Modern Drug Discovery ACS Publications
June 2003 From Concept to Development
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Volume 6, Issue 6
Article Indexes
Author Indexes



A knockouts tail (199 KB)
by Mark S. Lesney
Knockout technology—deliberately disabling a particular gene—is being applied to mice, zebra fish, and, most recently, human embryonic stem cells. Protein modeling can often provide information on function, especially if the homologous protein is well known. But for unknown proteins, or for genes with multiple effects, determining what a gene does in an organism requires tampering with its operation in a test animal.

A knockouts tail
Playing the protein polyphony (345 KB)
by Mark S. Lesney
Analyzing the structure and function of proteins can be likened to the analysis of a complex piece of music rather than a simple detailing of chemical bonds. For researchers to listen to these cellular symphonies, they must be played on a variety of instruments—not mandolins and harpsichords, but on MS and NMR.

Playing the protein polyphony

Chirality in a combinatorial age (245 KB)
by David Filmore
Convincing differential effects from enantiomer-specific pharmacological interactions have led to a rising prevalence of enantioselective drug design. Seventy-six percent of the new drugs introduced in 2000 were single enantiomers, compared with 21% in 1991. The expectation for enantiomeric purity in new chiral drugs is escalating, causing an increased reliance on the challenging analytical task of quantifying enantiomeric content.

Chirality in a combinatorial age


Content in Context
Maps and models
(28 KB)
by James F. Ryan

From our Readers (46 KB)
Weighty mattersMicrofilarial musings

News in Brief (182 KB)
Fusion inhibitor approvedPumping ironThe shorter the betterLoofa liversAftificial glycoviral vectorsPenetrating the skin you’re inSample prep schoolParticle size on the flyImaging with monoclonalsChanging peptide partners

'Magic' monoclonalsThe Time Line
“Magic” monoclonals
(80 KB)
by Richard A. Pizzi
Only in the era of Herceptin have antibodies begun to fulfill Ehrlich’s dream of “magic bullets” from blood serum.

Applications NoteBook
A matter of size
(99 KB)
by Randall C. Willis
Researchers are finding new ways to use field-flow fractionation for sizing everything from polymers to human cells.


The Business Page
Matters of money
(53 KB)
By Neil Canavan
In a down market, biotech can bank with the nonprofits.

The Tool Box
A measured solution
(77 KB)
by Jeffrey Ruell and Alex Avdeef
Researchers are using different techniques to address drug solubility issues.

Pharma down PATRules and Regulators
Pharma down PAT
(102 KB)
by Charles W. Schmidt
An FDA initiative promoting continuous monitoring of the drug manufacturing pipeline appears to be gaining momentum.

On the Calendar (387 KB)
DDT 2003

Product Info Now (212 KB)

Diseases and Disorders
Chronic hiccups
(47 KB)
by Felicia M. Willis