Modern Drug Discovery ACS Publications
October 2002 From Concept to Development
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Volume 5, Issue 10
Article Indexes
Author Indexes



Cutting-edge crystallography (245 KB)
by David Bradley
The demand for protein crystallography in drug discovery is driven by the need to understand exactly how small-molecule drug candidates bind to their protein targets. Now, as we navigate the postgenomic world, there is a growing need for atom-by-atom snapshots of these targets. This is the realm of structural genomics, and high-throughput X-ray crystallography could be the key.

Next stop, glycomics (245 KB)
by Mark S. Lesney
Some researchers speculate that the manipulation of sugars has led to the complexity possible in multicellular life forms. In this vein, posttranslational glycoprocessing may even account for part of the versatility of what appears to be a surprisingly low number of genes in the human genome. Appropriate sugar attachment and processing appear critical to correct protein folding as well as to the ultimate localization of proteins.


Content in Context
The cutting edge (43 KB)
by James F. Ryan

News in Brief (132 KB)
Drugs from toxins
Babes and blood pressure
Photoswitchable proteins
Bacterial stroke strain
Microfluidics and MALDI-TOF
Eye contact that delivers
Honey! I lowered my cholesterol
Arthritis: Monoclonal medicine

Clinical Trials Track
The assent of children
(113 KB)
by Mark S. Lesney
Pediatric trials promise benefits to juveniles and big bucks to Big Pharma.

Sites and Software
Piecing together MS data
(110 KB)
by Randall C. Willis
Researchers are using a variety of data analysis programs to identify proteins from their mass spectra.

Patents and Property
Pursuing overseas patents
(81 KB)
by James E. Ruland
Avoid missing the boat with respect to absolute novelty and expenses.


The Tool Box
In situ proteomics
(159 KB)
by Michelle L. Reyzer and Richard M. Caprioli
Researchers are applying MS directly to tissue sections to determine the localized expression patterns of molecules.

The Time Line
A lifetime quest for a cure
(86 KB)
by Julie L. McDowell
Driven by the death of loved ones and a commitment to science, Gertrude Elion helped launch a new wave in medicine.

Ready to Read
The Noonday Demon: An Atlas of Depression
The Best American Science Writing 2001 (97 KB)
Reviewed by Julie L. McDowell

New Product Notes (121 KB)

On the Calendar
ACS ProSpectives: Proteomics
(82 KB)

Diseases and Disorders
Guillain–Barré syndrome
(107 KB)
by Wilder D. Smith


ISSN 1532-4486