Modern Drug Discovery ACS Publications
January 2003 From Concept to Development
MDD home
Volume 6, Issue 1
Article Indexes
Author Indexes



Monitoring microbes (305 KB)
by Randall C. Willis
Methods such as the enzyme-linked immunosorbent assay rely on the specific interaction of antibodies directed against microbial surface antigens. Such assays can identify microbial isolates, but their effectiveness is often compromised because many microbes have found ways of altering their surface antigenicity. New methods have been developed that identify microbes by a relatively unchanging factor: their genetic material. For example, Canadian researchers recently developed an assay to distinguish between two Candida species in blood samples. This is especially important because C. albicans and C. dubliniensis require entirely different patient treatment regimens.

Monitoring microbes

Gene therapy: Hope in a cautionary tale (141 KB)
by Mark S. Lesney
In the early 1990s, gene therapy changed from science fantasy to viable technique with the work of cancer researcher W. French Anderson. Since then, it has proved a cautionary tale of the rocky and frustrating road toward success. Gene therapy, especially when combined with traditional chemotherapy, has shown itself capable of causing lethal tumors to vanish. But there have been nightmare chapters as well. In clinical trials, gene therapy has killed one youth and caused cancer in a three-year-old boy. Although directed targeting does not eliminate insertional mutagenesis or oncogenesis, it has the potential to limit the number of statistical chances for such a problem to occur.

Gene therapy: Hope in a cautionary tale


Content in Context
Dick and Gene?
(33 KB)
by James F. Ryan

News in Brief (75 KB)
Single-cell genotypingCotton: The fabric of our librariesContracts don’t cut it?Affecting a jaundiced view?Building bonesSignaling cell death

The Business Page
The Executive Interview
(62 KB)
Bill Linton, Promega Corp.: “I have vivid memories of watching Dad work on engines.”
Interviewed by James Ryan and Christen Brownlee


The Tool Box
Membrane-based drug assays
(76 KB)
by Jeff Ruell
Permeability assays and oral absorption modeling can make the difference between drugs and dregs.

New Product Notes (107 KB)

On the Calendar (50 KB)
LabAutomation in the desert: Palm Springs is the place

Diseases and Disorders
(61 KB)
by Christen Brownlee