Modern Drug Discovery ACS Publications
February 2003 From Concept to Development
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Volume 6, Issue 2
Article Indexes
Author Indexes



Scanning the code for combichem (268 KB)
Kevin Braeckmans, Stefaan C. De Smedt, Marc Leblans, Chris Roelant, Rudi Pauwels, and Joseph Demeester
“Multiplex” technologies, which enable researchers to carry out millions of synthetic reactions and biological tests in parallel on a miniature scale, are useful in fields such as clinical and genetic analyses and diagnostics. One approach to multiplexing is bead-based fiber-optic arrays, which use microspheres encoded with fluorescent dyes. When excitation light is sent through the fibers, the emerging fluorescence of the beads is captured by the same fibers and sent to a charge-coupled device camera with optical filters to obtain an image of the microwell array. Each bead is subsequently identified through its optical signature.

Scanning the code for combichem

The virtual patient (148 KB)
by Randall C. Willis
Researchers have developed “biomedical Pinocchios” on whom compounds can be tested. Using these computational puppets, or virtual people, scientists hope to fine-tune real-world assays and, ideally, eliminate dead-end leads from trials before they are even synthesized. To that end, model systems have been developed that mimic the various healthy and diseased states against which the drug candidate is to be tested.

The virtual patient


Content in Context
(29 KB)
by James F. Ryan

From Our Readers (49 KB)
Knocking nutraceuticalsMis-affiliationOh me, oh myElion error

News in Brief (109 KB)
Beneficial teaSense and markabilityBack pain, all in the brainADHD and autism: Chromosomal connection?Mass and metabolitesCancer immunotherapyMice glowMatching genes and substructures

Developing diureticsThe Time Line
Developing diuretics
(67 KB)
by Richard A. Pizzi
From mercurials to the thiazides, these “urine promoters” have proved to be some of the most prescribed therapeutics.


HapMapping the genomeApplications NoteBook
HapMapping the genome
(77 KB)
by David Bradley
International teams of researchers are correlating SNPs with gene locations.

The Business Page
Patents and Property
(58 KB)
by David Filmore
Diverse opportunities for patent protection help drive combichem technology.

The Tool Box
A work in process
(73 KB)
by Tim N. Warner and Sam Nochumson
Membrane-based chromatography is paving the way for high-throughput biopharmaceutical processing.

New Product Notes (59 KB)

Diseases and Disorders
(93 KB)
by Erik Whitemon