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Workstations. Gene Logic is now integrated with Staccato Applications-Focused workstations. The innovative liquid handling, stacking, and control software technologies provide a uniform architecture using reliable and economical building blocks. The technology, which can be used for multigene screening, generates high-quality gene expression data. It is cost-efficient and combines the instruments that are most often used in laboratory environments.
Zymark 150 Software. Scientific Data Management System (SDMS), a Web-enabled document-creation process, can be dynamically assembled into documents that reside in Documentum’s eContent Server. SDMS allows application-independent electronic capture, archival, and reuse of raw and report data generated from analytical instruments. Now linked with Document um, an industry standard system for electronic document management, SDMS gives scientists real-time access to assemble electronic submissions. Fraction collector. This instrument greatly expands the capabilities of the 1100 Series purification system. The modular flexibility of the system allows purification applications from analytical to large- scale preparative scale. The 1100 Series autosampler offers fast injection cycles for increased productivity and throughput. Analyzer. This ultrasensitive, ultraminiaturized, high-throughput instrument analyzes protein expression patterns in a single cancer cell. An atomic force microscope (AFM) is used for direct single-molecule detection to analyze solid-state arrays of proteins known to indicate cancer expression states in cells. These assays are configured as an array with 100 x 100 spots in a 0.1 x 0.1 mm area. Because of the high-resolution height detection of the AFM (0.5 nm), the binding of a sample protein is revealed by a change in the height of a specific spot on the array. No chemical, fluorescent, or radioactive labels are required. AFM scans are fully automated and take less than 1 h, allowing large numbers of cells to be rapidly screened with little human intervention.
Autosampler. This on-line unit allows automated introduction of nutrients in cell culture processing when preset limits are reached. The feedback control system consists of up to four remote power controllers, one distribution box, and cable connectors.
Online brochure. “Clinical Trials Insight” provides customers in the pharmaceutical and health care industries with advanced assessments of clinical trials. This product provides independent assessments of more than 20,000 published clinical trials annually, covering almost 30 therapeutic areas from more than 1700 biomedical journals and meetings. Customers can access key trial outcomes and their study messages, evaluations of clinical and commercial significance, competitive intelligence and trends, and clinical evidence to support brand positioning. Sieves. Whitehouse sieve standards sets provide a method of calibrating 8-in. (203-mm) diameter no. 6 (3.35 mm) and finer sieves with traceability to NIST. Sieves need not be taken out of service or sent to outside sources for calibration or verification until noncompliance is indicated by the user’s test results. Users can perform high-speed calibration in about 2 min/sieve in their own laboratories. Sets are presampled, single-use vials of highly spherical beads made from 2.45 specific gravity soda-lime glass. Chambers. Biocoat matrigel invasion units are a convenient, reproducible, and discriminating cell culture insert system for in vitro cell invasion studies.
BD Biosciences 159 Analyzer. This pH/gas instrument is designed specifically for cell culture. The BioProfile pHOx provides rapid, accurate measurement of pH, pO2, and pCO2 in the most appropriate ranges for cell culture process development. The analyzer also provides calculated values for total CO2 (TCO2), bicarbonate (HCO3), CO2 saturation, and air saturation. Microprobes. A wide range of flexible Teflon microprobes is available for water baths; spectrophotometer cuvettes; im plantation in brain, muscle tissue, and blood vessels; rectal implantation in neonatal mice; and other uses. These fast-reading microprobes are strong, flexible, and completely sealed. They can be autoclaved or sterilized by the use of gas (ETO) or Cidex. They are available with a sensor lead as small as 0.009 in. in diameter. Columns. The silica-based anion-exchange BioBasic AX has exceptional stability. It is made from PEI bonded to base-deactivated silica, which provides better column lifetimes than coated materials. The PEI bonded surface allows the column to be used for anion exchange or hydrophilic interaction chromatography, depending on the mobile phase pH and organic modifier content.
