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January 2004 Table of Contents

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January 2004

CD microlaboratoryFeatured Product: CD microlibrary
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Gyrolab Bioaffy allows scientists to run established sandwich-based immunoassays for protein quantification at a nanoliter scale. This CD microlaboratory, together with an updated Gyrolab Workstation with laser-induced fluorescence detection, can assay proteins in a format optimized for working with small volumes and many samples. Nanoliter-scale procedures offer a major reduction in sample and reagent consumption per data point. Time-consuming and costly investigations caused by limited availability of sample, such as biomarker profiling in small-animal models, can be reduced to days rather than weeks with more proteins being assayed in a single sample.

“Gyrolab Bioaffy and our sample preparation CD, Gyrolab MALDI, are both run on Gyrolab Workstation, demonstrating the flexibility of the Gyros technology platform,” said Per Sjöberg, executive vice president of marketing and sales at Gyros AB. “Users can benefit from a single instrument that runs different application CDs as required. Our development strategy is to focus on areas in which miniaturization and integration of protein applications into a CD microlaboratory have clear advantages. Gyrolab Bioaffy will allow the customer to assay their proteins in a format optimized for working with small volumes and many samples.”

Sjöberg added that demonstrations and customer collaborations can be performed at Gyros facilities in Princeton, NJ, and Uppsala, Sweden. Anyone with a serious interest is encouraged to contact Gyros representatives to arrange a visit.

Gyros AB - www.gyros.com


Rack organizerRack organizer. The Bambino is a benchtop component mounting system that accommodates several animal handling devices. A convenient organizer system, the versatile rack was designed to hold components for automated blood sampling, microdialysis, ultrafiltration, in vivo biosensors, behavior monitoring, and metabolism studies. Each Bambino benchtop unit can house a single animal. The following options can be selected to outfit the Bambino system: automated blood sampling, interactive caging, infusion, a microdialysis bowl kit, and metabolic caging.
Bioanalytical Systems - www.bioanalytical.com

Transfer station. The AniGARD VF is a spacious animal transfer unit that accommodates a variety of cage sizes and offers operators a wide work area. The VF is a larger version of the AniGARD II. The VF is a vertical-flow, recirculating-air clean bench designed to provide animal protection and particulate control during routine cage-changing operations while maximizing productivity and flexibility.
Baker Company - www.bakerco.com

Tubes. ScrewTop TrakMates provide 2D bar-coded storage solutions with the release of the tube. The system features an 8 X 12 format screw tube and rack, and it has a globally unique 2D bar code permanently attached to each screw-top tube. Good for temperatures down to –178 °C, each tube can now be linked to a database containing each tube’s contents for secure sample tracking.
Matrix Technologies - www.matrixtechcorp.com
LabAutomation Booth No. 1506

Syringe filtersSyringe filters. The Millex line is a series of automation-compatible syringe filters that eliminate filter-related problems that can shut down automated systems. Unattended operation of workstations is possible in applications such as dissolution testing and HPLC sample preparation. Millex filters have a smooth, domed housing instead of the sharp edges on conventional syringe filters. They operate on a variety of automated systems and are available with nylon membrane, polyvinylidene fluoride (PVDF) membrane, polytetrafluoroethylene (PTFE) membrane, mixed esters of cellulose membrane, and glass fiber filters in packs of 200 and 1000.
Millipore - www.millipore.com
LabAutomation Booth No. 907

Mass spectrometer. The GV2003 CO2 and N2 instrument is a safe, rapid, and noninvasive breath-testing tool for a number of clinical conditions, such as Helicobacter pylori infection, fat malabsorption, gastric emptying, lactose intolerance, amino acid oxidation, liver function, fatty acid oxidation, intestinal overgrowth, and metabolic turnover. The GV2003 uses a versatile gas preparation module to meet these demands. This enables precise and accurate determination of both 13C and 18O in CO2. The GV2003 uses an online internally calibrated CO2 reference gas which is measured immediately after each breath CO2 sample. The use of online calibrated CO2 gas, rather than external gas standards in sample containers, eliminates potential gas-handling errors and ensures that the maximum number of autosampler positions are filled with either breath or QA/QC samples.
GV Instruments - www.gvinstruments.co.uk

Packaging systemPackaging system. The Retro-X provides a fast method for producing high titers of replication-incompetent retrovirus with the host range required for experiments. The packaging system can be used with any Moloney murine leukemia virus (MMLV)-based expression vector and is ideal when testing multiple expression constructs because recombinant retrovirus can be obtained in only 48 h. The Retro-X includes the GP2-293 cell line, which has the MMLV gag and pol genes stably integrated in its genome. It also includes four different envelop vectors for targeting any host cell. Stable expression of the viral Gag and Pol proteins from the GP2-293 genome contributes to high viral titers and eliminates overexpression.
BD Biosciences - www.bdbiosciences.com
LabAutomation Booth No. 1319

