FEATURES |
28 |
Building chirality from the ground up
Ray McCague
Researchers typically work with isomer mixtures to save time and resources, with the idea that the most appropriate isomer can be identified later during development-an approach that is particularly evident in combinatorial chemistry. This strategy forgoes any knowledge that might be gleaned from topological interactions between a potential drug entity and its target. There is a significant potential for competitive advantage in having ready access to multifunctional single-isomer "scaffolds"-chiral starting materials for combinatorial synthesis. |
36 |
Sorting out combinatorial chaos
Nicholas Sleep
As combinatorial chemistry increases the size of a company's main compound library, the complexity of managing these libraries increases as well. But for the library to remain useful to the R&D process, it needs to be accessible. Not only is it essential to manage the repository to physically locate and handle the compounds, but it is also vital to maintain detailed records of sample use and data from previous assays, while conserving stocks by restricting the use of scarce compounds. |
47 |
Chasing a cure for the common cold
Christie Aschwanden
Plenty of drugs targeting the body's response to cold viruses are already on the shelves-drugs such as antihistamines, nonsteroidal anti-inflammatories, and decongestants-but even better drugs may be on the horizon as scientists identify new inflammatory mediators involved in the body's reaction to colds. |
57 |
Early detection of cervical cancer
Robert J. Thomas
The need to identify cervical cancer in its early stages has driven researchers to focus on the underlying cause of the disease and how it can be detected at the molecular level. This research has produced overwhelming evidence that virtually all cases of cervical cancer are caused by the human papilloma virus (HPV), making it perhaps the first cancer to be recognized as virally induced. Enormous strides have been made in the HPV-cervical cancer area, which have produced an accurate and reliable molecular-based DNA test for the virus. This work should lead to effective therapeutics and eventually a vaccine against the disease |
DEPARTMENTS |
7 |
Content in Context |
9 |
From our Readers |
11 |
- News in Brief
- RNA virologists fell "The Big One"
- Breathing in the brain
- The cost of causing pain to animals
- Delivering the genes
- Suicide linked to 5-HT gene fault
- Vying for vision
- Breakthrough treatment for bone cancer patients
- Reducing pain with self-hypnosis
- ABO-incompatible kidney transplants
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25 |
To Your Health
Silence maims |
21 |
Insight and Analysis
Fraud in the German healthcare system
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25 |
Rules and Regulators
Policing Internet pharmacies |
67 |
Patents and Property
Of mice and men |
71 |
The Tool Box
Bubble jet biochip bonanza
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77 |
The Time Line
Defying diabetes: The discovery of insulin
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83 |
- Ready to Read
- Peptide Nucleic Acids:Protocols and Applications
- Conduct Unbecoming a Woman
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89 |
New Product Notes |
93 |
On the Calendar |
96 |
Diseases and Disorders
"I can't hear you" |
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