Media bags. These single-use, flexible containers are used for sterile fluid containment and processing in pharmaceutical, biotechnology, and diagnostic applications. B3 Media bags are lightweight and sterile, virtually eliminating the cleaning, storage, and sterilization costs associated with reusable containers. This product is ideal for storage and processing of tissue culture media, harvest collection, buffer solutions, and other sterile fluids. Microtiter plates. The 96-well IMBP plates are used for detecting and isolating heteroduplex DNA fragments. Unlike gel-based mutation detection methods, IMBP binds strongly to mismatches that closely resemble base pairs. Assays are run on standard equipment, use no radiation or gels, and are completed in less than 1 h. Microarrayer. The high-performance benchtop OmniGrid Accent prints from three microtiter plates onto a 50-slide-capacity platform, and it supports a print head that holds up to 48 pins. The instrument produces high-quality arrays by printing with high accuracy and precision; center-to-center spot distances are adjustable in 2.5-µm increments. The space-saving benchtop arrayer also prints more than 4000 features per slide in 1 h at full pin and slide capacities. Handling system. This unit allows contaminant-free bag disposal and can be adapted to any reactor filling port. Filling the reactor takes place in a closed system, so staff members are fully protected against dust. Optical microscopy. The Montage Explorer optical microscopy system has a high-precision XYZ stepper stage that is automated in all three planes and offers up to 89 million pixels. The autocalibration function measures the alignment between camera and sample to ensure perfect stitching together of images. HPLC. The Breeze System is an all-in-one HPLC system consisting of a binary or isocratic pump, automated or manual injector, UV or refractive index detector, and Breeze software. The system was created for scientists working in laboratories not under government-mandated regulatory compliance. Web-based software. The Sombrilla system allows multiple users to access analysis results and data-handling software through a secure Web interface. The WebConnector ensures laboratory interconnectivity by providing data-viewing cap-abilities in a protected Internet data repository, which allows users to obtain information from any manufacturer’s instruments in any location. WebEnabler expands the system’s power and allows users to access instrument data-handling functionality and monitor systems remotely. Filter apparatus. Spartan is a ready-to-use holder for aqueous and organic HPLC samples that offers protection for columns and valves. Designed for HPLC samples, this filter is made of a low-binding regenerated cellulose membrane (0.2 or 0.45 µm) in a polypropylene housing. To accommodate different sample volumes, the Spartan is availiable in two diameters: 13 and 30 mm. Sample preparation. The Montage Generation kits provide all necessary reagents and disposable materials needed to clean up DNApreps and provide high-quality DNA suitable for the most sensitive genetic research applications. Using simple protocols, the kits eliminate lengthy bind-and-elute methods and time-consuming centrifugation steps. Following the protocol allows users to collect purified samples from the top of the 96-well plate. Catalog. “Best CELLers” provides information on many cells, including all standard, fluorescence, and special-application types. Also included in the catalog are secondary calibration standards, quartz microplates, fiber-optic immersion probes, and cell cleaning solutions. Brochure. “Providing the Tools for Discovery” presents detailed information on the company’s line of filtration, separation, and detection products for molecular biology and drug discovery. New and long-time products are available to life scientists for applications at every step of the research process, including sample preparation, sample purification, PCR/labeling/probe prep, transfer and detection, and high-throughput technologies. Also available are membranes and kits for transfer and immobilization, rapid molecular separation devices, and 96-well filter plates.
HPLC. The LC-2010 series are fully integrated and include the system controller, membrane degasser, pumps, quaternary gradient formation unit, high-speed autosampler, column oven, and a 190–600-m UV detector with a temperature-controlled flow cell. Sample injections can be made in 15 s, and injection accuracy is maintained as demonstrated by the ability to consistently give precision of <0.3% RSD. Sample capacity is provided for vials of 350 x 1 mL, 210 x 1.5 mL, and 100 x 4 mL, and four standard or deep-well titer plates. Titrator. The MicroLab 500 is a precise way to vary the solution conditions of samples during light-scattering experiments. The dual-syringe feature of this titrator supports two standard sample-handling modes: an external mixing mode that supports a flow cell for larger volumes and dilutions, and an internal mixing mode for smaller volumes and kinetic experiments. When coupled with Dynamix software, this instrument automates solution condition variation. Software. ArrayStat provides comprehensive statistical analysis of gene expressions array data. This software answers microarray and macroarray data analysis questions such as which expressions changes are statistically significant and which spots are poorly reproduced. In addition, the program analyzes data from a variety of array data file formats, providing reliable analysis with as few as two replicates per spot. Interface. CrossFire Web is an advanced desktop client for the CrossFire Beilstein and CrossFire Gmelin databases, providing CrossFire Direct users with more efficient and comprehensive database searching and evaluation of results. Features include easy data search function for data queries, a reporting function that collects and presents all types of data, and the ability to hyperlink into CrossFire Web from a second application. Mass spectrometer. The Radiance Pro is a photoionization instrument for high-speed, high-throughput analysis of compound libraries and sample arrays for drug discovery. Offering a combination of accurate and high-speed analysis, Radiance Pro’s compound screening technology helps eliminate molecular analysis bottlenecks. It also speeds the serial drug development process by performing early screening for preclinical properties. Fluid controller. The NanoFlow fluid module allows nanoliter control of fluid in an experimental chamber or cell for biological and chemical experiments on a nanoscale level. Computer control lets the user switch between five different fluids or to adjust salt and molecular concentrations, pH, and more without interrupting or disturbing imaging. Nano Flow is compatible with closed and open fluid cells. Database. LifeSeq assembles more than 4 million proprietary and public-domain sequences taken from more than 1000 different cDNA libraries. Lifeseq allows users to search, at no cost, for a human gene of interest in the database. Once the gene is discovered, the following options—best gene view, most 5´ EST sequence, full-length clone, and most 5´ EST clone—are available. For more information, the appropriate numbers may be used on the Electronic Readers Service |
Syringe pumps. The MicroPro series provides pulseless, microliter-per-minute flow rates for chromatography and LC/MS. Ternary and quaternary gradient flow rates are as low as 1.0 µL/min. Users program the pumps for a variety of operation modes by using menu-driven screens on an easy-to-read display. Modes of operation include isocratic HPLC, binary-to-quaternary gradients, reciprocating syringes, and multiple independent syringes. Pump options include syringe temperature control, various types of valves, and a micromixing chamber.
Floor stand. The S7 unit is used with ophthalmic surgical microscopes. It is compact, modern, and conceals an interior filled with state-of-the-art technology. The long arm provides a work range that practically eliminates the need to reposition the stand. When repositioning is needed, however, the S7 floor stand is moved with ease. Four flexible casters guarantee easy maneuverability.