Catalog. The 2004 edition of Cayman’s catalog contains hundreds of new biochemicals, including eicosanoids, nitric oxide reagents, lipids, fatty acids, inhibitors, antibodies, and enzymes. It features new HTS fluorescence assays and a broad line of sensitive EIAs in metabolism, oxidative stress, and inflammation. This edition contains technical charts, illustrations, and gene maps that can be used as reference tools or adapted to teaching presentations.
Cayman Chemical - www.caymanchemical.com

DetectorDetector. The Optilab rEX refractometer with EXtended range is an RI detector that offers chromatographers 256 times the detection power and up to 50 times the dynamic range of other RI detectors. It incorporates cutting-edge semiconductor photodiode technology and proprietary computer algorithms. The Optilab rEX flow cell comes standard with a total volume of only 7.4 µL, 25% less than other refractometers available today. This reduced volume minimizes band broadening and improves temperature stability. The Optilab rEX also can measure the absolute refractive index of a solution online. It is compatible with all HPLC systems and is ideal for many applications, including polymers, biopolymers, proteins, fatty acids, triglycerides, carbohydrates, and starches.
Wyatt Technology - www.wyatt.com

Palladium catalyst. PS-PPh3-Pd is a polymer-bound resin catalyst for Suzuki-Miyaura coupling reactions between aryl boronic acids and aryl halides. The resin was developed to simplify the removal of residual palladium during workup and product isolation for active pharmaceutical ingredients. PS-PPh3-Pd resin offers a broad scope of reactivity and the added convenience of a polymer-supported reagent for handling and purification.
Argonaut Technologies - www.argotech.com

Postsynthesis station. The Carousel Work-Up is a compact and lightweight station that accepts up to 12 X 70-mL columns for filtration, phase separation, liquid/liquid extraction, or SPE into one or two identical stackable racks. This enables parallel and/or sequential workup of 12 samples and collection of product into a lower rack with Carousel Reaction Tubes or standard 1-in. boiling tubes. The design uses no taps, valves, or drip needles, and the system can be used under gravity or with the SpeedFlow Booster, allowing precise individual control of flow in each column. The Carousel Work-Up station uses lightweight aluminum racks.
Radleys Discovery Technologies - www.radleys.co.uk

LC flowmeters. These units are made for measurements below 50 µL/min and offer resolution down to 0.5 nL/min. They are fully digital, calibrated meters with a repeatability of 0.8% and a readout speed of 200 readings/s. Applications include system validation, column flow monitoring, leak detection, and pump pulsation checks.
Sensirion Ag - www.sensirion.com

Media transfer system. The QFresh is designed to exchange cell culture media in Petri dishes. It takes 10 min to process a stack of 20 dishes, aspirating “old” media and replacing it with fresh media. The compact design allows the unit to be used in a laminar flow cabinet for complete sterile operation. It is ideal for tissue culture applications involving adherent mammalian cells or solid-support culture of plant cells and is compatible with standard-depth 10-cm Petri dishes and tissue culture dishes.
Genetix Ltd. - www.genetix.com
LabAutomation Booth No. 425

Plate sealer. The TriSeal is an automated unit that produces an accurate and tight seal on any SBS-proposed standard plate from 15 to 45 mm in height. Incorporating a turntable design, which allows simultaneous loading, unloading, and sealing, the TriSeal achieves an average rate of 12 plates/min. Offering adjustable sealing temperatures from 50 to 185 °C, the TriSeal works with most foil and film seals. A swing-out loading shoe feed design allows fast and easy loading of foil or films.
Porvair Sciences - www.porvair-sciences.com
LabAutomation Booth No. 1518

Vial labelsVial labels. Freezer Bondz is a thermal transfer printable label material capable of adhering to frozen surfaces. These labels can be applied to cryogenically frozen vials and will stay in place over time. Freezer Bondz will survive exposure to common laboratory environments such as liquid nitrogen, freezers (–70 °C), autoclaves, and 100 °C hot-water baths. It is also resistant to chemicals including ethanol, DMSO, and xylene.
Brady Corp. - www.bradylabid.com

Discovery software. Knowledge Discovery Environment 1.9 is an enhanced Open Discovery Workflow solution designed to create, capture, and manage valuable process knowledge in the high-throughput discovery environment. Open Discovery Workflow technology enables researchers to build reusable workflows that integrate, mine, analyze, and visualize information. It supports innovative discovery research and captures research creativity as process knowledge. Discovery productivity is enhanced by the execution of advanced, integrated, biological and chemical analyses, which incorporate all the required data sources, applications, and algorithms.
InforSense - www.inforsense.com

Antibodies. These mouse monoclonal IgGs were raised against PtdIns(3,4)P2, PtdIns(3,5)P2, and PtdIns(3,4,5)P3. They are available for 5 of the 7 naturally occurring phosphoinositides. An anti-phosphatidylinositol antibody is currently in development. All of the anti-PIP antibodies primarily recognize the head group of their cognate phosphoinositide, and they show low cross-reactivity with other phosphoinositides or phospholipids depending on the assay format.
Echelon Biosciences - www.echelon-inc.com

