamental to the development of cancer. Recent evidence suggests that control of a few critical cellular enzymes may cause the deregulation of hundreds or thousands of genes, as is the case in cancer. Inhibition of these enzymes may provide therapeutic benefits by producing synergistic anticancer effects when combined with cytotoxic chemotherapeutics or differentiating agents. |
DEPARTMENTS |
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Content in Context
Delivering the goods
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9 |
Feedback from our readers |
11 |
News in Brief
- Self-regenerating antibiotics
- Clearing up skin inflammation
- New genes restore "heart" to failing hearts
- Breast cancer and lymph nodes
- Intolerant mice provide clue to multiple sclerosis
- Unlocking the blood-brain barrier
- Hormonal therapy for treating breast cancer
- Like a bridge over troubled bloodstreams
- Making scents of pleasing aromas
- Finding leads fast and cheap by bioinformatics
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To Your Health
Sleep: Get it or regret it |
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Patents and Property
Cornerstone of an industry
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Money Matters: Corporate
Biostartups are fertile ground for entrepreneurs.
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The Tool Box
Superindex" developed to access legacy data
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71 |
The Time Line
Benjamin Rush and heroic medicine |
77 |
Sites and Software
Choosing a discovery framework |
81 |
Ready to Read
- Pills-A-Go-Go: A Fiendish Investigation into Pill Marketing, Art, History & Consumption
- Genomics: The Science and Technology Behind the Human Genome Project
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83 |
New Product Notes |
85 |
On the Calendar |
88 |
Diseases and Disorders
Tangled webs and sticky plaques |
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