Next stop, glycomics (245 KB)
by Mark S. Lesney
Some researchers speculate that the manipulation of sugars has led to the complexity possible in multicellular life forms. In this vein, posttranslational glycoprocessing may even account for part of the versatility of what appears to be a surprisingly low number of genes in the human genome. Appropriate sugar attachment and processing appear critical to correct protein folding as well as to the ultimate localization of proteins.

Content in Context
The cutting edge (43 KB)
by James F. Ryan

News in Brief (132 KB)
• Drugs from toxins
• Babes and blood pressure
• Photoswitchable proteins
• Bacterial stroke strain
• Microfluidics and MALDI-TOF
• Eye contact that delivers
• Honey! I lowered my cholesterol
• Arthritis: Monoclonal medicine

Clinical Trials Track
The assent of children (113 KB)
by Mark S. Lesney
Pediatric trials promise benefits to juveniles and big bucks to Big Pharma.

Sites and Software
Piecing together MS data (110 KB)
by Randall C. Willis
Researchers are using a variety of data analysis programs to identify proteins from their mass spectra.

Patents and Property
Pursuing overseas patents (81 KB)
by James E. Ruland
Avoid missing the boat with respect to absolute novelty and expenses.

The Tool Box
In situ proteomics (159 KB)
by Michelle L. Reyzer and Richard M. Caprioli
Researchers are applying MS directly to tissue sections to determine the localized expression patterns of molecules.

The Time Line
A lifetime quest for a cure (86 KB)
by Julie L. McDowell
Driven by the death of loved ones and a commitment to science, Gertrude Elion helped launch a new wave in medicine.

Ready to Read
The Noonday Demon: An Atlas of Depression • The Best American Science Writing 2001 (97 KB)
Reviewed by Julie L. McDowell

New Product Notes (121 KB)

On the Calendar
ACS ProSpectives: Proteomics (82 KB)

Diseases and Disorders
Guillain–Barré syndrome (107 KB)
by Wilder D. Smith