Microscope objectives. The XLFluor4x/340 and XLFluor2x/340 water immersion objectives are optimized for GFP observation, zebrafish studies, and in vivo experimentation, along with other advanced fluorescence microscopy applications. The two objectives deliver transmission from 330 to 700 nm and have high numerical apertures (NAs) for unprecedented light-gathering capability. The XLFluor 2x/340 has an NA of 0.14 and a working distance of 16.3mm. The XLFluor4x/340 has an NA of 0.28 and a working distance of 29.5mm.
Olympus - www.olympus.com

Kits. DirectPrep 96 Miniprep sets are designed for cost-effective, manual, or fully automated high-throughput DNA purification from high-copy plasmids. The system uses a simple one-plate procedure and a new lysis step that makes clearing of the lysate unnecessary. The purified DNA is suitable for use in standard, high-throughput downstream applications. Yields of up to 4 µg of high-copy plasmid DNA are typically obtained from 1.25 mL of E. coli culture grown in LB medium. Furthermore, the yield of plasmid DNA is sufficient for several sequencing reactions and additional archiving of the sample.
Qiagen - www.qiagen.com

Catalog. The Molecular Biology Solutions Product Guide contains all of the recently launched molecular products, including the new PxE Thermal Cycler, the KingFisher 96 for high-throughput DNA purification, and siRNA oligonucleotides for gene function analysis. The introduction of this solutions-based product guide marks the integration of many Thermo businesses under the Bioscience Technologies Division of Thermo Electron. Containing a cross section of products from many of the different business units, including Thermo Hybaid, Thermo Labsystems, Thermo Savant, Thermo EC, and Thermo CRS, the guide presents the products with a specific molecular biology application.
Thermo Electron - www.thermo.com
LabAutomation Booth No. 507

Colorimeter. The Lovibond PFX195 product line includes instruments specialized for the analysis of liquid chemicals, industrial oils, petroleum oils, fuels, dark oils, fats, beers, malts, caramels, pharmaceutical solutions, industrial oils, surfactants, sugar solutions, syrups, honey, water, wastewater, and transparent liquids. The PFX195 series offers a choice of more than 20 color scales. Each version includes a selection of scales that are typically used depending on the industry sector, but additional scales can be added as optional upgrades. The instrument allows the user to obtain the closest match to stored references or to build up a customized scale from a series of reference samples.
Petrolab - www.petrolab.com

2D gel. The a2DE is the world’s first fully automated system for running high-resolution 2D electrophoresis. It runs the processes involved with 2D separation without user supervision or intervention, minimizing hands-on time, increasing reproducibility, simplifying the technique, and optimizing results. In addition, the a2DE automates gel casting to specified acrylamide gradients, significantly increasing reproducibility and enhancing protein resolution.
NextGen - www.nextgensciences.com

Spin columns. PepClean C-18 units concentrate peptide samples and remove common biological contaminants for mass spectrometric analysis. Each column contains a porous C-18 reverse-phase resin with recovery characteristics for a wide range of peptide concentrations. The spin-column format allows processing of multiple samples (10–150 µL) in 30 min.
Pierce Biotechnology - www.piercenet.com
LabAutomation Booth No. 1218

Electrode. The Syntrode line measures pH values in chemically demanding samples with a long-term thermal behavior that meets the requirements for continuous and reliable monitoring of syntheses. The electrodes are available in lengths of 30 or 45 cm and feature a fixed ground sleeve diaphragm.
Brinkmann - www.brinkmann.com
LabAutomation Booth No. 632

Refractometer. The Refracto 30GS is a portable, digital unit designed for laboratory and production environment measurements. It stores up to 1100 results, including sample identification, measurement unit, temperature compensation coefficient, date, and time. It features a sapphire measuring cell that has a higher refractive index and better thermal conductivity than glass for an extended measuring range.
Mettler-Toledo - www.mt.com
LabAutomation Booth No. 535

Detergents. The Focus line is specifically purified without the use of methylene chloride or other potential protein denaturants. These detergents are suitable for membrane and total protein extraction and 2D gel electrophoresis. They come packed in glass serum vials under inert gas to maintain quality.
Genotech - www.genotech.com

Brochure. The Volume 3, Number 5 edition of ChemFiles features the latest products for organic synthesis. The publication contains organometallic complexes and ligands, ionic liquids, halogenated aryl derivatives, aryl sulfonyl chlorides, bifunctionalized building blocks, alkoxysilanes, aromatic terminal alkynes, and solid-phase, polymer-bound reagents.
Sigma-Aldrich - www.sigma-aldrich.com

Image analyzerImage analyzer. GeneFlash integrates a benchtop darkroom with a digital camera, flash card technology, and color LCD screen. The unit can be coupled with GeneGnome HR, a high-resolution, chemiluminescent image analyzer, using chip technology, and with either the GeneGenius Super12 high-resolution gel documentation system or the ChemiGenius2 analyzer for fluorescent and chemiluminescent applications. The compact system with built-in transilluminator software provides instant image capture and analysis.
Syngene - www.syngene.com


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