Modern Drug Discovery ACS Publications
September 2002 From Concept to Development
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Volume 5, Issue 9
Article Indexes
Author Indexes



Surveying the binding site (540 KB)
by Randall C. Willis
If you want to use a protein´s structure for virtual drug screening, what do you do if you don´t know which of its many cracks and crevices might be important to its function? Basically, how do you find its ligand-binding sites? Researchers are using a variety of sequence alignment and molecular modeling tools to assist them in docking virtual molecules into real or model proteins.

The microfluidic milieu (279 KB)
by Mark S. Lesney
The coming microfluidic wave involves microlaboratories, or µTAS (micro total analysis systems). Miniaturized instruments on microchips can perform the gamut of standard analytical and synthetic processes. The ultimate goals are to capture new drug candidates for clinical trial and to lock down potential drug targets. Fabricating these microlabs is an art form in itself, relying primarily on the same etching and molding technologies used to produce computer microchips.

The microfluidic milieu


Content in Context
Cost ineffective (42 KB)
by James F. Ryan

News in Brief
TB costs: On the second line
Discovery puzzle
Electro-chemical "SNP-its"
No silken shrouds?
Eyeing uninhibited nerve regeneration
Examining the sweet tooth
Cancer-killer tomatoes
Amoeba motion may be key for cancer

For Your Health
Concerns dim vaccines´ luster
(134 KB)
by Julie L. McDowell
Despite the benefits of inoculations against life-threatening diseases, some parents and pediatricians worry about dangerous side effects.

New Product Notes (105 KB)


Rules and Regulators
Managing the pharma freebies (143 KB)
by Charles Schmidt
As hospitals and clinics restrict drug samples, the industry is moving to vouchers, coupons, and dispensing machines to attract new prescriptions.

The Tool Box
How to picture a protein
(132 KB)
by Nancy K. McGuire
Tracking site-specific cell functions is a lot easier with a transmission electron micrograph of the site.

Sites and Software
Bioinformatics: embracing genetic ontology
(156 KB)
by Mark S. Lesney
The problem of biological information lies not just in untidy databases but in the language of research.

On the Calendar
AAPS Annual Meeting and Exposition (53 KB)

Diseases and Disorder
Bell´s palsy
(96 KB)
by Felicia M. Willis


ISSN 1532-4486